Immediate neuronal preconditioning by NS1619

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

‘Ischemic tolerance’ phenomenon found in the brain

1990 • 1,098 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

ATP-sensitive K+ channel in the mitochondrial inner membrane

1991 • 746 citations

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury

1993 • 694 citations

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

1993 • 629 citations

Cytoprotective Role of Ca ²⁺ - Activated K ⁺ Channels in the Cardiac Inner Mitochondrial Membrane

2002 • 478 citations

Ca2+-Activated K Channel of the BK-Type in the Inner Mitochondrial Membrane of a Human Glioma Cell Line

1999 • 296 citations

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

1993 • 265 citations

Mitochondrial Dysfunction and Glutamate Excitotoxicity Studied in Primary Neuronal Cultures

2004 • 265 citations

Activation of pro‐survival Akt and ERK1/2 signalling pathways underlie the anti‐apoptotic effects of flavanones in cortical neurons

2007 • 247 citations

Cellular titration of apoptosis with steady state concentrations of H2O2: submicromolar levels of H2O2 induce apoptosis through fenton chemistry independent of the cellular thiol state

2001 • 246 citations

Oxygen free radicals regulate NMDA receptor function via a redox modulatory site

1990 • 205 citations

Mitochondrial Ca ²⁺ -Activated K ⁺ Channels in Cardiac Myocytes

2004 • 195 citations

Adaptation of adult brain tissue to anoxia and hypoxia in vitro

1986 • 174 citations

Effects of the BK_Ca channel activator, NS1619, on rat cerebral artery smooth muscle

1996 • 168 citations

Ion channel modulation by NS 1619, the putative BK_Ca channel opener, in vascular smooth muscle

1994 • 151 citations

Reactive Oxygen Species as Mediators of Signal Transduction in Ischemic Preconditioning

2004 • 144 citations

Diazoxide induces delayed pre‐conditioning in cultured rat cortical neurons

2003 • 141 citations

Cardiac mitochondrial preconditioning by Big Ca²⁺-sensitive K⁺ channel opening requires superoxide radical generation

2005 • 132 citations

Calcium-Activated Potassium Channel Triggers Cardioprotection of Ischemic Preconditioning

2004 • 130 citations

Mitochondrial Ca²⁺-induced K⁺ influx increases respiration and enhances ROS production while maintaining membrane potential

2006 • 129 citations

Targeting mitochondrial ATP-sensitive potassium channels—a novel approach to neuroprotection

2004 • 126 citations

BK channel openers inhibit ROS production of isolated rat brain mitochondria

2008 • 119 citations

Prolonged anoxic survival due to anoxia pre-exposure: brain ATP, lactate, and pyruvate

1964 • 110 citations

Mitochondrial Potassium Channel Opener Diazoxide Preserves Neuronal-Vascular Function After Cerebral Ischemia in Newborn Pigs

1999 • 105 citations

The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain

2006 • 101 citations

Developmental expression, compartmentalization, and possible role in excitotoxicity of a putative NMDA receptor protein in cultured hippocampal neurons

1991 • 99 citations

A novel potassium channel in skeletal muscle mitochondria

2008 • 85 citations

Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells

2003 • 80 citations

Glutamate‐mediated influx of extracellular Ca²⁺ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes

2004 • 79 citations

Opening of Ca²⁺-activated K⁺ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice

2004 • 78 citations

ALTERATIONS IN LYSOSOMES (INTRACELLULAR ENZYMES) DURING SHOCK; EFFECTS OF PRECONDITIONING (TOLERANCE) AND PROTECTIVE DRUGS

1964 • 74 citations

Opening of Ca2+-activated K+ channels is involved in ischemic preconditioning in canine hearts

2004 • 68 citations

THE DEVELOPMENT OF RESISTANCE BY RATS AND GUINEA PIGS TO AMOUNTS OF TRAUMA USUALLY FATAL

1943 • 67 citations

The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning

2004 • 66 citations

The Mitochondrial K_ATP Channel Opener BMS-191095 Reduces Neuronal Damage after Transient Focal Cerebral Ischemia in Rats

2006 • 62 citations

Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels

2007 • 62 citations

The mitochondrial Ca2+-activated K+ channel activator, NS 1619 inhibits L-type Ca2+ channels in rat ventricular myocytes

2007 • 56 citations

ROS-Independent Preconditioning in Neurons via Activation of mitoK_ATP Channels by BMS-191095

2008 • 50 citations

Large-Conductance Potassium Cation Channel Opener NS1619 Inhibits Cardiac Mitochondria Respiratory Chain

2004 • 50 citations

The K+ channel openers diazoxide and NS1619 induce depolarization of mitochondria and have differential effects on cell Ca2+ in CD34+ cell line KG-1a

2003 • 47 citations

Alterations of N-methyl-D-aspartate receptor properties after chemical ischemia.

2000 • 43 citations

Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons

2006 • 39 citations

Potassium Channel Activators Protect the N -Methyl- <scp>d</scp> -Aspartate–Induced Cerebral Vascular Dilation After Combined Hypoxia and Ischemia in Piglets

1998 • 35 citations

BK channel activation by NS‐1619 is partially mediated by intracellular Ca²⁺ release in smooth muscle cells of porcine coronary artery

2001 • 33 citations

ANESTHETIC PRECONDITIONING CONFERS ACUTE CARDIOPROTECTION VIA UP-REGULATION OF MANGANESE SUPEROXIDE DISMUTASE AND PRESERVATION OF MITOCHONDRIAL RESPIRATORY ENZYME ACTIVITY

2008 • 23 citations

Neuronal preconditioning with the antianginal drug, bepridil

2007 • 16 citations