Mitochondrial Uncoupling Proteins in the Central Nervous System

Brown Adipose Tissue: Function and Physiological Significance

2004 • 5,925 citations

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

1997 • 1,695 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

Superoxide activates mitochondrial uncoupling proteins

2002 • 1,364 citations

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

2000 • 1,068 citations

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

2004 • 1,019 citations

Neurodegenerative diseases and oxidative stress

2003 • 986 citations

Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

2001 • 916 citations

Uncoupling: new approaches to an old problem of bioenergetics

1998 • 877 citations

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 • 854 citations

Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain

1970 • 854 citations

A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

1997 • 756 citations

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

2004 • 748 citations

The mitochondrial transporter family (SLC25): physiological and pathological implications

2004 • 725 citations

Kainate, a double agent that generates seizures: two decades of progress

2000 • 633 citations

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

2003 • 587 citations

Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

2004 • 533 citations

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

2003 • 506 citations

Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation

2001 • 472 citations

The ketogenic diet increases mitochondrial uncoupling protein levels and activity

2004 • 391 citations

UCP4, a novel brain‐specific mitochondrial protein that reduces membrane potential in mammalian cells

1999 • 373 citations

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

2003 • 358 citations

Coenzyme Q is an obligatory cofactor for uncoupling protein function

2000 • 327 citations

Uncoupling proteins 2 and 3 are highly active H ⁺ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

2001 • 318 citations

BMCP1, a Novel Mitochondrial Carrier with High Expression in the Central Nervous System of Humans and Rodents, and Respiration Uncoupling Activity in Recombinant Yeast

1998 • 313 citations

Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species 1,2 1Guest Editor: Harry Ischiropoulos 2This article is part of a series of reviews on “Reactive Nitrogen Species, Tyrosine Nitration and Cell Signaling.” The full list of papers may be found on the homepage of the journal.

2002 • 301 citations

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

2003 • 296 citations

Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling

2003 • 289 citations

Reactive Oxygen Species and Signal Transduction

2001 • 286 citations

Uncoupling Protein 2 Prevents Neuronal Death Including that Occurring during Seizures: A Mechanism for Preconditioning

2003 • 188 citations

Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers

1999 • 177 citations

The mitochondrial uncoupling proteins.

2002 • 176 citations

Uncoupling Proteins Prevent Glucose-Induced Neuronal Oxidative Stress and Programmed Cell Death

2004 • 175 citations

Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins

2001 • 167 citations

Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production

2004 • 166 citations

No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria

2002 • 162 citations

Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.

1998 • 155 citations

Activation and Function of Mitochondrial Uncoupling Protein in Plants

2004 • 152 citations

Amino acid effects on translational repressor 4E-BP1 are mediated primarily by<scp>l</scp>-leucine in isolated adipocytes

1998 • 150 citations

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

1999 • 145 citations

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

2003 • 132 citations

Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats

2002 • 127 citations

How do uncoupling proteins uncouple?

2000 • 124 citations

Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury

2002 • 121 citations

Regulation of Cellular Oncosis by Uncoupling Protein 2

2002 • 119 citations

Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice

2002 • 118 citations

Coenzyme Q Induces Nigral Mitochondrial Uncoupling and Prevents Dopamine Cell Loss in a Primate Model of Parkinson’s Disease

2003 • 114 citations

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells

2002 • 113 citations

BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production

2001 • 111 citations

Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4

2001 • 110 citations

Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells

2003 • 109 citations

Uncoupling protein--a useful energy dissipator.

1999 • 109 citations

Reconstitution of Recombinant Uncoupling Proteins

2003 • 108 citations

Fasting and Leptin Modulate Adipose and Muscle Uncoupling Protein: Divergent Effects Between Messenger Ribonucleic Acid and Protein Expression¹

1999 • 108 citations

Mitochondrial uncoupling proteins – facts and fantasies

2004 • 107 citations

A potentially critical role of phospholipases in central nervous system ischemic, traumatic, and neurodegenerative disorders

2004 • 107 citations

Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels

2004 • 107 citations

Distribution of the uncoupling protein 2 mRNA in the mouse brain

1998 • 104 citations

Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels

1998 • 99 citations

Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women

2004 • 97 citations

Activating ω-6 Polyunsaturated Fatty Acids and Inhibitory Purine Nucleotides Are High Affinity Ligands for Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3

2003 • 88 citations

Uncoupling protein 2 in the brain: distribution and function

2001 • 86 citations

Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector

2003 • 78 citations

Translation-State Analysis of Gene Expression in Mouse Brain after Focal Ischemia

2004 • 61 citations

Quantitative RT-PCR Analysis of Uncoupling Protein Isoforms in Mouse Brain Cortex: Methodological Optimization and Comparison of Expression with Brown Adipose Tissue and Skeletal Muscle

2004 • 59 citations

Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats

1999 • 57 citations

Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria

2004 • 56 citations

Activation of the Uncoupling Protein by Fatty Acids is Modulated by Mutations in the C‐Terminal Region of the Protein

1996 • 56 citations

Role of arachidonic acid and other free fatty acids in mitochondrial dysfunction in brain ischemia

1988 • 55 citations

Uncoupling protein 2: a novel player in neuroprotection

2003 • 54 citations

Effects of dietary conjugated linoleic acid on the expression of uncoupling proteins in mice and rats

2002 • 47 citations

Functional Characterization of a Drosophila Mitochondrial Uncoupling Protein

2004 • 43 citations

Effects of ischemia and exogenous fatty acids on the energy metabolism in brain mitochondria.

1972 • 42 citations

RELATIONSHIP BETWEEN CEREBRAL ENERGY FAILURE AND FREE FATTY ACID ACCUMULATION FOLLOWING PROLONGED BRAIN ISCHEMIA

1978 • 41 citations

Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold

2002 • 38 citations

Effects of Growth Hormone (GH) on mRNA Levels of Uncoupling Proteins 1, 2, and 3 in Brown and White Adipose Tissues and Skeletal Muscle in Obese Mice

2004 • 37 citations

Functional expression of the rat brown adipose tissue uncoupling protein in Saccharomyces cerevisiae

1992 • 35 citations

Two uncoupling protein genes of rice ( Oryza sativa L.): molecular study reveals the defects in the pre-mRNA processing for the heat-generating proteins of the subtropical cereal

2002 • 31 citations

Fasting and Leptin Modulate Adipose and Muscle Uncoupling Protein: Divergent Effects Between Messenger Ribonucleic Acid and Protein Expression

1999 • 31 citations

Uncoupling protein 2 influences dopamine secretion in PC12h cells

2003 • 27 citations

Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: role of tumour necrosis factor-α?

2001 • 27 citations

Proton and calcium circuits across the mitochondrial inner membrane

1984 • 25 citations

A = 5 - 20

2005 • 25 citations

Influence of Severe Hypoglycemia on Mitochondrial and Plasma Membrane Function in Rat Brain

1982 • 24 citations

Uncoupling protein‐3 sensitizes cells to mitochondrial‐dependent stimulus of apoptosis

2004 • 24 citations

Molecular cloning of rat brain mitochondrial carrier protein-1 cDNA and its up-regulation during postnatal development

2000 • 22 citations

Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold‐exposed rats

2002 • 19 citations

Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain

2003 • 17 citations

Oxygen and Oxidative Stress Modulate the Expression of Uncoupling Protein-5 in Vitro and in Vivo

2003 • 14 citations