Transvascular drug delivery in solid tumors

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Important Advances in Oncology

1991 • 768 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras

1981 • 681 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Transport of macromolecules across microvascular walls: the two-pore theory

1994 • 537 citations

Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2.

1986 • 534 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine

1997 • 474 citations

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1994 • 463 citations

Late effects of radiation therapy in the head and neck region

1995 • 457 citations

Neovasculature induced by vascular endothelial growth factor is fenestrated.

1997 • 441 citations

Liposomes Revisited

1995 • 418 citations

Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.

1994 • 393 citations

Quantitative angiogenesis assays: Progress and problems

1997 • 386 citations

Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain Tumors

1970 • 371 citations

Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.

1993 • 368 citations

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.

1996 • 280 citations

Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma.

1992 • 275 citations

Delivery of molecular and cellular medicine to solid tumors

1997 • 268 citations

Thermosensitive liposomes: Extravasation and release of contents in tumor microvascular networks

1996 • 268 citations

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

1996 • 266 citations

Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor.

1996 • 250 citations

VEGF induces NO-dependent hyperpermeability in coronary venules

1996 • 247 citations

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.

1996 • 235 citations

Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.

1997 • 214 citations

Tumor angiogenesis and interstitial hypertension.

1996 • 212 citations

Treatment of advanced solid tumors with immunotoxin LMB–1: An antibody linked to Pseudomonas exotoxin

1996 • 208 citations

Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice

1993 • 207 citations

Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery.

1961 • 206 citations

Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.

1992 • 191 citations

Plasma proteins modify the endothelial cell glycocalyx of frog mesenteric microvessels.

1992 • 191 citations

Regulation of Angiogenesis

1997 • 187 citations

The three-dimensional organization of tight junctions in a capillary endothelium revealed by serial-section electron microscopy

1984 • 185 citations

Important advances in oncology 1996

1997 • 184 citations

Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity

1996 • 179 citations

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

1993 • 174 citations

Vascular endothelial growth factor, a specific regulator of angiogenesis

1996 • 169 citations

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

1997 • 168 citations

Fluid and protein fluxes across small and large pores in the microvasculature. Application of two‐pore equations

1987 • 165 citations

Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma.

1995 • 163 citations

Drug Resistance in Oncology

1997 • 160 citations

Capillary ultrastructure in human metastatic brain tumors

1979 • 156 citations

Lipidic Vector Systems for Gene Transfer

1997 • 155 citations

Pathophysiology of the blood-brain barrier

1990 • 153 citations

Absence of contrast enhancement on CT brain scans of patients with supratentorial malignant gliomas

1988 • 153 citations

Tissue Perfusion Inhomogeneity During Early Tumor Growth in Rats<xref ref-type="fn" rid="fn2">2</xref>

1979 • 152 citations

Clinical Studies of Liposome-Encapsulated Doxorubicin

1994 • 145 citations

Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis

1995 • 145 citations

Endothelial gaps: time course of formation and closure in inflamed venules of rats

1997 • 145 citations

Brain Tumors: An Encyclopedic Approach

1996 • 143 citations

A Phase-I Study of an Anti-CD25 Ricin A-Chain Immunotoxin (RFT5-SMPT-dgA) in Patients With Refractory Hodgkin's Lymphoma

1997 • 142 citations

Tumor oxygenation: a matter of supply and demand.

1996 • 141 citations

Transendothelial transport of low density lipoprotein in association with cell mitosis in rat aorta.

1989 • 141 citations

Antibody-directed targeting of the vasculature of solid tumors

1995 • 124 citations

Preferential distribution of anionic sites on the basement membrane and the abluminal aspect of the endothelium in fenestrated capillaries.

1982 • 122 citations

Histogenesis and ultrastructure of pancreatic islet graft microvasculature. Evidence for graft revascularization by endothelial cells of host origin.

1995 • 120 citations

Tumor necrosis factor activities and cancer therapy — A perspective

1993 • 119 citations

Measurement of Material Extravasation in Microvascular Networks Using Fluorescence Video-Microscopy

1993 • 112 citations

In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer

1997 • 110 citations

Quantification and pharmacokinetics of blood-brain barrier disruption in humans

1996 • 108 citations

Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro

1997 • 107 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Inhibits Anchorage-Disruption-Induced Apoptosis in Microvessel Endothelial Cells by Inducing Scaffold Formation

1997 • 98 citations

Chemotherapy of brain tumors: physiological and pharmacokinetic considerations.

1986 • 97 citations

UPTAKE OF LIPOSOMES BY RAT AND MOUSE HEPATOCYTES AND KUPFFER CELLS

1983 • 94 citations

Role of dying endothelial cells in transendothelial macromolecular transport.

1990 • 93 citations

Isolated lung perfusion with tumor necrosis factor for pulmonary metastases

1996 • 92 citations

Vascular ultrastructure in human meningiomas and schwannomas

1973 • 82 citations

1995 Whitaker lecture: Delivery of molecules, particles, and cells to solid tumors

1996 • 81 citations

Measurement of capillary filtration coefficient in a solid tumor.

1991 • 80 citations

Single capillary permeability to proteins having similar size but different charge

1988 • 79 citations

Ultrastructure of capillary walls in human brain tumors

1989 • 77 citations

Pathophysiology of the blood-brain barrier

1996 • 75 citations

Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.

1993 • 75 citations

Cerebral lymphoma presenting as a nonenhancing lesion on computed tomographic/ magnetic resonance scan

1993 • 74 citations

Enhancement of monoclonal antibody uptake in human colon tumor xenografts following irradiation.

1990 • 74 citations

Endothelial Barrier Function

1989 • 70 citations

Effect of seven new vasoactive immunoconjugates on the enhancement of monoclonal antibody uptake in tumors

1994 • 69 citations

Perfusion of Single Tumor Microvessels: Application to Vascular Permeability Measurement

1996 • 66 citations

Differential blood-brain barrier permeabilities to [14C]sucrose and [3H]inulin after osmotic opening in the rat

1983 • 63 citations

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.

1991 • 62 citations

Isolated limb perfusion for malignant melanoma

1996 • 59 citations

Prevention of immunotoxin-mediated vascular leak syndrome in rats with retention of antitumor activity.

1994 • 58 citations

Pharmacological blood-brain barrier modification for selective drug delivery

1995 • 58 citations

Cellular and Intercellular Transport Pathways in Exchange Vessels

1992 • 51 citations

Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.

1997 • 47 citations

Regulation of angiogenesis

1997 • 46 citations

[IMMUNITY TO CANCER].

1964 • 46 citations

Cellular and secretory mechanisms related to delayed radiation-induced microvessel dysfunction in the spinal cord of rats

1996 • 43 citations

Tumor-secreted vascular permeability factor/vascular endothelial growth factor influences photosensitizer uptake.

1993 • 41 citations

Endothelial surface charge of intestinal mucosal capillaries and its modulation by dextran

1991 • 40 citations

Simultaneous Measurement of Liposome Extravasation and Content Release in Tumors

1997 • 39 citations

Tissue-Isolated Human Tumor Xenografts in Athymic Nude Mice

1994 • 38 citations

Disposition characteristics of macromolecules in the perfused tissue-isolated tumor preparation.

1992 • 36 citations

Phase I trial of dose-intense liposome-encapsulated doxorubicin in patients with advanced sarcoma.

1997 • 36 citations

Initial studies on the administration of C1-esterase inhibitor to patients with septic shock or with a vascular leak syndrome induced by interleukin-2 therapy.

1994 • 36 citations

Future directions in hyperthermia biology

1994 • 34 citations

Changes in transcapillary exchange induced by perfusion fixation with glutaraldehyde, followed by measurements of capillary filtration coefficient, diffusion capacity and albumin clearance

1985 • 34 citations

Biological rationale for hyperthermia in cancer treatment (II).

1994 • 30 citations

Pharmacokinetic considerations on monoclonal antibodies.

1989 • 27 citations

The Eugene M. Landis Award Lecture 1993 Regulation of Water and Solute Exchange in Microvessel Endothelium: Studies in Single Perfused Capillaries

1994 • 24 citations

Fibronectin inhibits the cytotoxic effect of ricin A chain on endothelial cells

1996 • 24 citations

Possible mechanism(s) for permeability recovery of venules during histamine application

1992 • 21 citations

Endothelial transport of anionized and cationized ferritin in the rabbit thoracic aorta and vasa vasorum.

1984 • 21 citations

Isolated perfusion of the kidney with tumor necrosis factor for localized renal-cell carcinoma

1996 • 20 citations

Gliomas of the brain

1984 • 19 citations

Dexamethasone Decreases the Delivery of Tumor-Specific Monoclonal Antibody to Both Intracerebral and Subcutaneous Tumor Xenografts

1993 • 17 citations

A codiffusing system as a novel model for capillary wall charge selecivity

1996 • 16 citations

Tumour vessel permeability and transcapillary exchange of large molecules of different size.

1977 • 10 citations

Serial nonenhancing magnetic resonance imaging scans of high grade glioblastoma multiforme.

1993 • 10 citations

Permeability characteristics of microvascular walls

1984 • 6 citations

Clinical and Preclinical Trials of Isolated Liver Perfusion for Advanced Liver Tumors: Primary Liver Tumors

1996 • 6 citations

Failure of histamine type mediators to enhance vascular permeability in experimental liver metastases.

1980 • 6 citations

Dexamethasone Decreases the Delivery of Tumor-Specific Monoclonal Antibody to Both Intracerebral and Subcutaneous Tumor Xenografts

1993 • 6 citations