The B7 and CD28 receptor families

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Leukocyte Typing II

1986 • 688 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

1993 • 369 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.

1992 • 342 citations

Costimulation of T cells for tumor immunity

1993 • 324 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

1993 • 312 citations

Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

1992 • 285 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

1993 • 259 citations

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

1993 • 242 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

1994 • 210 citations

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1991 • 194 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells.

1986 • 165 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells

1993 • 153 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.

1992 • 118 citations

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

1989 • 117 citations

CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.

1993 • 116 citations

Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation.

1992 • 115 citations

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1992 • 103 citations

Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo.

1993 • 103 citations

CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway.

1992 • 92 citations

A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7.

1993 • 91 citations

IL-4 and IL-2 upregulate the expression of antigen B7, the B cell counterstructure to T cell CD28: an amplification mechanism for T-B cell interactions

1991 • 85 citations

Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation

1993 • 84 citations

Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells.

1987 • 80 citations

Raf-1 is required for T cell IL2 production.

1993 • 78 citations

Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection.

1991 • 72 citations

Monomeric homologue of mammalian CD28 is expressed on chicken T cells.

1994 • 69 citations

Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes.

1988 • 68 citations

Activation of src Family Kinase lck Following CD28 Crosslinking in the Jurkat Leukemic Cell Line

1994 • 59 citations

CD28 ligation by monoclonal antibodies or B7/BB1 provides an accessory signal for the cyclosporin A-resistant generation of cytotoxic T cell activity.

1993 • 56 citations

IL-1 alpha is produced by T lymphocytes activated via the CD2 plus CD28 pathways.

1991 • 53 citations

Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells.

1993 • 51 citations

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide

1993 • 51 citations

The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction.

1994 • 47 citations

Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4⁺ T cells by the murine B7 antigen

1993 • 44 citations

Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity

1993 • 44 citations

Phorbol-12-Myristate-13-Acetate-Treated Human Keratinocytes Express B7-Like Molecules That Serve a Costimulatory Role in T-Cell Activation

1993 • 42 citations

Rapid activation of C-Raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T cells.

1993 • 40 citations

Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface

1989 • 39 citations

Molecular linkage of the human CTLA4 and CD28 Ig-superfamily genes in yeast artificial chromosomes

1992 • 38 citations

CD28-stimulated IL-2 gene expression in jurkat T cells occurs in part transcriptionally and is cyclosporine-A sensitive

1992 • 36 citations

Regulation of interleukin‐4 production in human mononuclear cells

1992 • 35 citations

Interleukin-1 and B7/CD28 Interaction Regulate Interleukin-6 Production by Human T Cells

1994 • 26 citations

Interleukin-7 specifically induces the B7/BB1 antigen on human cord blood and peripheral blood T cells and T cell clones

1993 • 24 citations

CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

1992 • 24 citations

Contributions of the CD2 and CD28 T lymphocyte activation pathways to the regulation of the expression of the colony-stimulating factor (CSF-1) gene.

1992 • 16 citations

Dissociation between early and late events in T cell activation mediated through CD28 surface molecule

1991 • 10 citations