Conditional gene targeting for cancer gene therapy

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

2000 • 1,092 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.

1994 • 940 citations

Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis

1999 • 788 citations

Reovirus Therapy of Tumors with Activated Ras Pathway

1998 • 740 citations

Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells.

1997 • 589 citations

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

2000 • 572 citations

Suppression of tumor growth through disruption of hypoxia-inducible transcription

2000 • 501 citations

A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.

1995 • 490 citations

Cloning of human telomerase catalytic subunit(hTERT)gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

2002 • 475 citations

Tissue-Specific Targeting of Retroviral Vectors Through Ligand-Receptor Interactions

1994 • 424 citations

Thrombin receptor overexpression in malignant and physiological invasion processes

1998 • 408 citations

An Androgen Response Element in a Far Upstream Enhancer Region Is Essential for High, Androgen-Regulated Activity of the Prostate-Specific Antigen Promoter

1997 • 362 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis.

1999 • 340 citations

Molecular targets for breast cancer therapy and prevention

2001 • 292 citations

Inhibition of melanoma tumor growth in vivo by survivin targeting

2001 • 290 citations

A Novel Tumor-Specific Replication-Restricted Adenoviral Vector for Gene Therapy of Hepatocellular Carcinoma

1999 • 285 citations

A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.

2001 • 277 citations

Mechanisms of Transcriptional Activation of bcl-2 Gene Expression by 17β-Estradiol in Breast Cancer Cells

1999 • 253 citations

Noninvasive gene targeting to the brain

2000 • 251 citations

Adenovirus-mediated regulable target gene expression in vivo

1999 • 249 citations

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene

1999 • 243 citations

Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen

2000 • 238 citations

DNA replication control through interaction of E2F–RB and the origin recognition complex

2001 • 234 citations

Ligand binding regulates the directed movement of β1 integrins on fibroblasts

1996 • 223 citations

Gene therapy: designer promoters for tumour targeting

2000 • 222 citations

Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging.

1991 • 214 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

2001 • 210 citations

Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA

1998 • 203 citations

Vascular Endothelial Growth Factor in Human Colon Cancer: Biology and Therapeutic Implications

2000 • 198 citations

Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy.

1999 • 194 citations

In vitro and in vivo targeting of gene expression to melanoma cells.

1993 • 190 citations

Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model.

1994 • 187 citations

Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.

2000 • 187 citations

Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts

1992 • 186 citations

Progress in Transcriptionally Targeted and Regulatable Vectors for Genetic Therapy

1997 • 180 citations

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

1994 • 176 citations

Use of a Liver-Specific Promoter Reduces Immune Response to the Transgene in Adenoviral Vectors

1999 • 173 citations

Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel.

2001 • 172 citations

Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene

1995 • 171 citations

In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.

1997 • 170 citations

Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector

1997 • 168 citations

Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector.

2000 • 164 citations

Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src

1999 • 161 citations

Transcriptional Regulatory Sequences of Carcinoembryonic Antigen: Identification and Use with Cytosine Deaminase for Tumor-Specific Gene Therapy

1995 • 160 citations

Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer

2000 • 153 citations

Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth.

2000 • 148 citations

Genetic Prodrug Activation Therapy for Breast Cancer: A Phase I Clinical Trial oferbB-2–Directed Suicide Gene Expression

1999 • 147 citations

Vesicular Stomatitis Virus (VSV) Therapy of Tumors

2000 • 145 citations

Targeting of adenoviral vectors through a bispecific single-chain antibody

2000 • 143 citations

Tumor Cell Invasion Is Promoted by Activation of Protease Activated Receptor-1 in Cooperation with the αvβ5 Integrin

2001 • 137 citations

Gene therapy for cancer using tumour-specific prodrug activation.

1994 • 136 citations

Regulation of Multidrug Resistance 1 (MDR1)/P-glycoprotein Gene Expression and Activity by Heat-Shock Transcription Factor 1 (HSF1)

2000 • 134 citations

Glucocorticoids Stimulate p21 Gene Expression by Targeting Multiple Transcriptional Elements within a Steroid Responsive Region of the p21 Promoter in Rat Hepatoma Cells

1998 • 126 citations

DEVELOPMENT OF PROSTATE-SPECIFIC ANTIGEN PROMOTER-BASED GENE THERAPY FOR ANDROGEN-INDEPENDENT HUMAN PROSTATE CANCER

1998 • 123 citations

Adenoviral TNF-α gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft

1998 • 121 citations

Heat-induced gene expression as a novel targeted cancer gene therapy strategy.

2000 • 120 citations

Positive genetic selection for gene disruption in mammalian cells by homologous recombination.

1989 • 120 citations

Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy.

1998 • 119 citations

Characterization of the Cyclooxygenase-2 Promoter in an Adenoviral Vector and Its Application for the Mitigation of Toxicity in Suicide Gene Therapy of Gastrointestinal Cancers

2001 • 118 citations

Tissue-Specific, Tumor-Selective, Replication-Competent Adenovirus Vector for Cancer Gene Therapy

2001 • 116 citations

Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo.

1994 • 113 citations

Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide.

2000 • 107 citations

Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.

1998 • 104 citations

Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models.

1996 • 99 citations

Use of Transcriptional Regulatory Sequences of Telomerase (hTER and hTERT) for Selective Killing of Cancer Cells

2000 • 90 citations

Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.

2000 • 87 citations

Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting

1996 • 87 citations

Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras

1997 • 86 citations

Evaluation of Relative Promoter Strength in Primary Hepatocytes Using Optimized Lipofection

1991 • 86 citations

Cell-Type-Specific and Regulatable Transgenesis in the Adult Brain: Adenovirus-Encoded Combined Transcriptional Targeting and Inducible Transgene Expression

2000 • 85 citations

Factors controlling the expression of mouse mammary tumour virus

1992 • 85 citations

Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGF-beta type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms.

1995 • 85 citations

Endoglin expression as a measure of microvessel density in cervical cancer

2000 • 84 citations

Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene

1993 • 84 citations

A Novel, Conditionally Replicative Adenovirus for the Treatment of Breast Cancer That Allows Controlled Replication of E1a-Deleted Adenoviral Vectors

2000 • 84 citations

Hypoxia response elements.

1997 • 81 citations

Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity.

2000 • 81 citations

An Androgen Response Element in a Far Upstream Enhancer Region Is Essential for High, Androgen-Regulated Activity of the Prostate-Specific Antigen Promoter

1997 • 77 citations

Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter.

2000 • 75 citations

Hexokinase Type II: A Novel Tumor-Specific Promoter for Gene-Targeted Therapy Differentially Expressed and Regulated in Human Cancer Cells

1999 • 73 citations

Mammary gland-specific nuclear factor activity is positively regulated by lactogenic hormones and negatively by milk stasis.

1992 • 72 citations

Evaluation of E1-Mutant Adenoviruses as Conditionally Replicating Agents for Cancer Therapy

2000 • 72 citations

Strategy for achieving selective killing of carcinomas.

1994 • 71 citations

Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells.

1996 • 69 citations

Activation of the Radiosensitive EGR-1 Promoter Induces Expression of the Herpes Simplex Virus Thymidine Kinase Gene and Sensitivity of Human Glioma Cells to Ganciclovir

1995 • 69 citations

BCR-ABL Antisense Oligodeoxynucleotide In Vitro Purging and Autologous Bone Marrow Transplantation for Patients With Chronic Myelogenous Leukemia in Advanced Phase

1998 • 69 citations

Inducible control of gene expression: prospects for gene therapy

1998 • 68 citations

Transcriptional Targeting to Anterior Pituitary Lactotrophic Cells Using Recombinant Adenovirus Vectors in Vitro and in Vivo in Normal and Estrogen/Sulpiride-Induced Hyperplasic Anterior Pituitaries*

2000 • 68 citations

C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis.

1995 • 67 citations

Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors

1999 • 67 citations

Regulation of secretory leukocyte proteinase inhibitor (SLPI) production by human bronchial epithelial cells: increase of cell-associated SLPI by neutrophil elastase.

2000 • 66 citations

Retargeting to EGFR Enhances Adenovirus Infection Efficiency of Squamous Cell Carcinoma

1999 • 66 citations

Pseudotyped retroviral vectors for studies of human gene therapy

1995 • 65 citations

Inverse Targeting of Retroviral Vectors: Selective Gene Transfer in a Mixed Population of Hematopoietic and Nonhematopoietic Cells

1998 • 65 citations

p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14ARF–MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells

2000 • 65 citations

Response of heat shock element within the human HSP70 promoter to mutated p53 genes.

1995 • 63 citations

Endothelial Cell-Specific Expression of Tumor Necrosis Factor-αfrom the KDR or E-Selectin Promoters Following Retroviral Delivery

1997 • 62 citations

Tissue-Specific Gene Expression from Mo-MLV Retroviral Vectors with Hybrid LTRs Containing the Murine Tyrosinase Enhancer/Promoter

1995 • 61 citations

Transcriptional Targeting of Retroviral Vectors to the Erythroblastic Progeny of Transduced Hematopoietic Stem Cells

1999 • 61 citations

Ligand-Dependent Regulation of Plasmid-Based Transgene Expression in Vivo

1999 • 59 citations

Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.

1999 • 57 citations

Inhibition of melanoma tumor growth in vivo by survivin targeting

2001 • 57 citations

Eradication of Breast Cancer Xenografts by Hyperthermic Suicide Gene Therapy under the Control of the Heat Shock Protein Promoter

2000 • 56 citations

Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells

1999 • 56 citations

Co-expression of vascular endothelial growth factor (VEGF) and its receptors (flk-1 and flt-1) in hormone-induced mammary cancer in the Noble rat

1999 • 55 citations

Inverse Targeting of Retroviral Vectors: Selective Gene Transfer in a Mixed Population of Hematopoietic and Nonhematopoietic Cells

1998 • 54 citations

Tumor-specific gene expression in hepatic metastases by a replication-activated adenovirus vector

2001 • 52 citations

Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector.

1990 • 51 citations

Development of Systemic Immunity to Glioblastoma Multiforme Using Tumor Cells Genetically Engineered to Express the Membrane-Associated Isoform of Macrophage Colony-Stimulating Factor

1999 • 49 citations

Surfactant Protein A-Directed Toxin Gene Kills Lung Cancer Cells In Vitro

1994 • 48 citations

A regulatory system for target gene expression

1998 • 48 citations

Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo.

1995 • 48 citations

Breast cancer-specific expression of the Candida albicans cytosine deaminase gene using a transcriptional targeting approach

2000 • 46 citations

Augmenting Transgene Expression from Carcinoembryonic Antigen (CEA) Promoter via a GAL4 Gene Regulatory System

2001 • 46 citations

Hypoxia response elements

2004 • 45 citations

The dominant negative H-ras mutant, N116Y, suppresses growth of metastatic human pancreatic cancer cells in the liver of nude mice

2000 • 44 citations

Prostate-specific amplification of expanded polyglutamine expression: a novel approach for cancer gene therapy.

1998 • 42 citations

Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.

1996 • 42 citations

Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation.

1994 • 41 citations

Differential effect on U937 cell differentiation by targeting transcriptional factors implicated in tissue- or stage-specific induced integrin expression

1999 • 41 citations

Upregulation of endoglin (CD105) expression during childhood brain tumor-related angiogenesis. Anti-angiogenic therapy.

1998 • 40 citations

Endothelial Cell-Specific Transcriptional Targeting from a Hybrid Long Terminal Repeat Retrovirus Vector Containing Human Prepro-Endothelin-1 Promoter Sequences

1999 • 40 citations

A regulatory network for the efficient control of transgene expression

2000 • 39 citations

Tumor endothelium-specific transgene expression directed by vascular endothelial growth factor receptor-2 (Flk-1) promoter/enhancer sequences.

2000 • 37 citations

Intracellular Antibodies Against HIV-1 Envelope Protein for AIDS Gene Therapy. Dana Farber Cancer Institute, Boston, Massachusetts

1998 • 34 citations

p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14ARF–MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells

2000 • 34 citations

Expression of the diphtheria toxin A-chain coding sequence under the control of promoters and enhancers from immunoglobulin genes as a means of directing toxicity to B-lymphoid cells.

1991 • 34 citations

Engineering Tissue-Specific Expression of a Recombinant Adenovirus: Selective Transgene Transcription in the Pancreas Using the Amylase Promoter

1997 • 33 citations

Endothelium-specific expression of an E-selectin promoter recombinant adenoviral vector.

1998 • 33 citations

In vivo Adenovirus‐mediated Prodrug Gene Therapy for Carcinoembryonic Antigen‐producing Pancreatic Cancer

1998 • 30 citations

mdr1 promoter-driven tumor necrosis factor-α expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors

2000 • 29 citations

Tumour-specific arginine vasopressin promoter activation in small-cell lung cancer

1999 • 28 citations

Targeting gene expression to tumor cells with loss of wild-type p53 function

2000 • 27 citations

Molecular Chemotherapy for Breast Cancer

1999 • 27 citations

E-box motifs within the human vasopressin gene promoter contribute to a major enhancer in small-cell lung cancer

1999 • 27 citations

Mammary gland-specific nuclear factor activity is positively regulated by lactogenic hormones and negatively by milk stasis

1992 • 24 citations

Liposomes modified with a synthetic Arg-Gly-Asp mimetic inhibit lung metastasis of B16BL6 melanoma cells

2000 • 24 citations

Identification of the secretory leukocyte protease inhibitor (SLPI) as a target of IRF-1 regulation

1999 • 22 citations

In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.

1998 • 22 citations

Recent Advances in Cancer Research: Drug Targeting Without the Use of Monoclonal Antibodies

1989 • 18 citations

Tumor-specific gene expression.

1994 • 18 citations

Adenovirus-mediated suicide gene transfer to small cell lung carcinoma using a tumor-specific promoter.

2001 • 18 citations

Transcriptional Targeting to Anterior Pituitary Lactotrophic Cells Using Recombinant Adenovirus Vectors in Vitro and in Vivo in Normal and Estrogen/Sulpiride-Induced Hyperplasic Anterior Pituitaries

2000 • 17 citations

Therapeutic Strategies Using c‐erb B‐2 Promoter‐Controlled Drug Activationa

1994 • 16 citations

Simple method to prepare cationic multilamellar liposomes for efficient transfection of human interferon-? gene to human glioma cells

1994 • 14 citations

Production of Secretory Leucocyte Protease Inhibitor (SLPI) in Human Pancreatic β-Cells

1999 • 13 citations

High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achieved by Adenovirus Mediated Gene Transfer

1998 • 10 citations

Bone tissue specific transcriptional control

2000 • 9 citations

Inhibition of in vitro proliferation of chronic myelogenous leukemia progenitor cells by c-myb antisense oligodeoxynucleotides.

1996 • 8 citations

E-box motifs within the human vasopressin gene promoter contribute to a major enhancer in small-cell lung cancer

1999 • 7 citations

Growth inhibition of Ph+ progenitor cells from CML patients using the tyrosine kinase inhibitor CGP57148B.

2000 • 6 citations

[Transcriptional expression of apoptosis suppression gene bcl-2 in non-small cell lung carcinoma].

2000 • 3 citations

[The clinical study on secretory leukoprotease inhibitor (SLPI) in sera of patients with various pulmonary diseases].

1995 • 2 citations

Deleted Work

1955 • 0 citations