Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses

1994 • 1,229 citations

The spaces in a uniform random suspension of fibres

1958 • 1,031 citations

Physiological function of connective tissue polysaccharides.

1978 • 995 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

Correlation between mesh size and equilibrium degree of swelling of polymeric networks

1989 • 617 citations

Statistical theory for the equilibrium distribution of rigid molecules in inert porous networks. Exclusion chromatography

1968 • 469 citations

Equilibrium distribution of flexible polymer chains between a macroscopic solution phase and small voids

1967 • 462 citations

The next frontier of molecular medicine: Delivery of therapeutics

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A Molecular Model of Proteoglycan-Associated Electrostatic Forces in Cartilage Mechanics

1995 • 321 citations

Distribution and Diffusion of Solutes in Articular Cartilage

1970 • 302 citations

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.

1989 • 257 citations

Swelling of the Intervertebral Discin Vitro

1981 • 217 citations

Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice

1993 • 207 citations

Transport of solutes through cartilage: permeability to large molecules.

1976 • 192 citations

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media

1993 • 190 citations

Partitioning and diffusion of proteins and linear polymers in polyacrylamide gels

1996 • 150 citations

Directin vivomeasurement of targeted binding in a human tumor xenograft

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Transvascular drug delivery in solid tumors

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Capillary permeability and how it may change.

1988 • 118 citations

Light transport in tissue: Accurate expressions for one-dimensional fluence rate and escape function based upon Monte Carlo simulation

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Hindered transport in fibrous membranes and gels: Effect of solute size and fiber configuration

1990 • 107 citations

Shared and distinct structural features of interstitial proteoglycans from different bovine tissues revealed by electron microscopy

1989 • 106 citations

Proteoglycans and neoplasia

1988 • 102 citations

Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors.

1984 • 98 citations

Macromolecular basis of globular protein exclusion and of swelling pressure in loose connective tissue (Umbilical cord)

1983 • 96 citations

Determinants of capillary permeability: a review of mechanisms based on single capillary studies in the frog.

1986 • 95 citations

Diffusion and interaction in gels and solutions. 4. Hard sphere Brownian dynamics simulations

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Electron microscopic studies of cartilage proteoglycans

1988 • 90 citations

A Junction-Orifice-Fiber Entrance Layer Model for Capillary Permeability: Application to Frog Mesenteric Capillaries

1994 • 86 citations

Hyaluronidase enhances the activity of Adriamycin in breast cancer models in vitro and in vivo

1992 • 83 citations

Effect of cell arrangement and interstitial volume fraction on the diffusivity of monoclonal antibodies in tissue

1993 • 79 citations

A three-dimensional junction-pore-matrix model for capillary permeability

1992 • 77 citations

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

1991 • 77 citations

Topical Chemoprophylaxis of Superficial Bladder Cancer with Mitomycin C and Adjuvant Hyaluronidase

1992 • 73 citations

Diffusion and interaction in gels and solutions

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THE INTERSTITIAL WATER SPACE OF TUMORS.

1965 • 71 citations

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.

1992 • 70 citations

Effect of composition of experimental solutions on neuronal survival during rat brain slicing

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Interstitial exclusion of albumin in rat tissues measured by a continuous infusion method

1992 • 64 citations

Interstitial exclusion of albumin in rat dermis and subcutis in over- and dehydration

1989 • 57 citations

Estimation of extracellular spaces of smooth muscle using different-sized molecules

1965 • 47 citations

Insulin-like Growth Factor-I and Its Complexes in Normal Human Articular Cartilage: Studies of Partition and Diffusion

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DYNAMICS AND CONTROL OF THE MICROCIRCULATION

1979 • 47 citations

Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma

1997 • 44 citations

Partition and Permeation of Dextran in Polyacrylamide Gel

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Intracellular, Interstitial and Plasma Spaces in the Rat Myocardium

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Structural investigation of loose connective tissue by using a series of dextran fractions as non-interacting macromolecular probes

1977 • 34 citations

Concentration of plasma albumin in its accessible space in postmortem human dermis

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Distribution volumes and macromolecular mobility in rat tail tendon interstitium

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Swelling rate of corneal stroma

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Effect of pressure and stirring on in vitro aortic transmural 125I-albumin transport

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Interferometric Study of Transition from Weak to Strong Penetration of a Polymer Solution into a Porous Silica Bead

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Vascular and extravascular spaces in two transplantable tumors of the rat.

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Predictions of the Swelling-Induced Pre-Stress in Articular Cartilage

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Intratumor distribution of vascular and extravascular spaces

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Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts

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The Effect of a Strongly-Interacting Macromolecular Probe on the Swelling and Exclusion Properties of Loose Connective Tissue

1976 • 6 citations