Signaling antibodies complexed with adenovirus circumvent CAR and integrin interactions and improve gene delivery

Integrin Signaling

1999 • 3,705 citations

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

1997 • 3,081 citations

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses

1997 • 1,212 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

1994 • 829 citations

αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection

1999 • 700 citations

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

1993 • 669 citations

Targeted gene delivery by tropism-modified adenoviral vectors

1996 • 431 citations

Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism

1996 • 392 citations

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

1992 • 380 citations

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

1994 • 373 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

1996 • 327 citations

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.

1992 • 319 citations

Adenovirus Endocytosis via α _v Integrins Requires Phosphoinositide-3-OH Kinase

1998 • 249 citations

INTRACELLULAR PATHOGENS AND THE ACTIN CYTOSKELETON

1998 • 248 citations

Adenovirus Endocytosis Requires Actin Cytoskeleton Reorganization Mediated by Rho Family GTPases

1998 • 244 citations

Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling

1999 • 237 citations

Adenovirus Internalization and Infection Require Dynamin

1998 • 214 citations

RGD Inclusion in the Hexon Monomer Provides Adenovirus Type 5-Based Vectors with a Fiber Knob-Independent Pathway for Infection

1999 • 190 citations

Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway

1995 • 188 citations

Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

1997 • 184 citations

The ‘adenobody’ approach to viral targeting: specific and enhanced adenoviral gene delivery

1997 • 152 citations

Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16

1997 • 132 citations

Gene therapy

1997 • 130 citations

Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes

1996 • 117 citations

A Helper-Independent Adenovirus Vector with E1, E3, and Fiber Deleted: Structure and Infectivity of Fiberless Particles

1999 • 109 citations

Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice.

1999 • 102 citations

Interactions of Soluble Recombinant Integrin αvβ5 with Human Adenoviruses

1998 • 92 citations

Fiberless Recombinant Adenoviruses: Virus Maturation and Infectivity in the Absence of Fiber

1999 • 88 citations

Gene therapy for cancer

1999 • 87 citations

A novel and rapid cloning method for the T-cell receptor variable region sequences

1991 • 65 citations

Targeted Adenoviral Vectors for Cancer Gene Therapy

1998 • 60 citations

Ultrastructural and Immunofluorescence Studies of Early Events in Adenovirus-HeLa Cell Interactions

1983 • 60 citations

Effects of growth factors on phosphatidylinositol‐3 kinase in astroglial cells

1995 • 23 citations

Genetic engineering of a recombinant fusion possessing anti-tumor F(ab′)2 and tumor necrosis factor

1997 • 15 citations