Diazoxide induces delayed pre‐conditioning in cultured rat cortical neurons

Mitochondria, oxygen free radicals, disease and ageing

2000 • 1,054 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury

1993 • 694 citations

Opening of Mitochondrial K _ATP Channels Triggers the Preconditioned State by Generating Free Radicals

2000 • 666 citations

Mitochondria as a Pharmacological Target

2002 • 542 citations

Astrocytes protect neurons from hydrogen peroxide toxicity

1996 • 541 citations

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

1999 • 502 citations

Ischemic Preconditioning: From Adenosine Receptor to K_ATP Channel

2000 • 469 citations

The Mitochondrial K Channel as a Receptor for Potassium Channel Openers

1996 • 447 citations

Diazoxide-Induced Cardioprotection Requires Signaling Through a Redox-Sensitive Mechanism

2001 • 396 citations

Bioenergetic consequences of opening the ATP-sensitive K⁺channel of heart mitochondria

2001 • 355 citations

ATP‐sensitive K⁺ channel openers prevent Ca²⁺ overload in rat cardiac mitochondria

1999 • 353 citations

ATP-sensitive K⁺channels in pancreatic, cardiac, and vascular smooth muscle cells

1998 • 349 citations

K_ATP channel‐independent targets of diazoxide and 5‐hydroxydecanoate in the heart

2002 • 323 citations

Identification and Properties of a Novel Intracellular (Mitochondrial) ATP-sensitive Potassium Channel in Brain

2001 • 282 citations

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

1993 • 265 citations

Ischaemic preconditioning: present position and future directions

1998 • 260 citations

State-dependent Inhibition of the Mitochondrial KATP Channel by Glyburide and 5-Hydroxydecanoate

1998 • 257 citations

Evaluation of methods for measuring cellular glutathione content using flow cytometry

1994 • 245 citations

Structure-activity relationships of K+ channel openers

1990 • 237 citations

Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels

2000 • 231 citations

The effects of ischaemic preconditioning, diazoxide and 5‐hydroxydecanoate on rat heart mitochondrial volume and respiration

2002 • 221 citations

Activation of Mitochondrial ATP-Dependent Potassium Channels Protects Neurons against Ischemia-Induced Death by a Mechanism Involving Suppression of Bax Translocation and Cytochrome c Release

2002 • 214 citations

Mitochondrial KATP channels: role in cardioprotection

2002 • 208 citations

Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation

2002 • 202 citations

Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP

1999 • 183 citations

Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria

2003 • 181 citations

Respiratory Chain Inhibition Induces Tolerance to Focal Cerebral Ischemia

1999 • 146 citations

Preconditioning‐induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor‐κB

2001 • 137 citations

Mitochondrial KATP channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation

2001 • 123 citations

MitoK_ATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat

2002 • 120 citations

Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion

2001 • 120 citations

KATP channel openers, adenosine agonists and epileptic preconditioning are stress signals inducing hippocampal neuroprotection

2000 • 117 citations

Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection

2003 • 109 citations

Mitochondrial Potassium Channel Opener Diazoxide Preserves Neuronal-Vascular Function After Cerebral Ischemia in Newborn Pigs

1999 • 105 citations

Dual roles of mitochondrial K_ATP channels in diazoxide-mediated protection in isolated rabbit hearts

2001 • 104 citations

Delayed preconditioning of myocardium: current perspectives

2001 • 101 citations

K+ channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity

1996 • 96 citations

Potassium channel openers depolarize hippocampal mitochondria

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The Potassium Channel Opener (−)‐Cromakalim Prevents Glutamate‐Induced Cell Death in Hippocampal Neurons

1997 • 91 citations

Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection31The Thoracic Surgery Directors Association (TSDA) Resident Research Award, sponsored by Medtronic, Inc, was established in 1990 to encourage resident research in cardiothoracic surgery. Abstracts submitted to The Society of Thoracic Surgeons (STS) Program Committee representing research performed by residents were forwarded to the TSDA to be considered for this award. The abstracts were reviewed by …

2001 • 90 citations

β‐Oxidation of 5‐hydroxydecanoate, a Putative Blocker of Mitochondrial ATP‐Sensitive Potassium Channels

2003 • 88 citations

Opening of Mitochondrial ATP-Sensitive Potassium Channels Is a Trigger of 3-Nitropropionic Acid–Induced Tolerance to Transient Focal Cerebral Ischemia in Rats

2003 • 86 citations

Diazoxide, an inhibitor of succinate oxidation

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Diazoxide protects mitochondria from anoxic injury: Implications for myopreservation

2001 • 83 citations

Differential role of sarcolemmal and mitochondrial K_ATPchannels in adenosine-enhanced ischemic preconditioning

2000 • 83 citations

Cannabinoid and Kappa Opioid Receptors Reduce Potassium K Current via Activation of G_s Proteins in Cultured Hippocampal Neurons

2000 • 82 citations

Mitochondrial KATPChannel Opening is Important During Index Ischemia and Following Myocardial Reperfusion in Ischemic Preconditioned Rat Hearts

2001 • 76 citations

Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K_ATPchannel

2001 • 73 citations

Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia

1999 • 71 citations

Modulation of mitochondrial succinate dehydrogenase activity, mechanism and function

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Opening of ATP-sensitive potassium channels by cromakalim confers tolerance against chemical ischemia in rat neuronal cultures

1998 • 60 citations

Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia

2002 • 59 citations

Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats

2002 • 57 citations

Protein Kinase C Control of Gene Expression

2001 • 54 citations

Possible role of the superoxide anion in the development of neuronal tolerance following ischaemic preconditioning in rats

2000 • 46 citations

Activation of ATP-sensitive potassium channels decreases neuronal injury caused by chemical hypoxia

1997 • 41 citations

ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus

2002 • 38 citations

Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning.

2001 • 35 citations

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

2000 • 17 citations