Extended release of adenovirus from polymer microspheres: potential use in gene therapy for brain tumors

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1991 • 8,402 citations

Biodegradable Long-Circulating Polymeric Nanospheres

1994 • 2,832 citations

The Basic Science of Gene Therapy

1993 • 1,767 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Polymers for the sustained release of proteins and other macromolecules

1976 • 1,127 citations

Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres.

1991 • 843 citations

Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios

1977 • 705 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

Epidemiology of brain tumors

1985 • 492 citations

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

1994 • 483 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health

1993 • 420 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies

1991 • 370 citations

Controlled Release of Bioactive Materials

1980 • 308 citations

A Glucose-Controlled Insulin-Delivery System: Semisynthetic Insulin Bound to Lectin

1979 • 304 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

Water and hydrogels

1973 • 292 citations

Adenovirus gene transfer causes inflammation in the brain

1995 • 283 citations

Double-walled polymer microspheres for controlled drug release

1994 • 280 citations

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1995 • 244 citations

Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.

1991 • 216 citations

Survival in Glioblastoma

1980 • 215 citations

Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.

1994 • 208 citations

Biodegradable Microspheres: Vaccine Delivery System for Oral Immunization

1989 • 198 citations

Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line

1990 • 195 citations

The controlled parenteral delivery of polypeptides and proteins

1990 • 190 citations

Gene Transfer into Experimental Brain Tumors Mediated by Adenovirus, Herpes Simplex Virus, and Retrovirus Vectors

1994 • 159 citations

Experimental Tumor Therapy in Mice Using the Cyclophosphamide-Activating Cytochrome P450 2B1 Gene

1994 • 156 citations

Prolonged Controlled-Release of Nafarelin, a Luteinizing Hormone-Releasing Hormone Analogue, from Biodegradable Polymeric Implants: Influence of Composition and Molecular Weight of Polymer

1986 • 152 citations

Long-acting delivery systems for peptides: inhibition of rat prostate tumors by controlled release of [D-Trp6]luteinizing hormone-releasing hormone from injectable microcapsules.

1984 • 144 citations

Expression of Escherichia coli β-Galactosidase and Rat HPRT in the CNS of Macaca mulatta Following Adenoviral Mediated Gene Transfer

1994 • 144 citations

An experimental model of retrovirus gene therapy for malignant brain tumors

1993 • 143 citations

Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain

1994 • 140 citations

Epidemiologic Study of Primary Intracranial Neoplasms

1981 • 135 citations

Adenovirus‐mediated gene therapy of experimental gliomas

1994 • 133 citations

Long-Term Survival in Patients with Malignant Astrocytoma

1994 • 129 citations

Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors

1993 • 110 citations

Pulmonary Inflammation Induced by Incomplete or Inactivated Adenoviral Particles

1995 • 103 citations

Epidemiology of primary tumours of the brain and spinal cord: a regional survey in southern England.

1976 • 103 citations

[8] Poly(lactide-co-glycolide) microcapsules for controlled release of steroids

1985 • 100 citations

Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas

1995 • 89 citations

Tissue Response to Biodegradable Injectable Microcapsules

1987 • 76 citations

Immunomodifiers in Vaccines

1989 • 72 citations

Control of diabetes with polyacrylamide implants containing insulin

1972 • 71 citations

Sustained pharmacological activities in rats following single and repeated administration of once-a-month injectable microspheres of leuprolide acetate.

1991 • 69 citations

Increasing brain cancer rates in Canada.

1991 • 66 citations

Glycosylated Insulin Complexed to Concanavalin A: Biochemical Basis for a Closed-Loop Insulin Delivery System

1983 • 62 citations

Progestin Permeation through Polymer Membranes IV: Mechanism of Steroid Permeation and Functional Group Contributions to Diffusion through Hydrogel Films

1979 • 59 citations

Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.

1994 • 55 citations

Some epidemiologic aspects of neoplastic diseases in Israeli immigrant population. III. Brain tumors

1968 • 43 citations

An adenovirus vector system used to express polyoma virus tumor antigens.

1985 • 42 citations

The Morbidity and Mortality of Brain Tumors: A Perspective on Recent Advances in Therapy

1985 • 38 citations

Adenovirus-Mediated Gene Therapy for Head and Neck Squamous Cell Carcinomas

1996 • 35 citations

Biodegradable poly(dl-lactide-co-glycolide) microspheres

1992 • 33 citations

Expression of human interleukin-1 receptor antagonist in mouse lungs using a recombinant adenovirus: effects on vector-induced inflammation.

1995 • 30 citations

Hydrolytic Degradation of Poly DL-(Lactide)

1981 • 25 citations

Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy.

1995 • 25 citations

POLYMERS FOR THE SUSTAINED RELEASE OF MACROMOLECULES: APPLICATIONS AND CONTROL OF RELEASE KINETICS

1980 • 21 citations

Intracranial tumors in Enugu, Nigeria

1980 • 21 citations

Extended levodopa release from a subcutaneously implanted polymer matrix in rats

1990 • 20 citations

Glycosylated insulin complexed to Concanavalin A. Biochemical basis for a closed-loop insulin delivery system

1983 • 17 citations

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1975 • 13 citations