Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Maintenance of in Vivo Tolerance by Persistence of Antigen

1992 • 209 citations

Tyrosyl Phosphorylation and Activation of MAP Kinases by p56^lck

1992 • 140 citations

Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck).

1989 • 112 citations

Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.

1993 • 99 citations

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

1992 • 89 citations

Anti-proliferative effect of IFN-gamma in immune regulation. IV. Murine CTL clones produce IL-3 and GM-CSF, the activity of which is masked by the inhibitory action of secreted IFN-gamma.

1990 • 47 citations

Anergized T cell clones retain their cytolytic ability.

1993 • 44 citations