Mitochondria: The Missing Link Between Preconditioning and Neuroprotection

Free radicals and antioxidants in normal physiological functions and human disease

2006 • 13,251 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

The Pathophysiology of Mitochondrial Cell Death

2004 • 3,258 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

2005 • 1,425 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Mitochondria in Neuroplasticity and Neurological Disorders

2008 • 964 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Mitochondria take center stage in aging and neurodegeneration

2005 • 934 citations

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

2008 • 874 citations

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

2005 • 793 citations

Ischemic tolerance and endogenous neuroprotection

2003 • 790 citations

ATP-sensitive K+ channel in the mitochondrial inner membrane

1991 • 746 citations

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

2005 • 743 citations

Cerebral preconditioning and ischaemic tolerance

2006 • 740 citations

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

2005 • 717 citations

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

1998 • 715 citations

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

2000 • 694 citations

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

2005 • 597 citations

Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

2002 • 579 citations

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

2009 • 567 citations

Mitochondria as all‐round players of the calcium game

2000 • 556 citations

Mitochondria as a Pharmacological Target

2002 • 542 citations

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

2007 • 542 citations

Role of the mitochondrial membrane permeability transition in cell death

2006 • 531 citations

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

2007 • 530 citations

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

2003 • 506 citations

Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression

1998 • 488 citations

Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

1998 • 474 citations

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells

2007 • 420 citations

Roles of Mitochondria in Health and Disease

2004 • 414 citations

The role of mitochondria in protection of the heart by preconditioning

2007 • 378 citations

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

2009 • 375 citations

Mitochondrial Participation in Ischemic and Traumatic Neural Cell Death

2000 • 350 citations

Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

2003 • 345 citations

‘Ischemic tolerance’ phenomenon detected in various brain regions

1991 • 341 citations

Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1 Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia

2007 • 336 citations

To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

2003 • 296 citations

Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP111-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

2003 • 291 citations

Identification and Properties of a Novel Intracellular (Mitochondrial) ATP-sensitive Potassium Channel in Brain

2001 • 282 citations

Phosphoinositide-3-Kinase/Akt Survival Signal Pathways Are Implicated in Neuronal Survival After Stroke

2006 • 279 citations

The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide

2003 • 245 citations

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease

2002 • 243 citations

Activation of Mitochondrial ATP-Dependent Potassium Channels Protects Neurons against Ischemia-Induced Death by a Mechanism Involving Suppression of Bax Translocation and Cytochrome c Release

2002 • 214 citations

CREB-Mediated Bcl-2 Protein Expression after Ischemic Preconditioning

2005 • 209 citations

Mitochondrial KATP channels: role in cardioprotection

2002 • 208 citations

Preconditioning Reprograms the Response to Ischemic Injury and Primes the Emergence of Unique Endogenous Neuroprotective Phenotypes

2007 • 197 citations

Mitochondrial oversight of cellular Ca2+ signaling

1998 • 188 citations

Uncoupling Protein 2 Prevents Neuronal Death Including that Occurring during Seizures: A Mechanism for Preconditioning

2003 • 188 citations

Neuroprotection by Hypoxic Preconditioning Involves Oxidative Stress-Mediated Expression of Hypoxia-Inducible Factor and Erythropoietin

2005 • 176 citations

Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance

2006 • 176 citations

Adaptation of adult brain tissue to anoxia and hypoxia in vitro

1986 • 174 citations

Endogenous neuroprotection: Mitochondria as gateways to cerebral preconditioning?

2008 • 157 citations

Abortive apoptosis in Alzheimer's disease

2001 • 157 citations

Respiratory Chain Inhibition Induces Tolerance to Focal Cerebral Ischemia

1999 • 146 citations

Diazoxide induces delayed pre‐conditioning in cultured rat cortical neurons

2003 • 141 citations

Preconditioning‐induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor‐κB

2001 • 137 citations

Protection of oxidative preconditioning against apoptosis induced by H2O2 in PC12 cells: Mechanisms via MMP, ROS, and Bcl-2

2005 • 132 citations

Cerebral ischemic preconditioning

2002 • 129 citations

Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria

2001 • 123 citations

Oxidative Damage to RNA in Neurodegenerative Diseases

2006 • 123 citations

Hypoxia‐inducible factor 1: a new hope to counteract neurodegeneration?

2009 • 123 citations

MitoK_ATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat

2002 • 120 citations

Ischemic Preconditioning Targets the Respiration of Synaptic Mitochondria via Protein Kinase Cε

2008 • 119 citations

Effect of amyloid β‐peptide on permeability transition pore: A comparative study

2002 • 116 citations

Mitochondrial K_ATP channel openers activate the ERK kinase by an oxidant-dependent mechanism

2002 • 115 citations

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells

2002 • 113 citations

Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders

2007 • 108 citations

Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: Mitochondrial targeted preconditioning

2008 • 107 citations

Mitochondrial Potassium Channel Opener Diazoxide Preserves Neuronal-Vascular Function After Cerebral Ischemia in Newborn Pigs

1999 • 105 citations

Preconditioning-induced neuroprotection is mediated by reactive oxygen species

2000 • 103 citations

Role of Reactive Oxygen Species and Protein Kinase C in Ischemic Tolerance in the Brain

2005 • 101 citations

Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation after Transient Focal Cerebral Ischemia in Mice

2001 • 99 citations

Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity

2009 • 99 citations

K+ channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity

1996 • 96 citations

Mitochondrial Uncoupling Proteins in the Central Nervous System

2005 • 95 citations

Remote organ ischemic preconditioning protect brain from ischemic damage following asphyxial cardiac arrest

2006 • 95 citations

Potassium channel openers depolarize hippocampal mitochondria

2001 • 94 citations

ɛPKC phosphorylates the mitochondrial K+ATP channel during induction of ischemic preconditioning in the rat hippocampus

2007 • 90 citations

Generation of hydrogen peroxide during brief oxygen‐glucose deprivation induces preconditioning neuronal protection in primary cultured neurons

2005 • 86 citations

Opening of Mitochondrial ATP-Sensitive Potassium Channels Is a Trigger of 3-Nitropropionic Acid–Induced Tolerance to Transient Focal Cerebral Ischemia in Rats

2003 • 86 citations

Apoptosis in Alzheimer Disease: A Mathematical Improbability

2006 • 86 citations

Neuroprotective Effects of Ischemic Preconditioning in Brain Mitochondria Following Cerebral Ischemia

2004 • 78 citations

ALTERATIONS IN LYSOSOMES (INTRACELLULAR ENZYMES) DURING SHOCK; EFFECTS OF PRECONDITIONING (TOLERANCE) AND PROTECTIVE DRUGS

1964 • 74 citations

Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes

2008 • 69 citations

Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2

2009 • 67 citations

The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore

2006 • 66 citations

The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning

2004 • 66 citations

The Mitochondrial K_ATP Channel Opener BMS-191095 Reduces Neuronal Damage after Transient Focal Cerebral Ischemia in Rats

2006 • 62 citations

Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels

2007 • 62 citations

Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons

2008 • 61 citations

Activation of mitochondrial ATP‐sensitive potassium channels increases cell viability against rotenone‐induced cell death

2003 • 59 citations

Preconditioning by an in situ administration of hydrogen peroxide: Involvement of reactive oxygen species and mitochondrial ATP-dependent potassium channel in a cerebral ischemia–reperfusion model

2008 • 58 citations

NO‐induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn‐SOD activity and expression via RAS/ERK1/2 pathway

2007 • 56 citations

Cellular and Molecular Neurobiology of Brain Preconditioning

2009 • 56 citations

Activation of adenosine triphosphate‐sensitive potassium channels confers protection against rotenone‐induced cell death: Therapeutic implications for Parkinson's disease

2002 • 55 citations

4-Hydroxy-2-nonenal and uncoupling proteins: an approach for regulation of mitochondrial ROS production

2007 • 54 citations

Mitochondria: The Missing Link Between Preconditioning and Neuroprotection

2010 • 53 citations

ROS-Independent Preconditioning in Neurons via Activation of mitoK_ATP Channels by BMS-191095

2008 • 50 citations

K_ATP channel openers protect mesencephalic neurons against MPP⁺‐induced cytotoxicity via inhibition of ROS production

2009 • 45 citations

Diazoxide prevents mitochondrial swelling and Ca 2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs

2004 • 44 citations

Immediate neuronal preconditioning by NS1619

2009 • 41 citations

PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis

2004 • 40 citations

Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats

2005 • 38 citations

Reconstitution of brain mitochondria inner membrane into planar lipid bilayer

2005 • 36 citations

The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells

2005 • 32 citations

Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats

2007 • 32 citations

Potassium channel openers prevent β-amyloid toxicity in bovine vascular endothelial cells

2000 • 28 citations

Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: role of tumour necrosis factor-α?

2001 • 27 citations

Diazoxide Reverses the Enhanced Expression of KATP Subunits in Cholinergic Neurons Caused by Exposure to Aβ1-42

2009 • 16 citations

Apoptosis and Alzheimer’s Disease

1997 • 14 citations

Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model

2008 • 14 citations

Diazoxide and Nω-nitro-L-arginine counteracted Aβ1-42-induced cytotoxicity

2004 • 12 citations

Hydrogen peroxide preconditioning protects PC12 cells against apoptosis induced by oxidative stress.

2005 • 9 citations

The mitochondrial K[ATP] channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats

2009 • 3 citations