Mitochondria in Neuroplasticity and Neurological Disorders

Staging of brain pathology related to sporadic Parkinson’s disease

2002 • 9,557 citations

α-Synuclein Locus Triplication Causes Parkinson's Disease

2003 • 4,187 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

1997 • 3,163 citations

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

2005 • 3,020 citations

Pathways towards and away from Alzheimer's disease

2004 • 2,936 citations

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

2008 • 2,514 citations

Huntington's disease

2007 • 2,393 citations

A Century of Alzheimer's Disease

2006 • 1,966 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses

2004 • 1,400 citations

ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors

2006 • 1,371 citations

Mitochondrial Abnormalities in Alzheimer's Disease

2001 • 1,319 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

2004 • 1,232 citations

The axonal transport of mitochondria

2012 • 1,171 citations

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

2003 • 1,156 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

2004 • 1,091 citations

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

2004 • 1,063 citations

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

2006 • 1,035 citations

The apoptosome: signalling platform of cell death

2007 • 1,018 citations

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

2002 • 1,009 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

2008 • 979 citations

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

2004 • 959 citations

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

2006 • 958 citations

Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

1998 • 874 citations

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

2008 • 853 citations

The PINK1/Parkin pathway regulates mitochondrial morphology

2008 • 845 citations

Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

2004 • 843 citations

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

2008 • 826 citations

Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions

2005 • 797 citations

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

2005 • 793 citations

Ancient Invasions: From Endosymbionts to Organelles

2004 • 770 citations

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

2006 • 765 citations

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

2007 • 734 citations

The axonal transport of mitochondria

2005 • 727 citations

Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1

1998 • 706 citations

Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled

2006 • 703 citations

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

2006 • 703 citations

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

2000 • 694 citations

Superoxide Flashes in Single Mitochondria

2008 • 689 citations

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

2003 • 680 citations

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

1999 • 680 citations

Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

2006 • 648 citations

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons

2006 • 640 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

2008 • 623 citations

Axonal Transport of Mitochondria to Synapses Depends on Milton, a Novel Drosophila Protein

2002 • 616 citations

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1997 • 593 citations

PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

2007 • 584 citations

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

2008 • 566 citations

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

2006 • 545 citations

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

2008 • 524 citations

Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

2007 • 511 citations

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- <scp>l</scp> -carnitine and/or R -α-lipoic acid

2002 • 510 citations

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

2003 • 506 citations

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

2004 • 498 citations

Axonal mitochondrial transport and potential are correlated

2004 • 492 citations

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

2001 • 490 citations

Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria

2004 • 490 citations

Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis

2004 • 482 citations

p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease

2005 • 477 citations

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

2003 • 469 citations

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

2007 • 467 citations

A Hundred Years of Alzheimer's Disease Research

2006 • 461 citations

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

2000 • 459 citations

Mitochondrial Involvement in Post-Tetanic Potentiation of Synaptic Transmission

1997 • 455 citations

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

2005 • 418 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

2007 • 410 citations

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

2008 • 402 citations

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

2007 • 401 citations

PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review

2000 • 399 citations

Presynaptic Mitochondrial Calcium Sequestration Influences Transmission at Mammalian Central Synapses

2002 • 392 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

2003 • 388 citations

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

2004 • 383 citations

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1998 • 382 citations

Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS

2006 • 382 citations

p53 in neuronal apoptosis

2005 • 374 citations

Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death

1998 • 372 citations

Mitochondrial dynamics and division in budding yeast

2002 • 368 citations

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

1997 • 355 citations

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism

1999 • 354 citations

3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease

2005 • 352 citations

Evidence for Synaptic Apoptosis

1998 • 342 citations

Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses

2006 • 338 citations

Hippocampal hypometabolism predicts cognitive decline from normal aging

2007 • 336 citations

Moving Mitochondria: Establishing Distribution of an Essential Organelle

2007 • 323 citations

Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations

2007 • 323 citations

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1993 • 318 citations

MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease

1991 • 302 citations

Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain

2003 • 301 citations

Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

2003 • 300 citations

Nerve Growth Factor Signaling Regulates Motility and Docking of Axonal Mitochondria

2004 • 297 citations

Mitochondrial involvement in psychiatric disorders

2008 • 293 citations

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

2006 • 291 citations

Mitochondrial Dysfunction in SOD1^G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

2008 • 291 citations

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis

2002 • 285 citations

Energy metabolism in mammalian brain during development

2004 • 285 citations

Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death

2004 • 278 citations

Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis

2005 • 273 citations

A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin

2004 • 270 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1997 • 266 citations

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria

2008 • 264 citations

Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients

2002 • 262 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1998 • 260 citations

ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis

1999 • 254 citations

Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory

2006 • 253 citations

Endophilin B1 is required for the maintenance of mitochondrial morphology

2004 • 253 citations

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

2001 • 252 citations

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials

2006 • 250 citations

Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria

2004 • 248 citations

Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice

2006 • 248 citations

Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory

2006 • 247 citations

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

2004 • 245 citations

Genetics of familial and sporadic amyotrophic lateral sclerosis

2006 • 244 citations

Similar Patterns of Mitochondrial Vulnerability and Rescue Induced by Genetic Modification of α-Synuclein, Parkin, and DJ-1 in Caenorhabditis elegans

2005 • 244 citations

Mitochondrial Ca2+ as a key regulator of cell life and death

2007 • 237 citations

Bioenergetic approaches for neuroprotection in Parkinson's disease

2003 • 233 citations

The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells

2005 • 219 citations

Activation of Mitochondrial ATP-Dependent Potassium Channels Protects Neurons against Ischemia-Induced Death by a Mechanism Involving Suppression of Bax Translocation and Cytochrome c Release

2002 • 214 citations

Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction

2005 • 211 citations

Organelle motility and metabolism in axons vs dendrites of cultured hippocampal neurons

1996 • 202 citations

Review of the Literature on Major Mental Disorders in Adult Patients With Mitochondrial Diseases

2005 • 199 citations

Phosphorylation of Neurofilaments Is Altered in Amyotrophic Lateral Sclerosis

1988 • 198 citations

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis

2006 • 186 citations

Mitochondrial UCP4 Mediates an Adaptive Shift in Energy Metabolism and Increases the Resistance of Neurons to Metabolic and Oxidative Stress

2006 • 176 citations

Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

2007 • 174 citations

Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS

2005 • 174 citations

Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

2007 • 169 citations

Mitochondrial associated metabolic proteins are selectively oxidized in A30P α-synuclein transgenic mice—a model of familial Parkinson's disease

2005 • 167 citations

Mitochondrial Regulation of Synaptic Plasticity in the Hippocampus

2003 • 166 citations

Induction of neuronal death by α‐synuclein

2000 • 163 citations

Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathway

2003 • 159 citations

Mitochondrial Translocation of p53 Mediates Release of Cytochromecand Hippocampal CA1 Neuronal Death after Transient Global Cerebral Ischemia in Rats

2006 • 159 citations

Apoptosis in amyotrophic lateral sclerosis: a review of the evidence

2001 • 159 citations

Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology

2007 • 158 citations

Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis.

1995 • 153 citations

NAD(P)H Fluorescence Imaging of Postsynaptic Neuronal Activation in Murine Hippocampal Slices

2003 • 152 citations

Response of Mitochondrial Traffic to Axon Determination and Differential Branch Growth

2003 • 147 citations

Cytosolic Ca²⁺Changes duringIn VitroIschemia in Rat Hippocampal Slices: Major Roles for Glutamate and Na⁺-Dependent Ca²⁺Release from Mitochondria

1999 • 146 citations

Increased Autophagic Degradation of Mitochondria in Alzheimer Disease

2007 • 146 citations

Mitochondrial fission and fusion dynamics: the long and short of it

2008 • 141 citations

Caspase-Dependent and -Independent Neuronal Death: Two Distinct Pathways to Neuronal Injury

2005 • 139 citations

The Chemistry of Peroxynitrite: Implications for Biological Activity

2008 • 139 citations

Apoptosis and necrosis in health and disease: Role of mitochondria

2003 • 137 citations

Mutant Huntingtin Expression Induces Mitochondrial Calcium Handling Defects in Clonal Striatal Cells

2006 • 136 citations

Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences

2007 • 136 citations

BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II

2004 • 134 citations

4-Hydroxynonenal, a Product of Lipid Peroxidation, Damages Cholinergic Neurons and Impairs Visuospatial Memory in Rats

1998 • 133 citations

Caspase-Mediated Degradation of AMPA Receptor Subunits: A Mechanism for Preventing Excitotoxic Necrosis and Ensuring Apoptosis

2000 • 133 citations

The Identity and Regulation of the Mitochondrial Permeability Transition Pore

2008 • 133 citations

Strain-Dependent Neurodevelopmental Abnormalities in Caspase-3-Deficient Mice

2002 • 130 citations

Hormesis/preconditioning mechanisms, the nervous system and aging

2006 • 129 citations

Brain-Derived Neurotrophic Factor Stimulates Energy Metabolism in Developing Cortical Neurons

2003 • 127 citations

The mitochondrial uncoupler 2,4‐dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia

2005 • 126 citations

Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture

2006 • 126 citations

Differential Effects of Mitochondrial Heat Shock Protein 60 and Related Molecular Chaperones to Prevent Intracellular β-Amyloid-induced Inhibition of Complex IV and Limit Apoptosis

2006 • 124 citations

Changes in Mitochondrial Function Resulting from Synaptic Activity in the Rat Hippocampal Slice

1998 • 121 citations

Dynamic Role of Postsynaptic Caspase-3 and BIRC4 in Zebra Finch Song-Response Habituation

2006 • 120 citations

Mitochondrial Sensitivity and Altered Calcium Handling Underlie Enhanced NMDA-Induced Apoptosis in YAC128 Model of Huntington's Disease

2007 • 119 citations

Loss ofALS2Function Is Insufficient to Trigger Motor Neuron Degeneration in Knock-Out Mice But Predisposes Neurons to Oxidative Stress

2005 • 115 citations

Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery

2007 • 109 citations

Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells

2003 • 109 citations

Intrathecal cyclosporin prolongs survival of late-stage ALS mice

2001 • 108 citations

Mitochondrial Uncoupling Protein-4 Regulates Calcium Homeostasis and Sensitivity to Store Depletion-induced Apoptosis in Neural Cells

2006 • 108 citations

Mitochondrial Dysfunction as the Molecular Basis of Bipolar Disorder

2007 • 107 citations

Novel p53 Inactivators with Neuroprotective Action: Syntheses and Pharmacological Evaluation of 2-Imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-Imino-2,3,4,5,6,7-hexahydrobenzoxazole Derivatives

2002 • 103 citations

Participation of the mitochondrial genome in the differentiation of neuroblastoma cells

1992 • 98 citations

Bax, Reactive Oxygen, and CytochromecRelease in Neuronal Apoptosis

2003 • 98 citations

Evidence for mitochondrial control of neuronal polarity

1999 • 95 citations

Prostate Apoptosis Response‐4 Production in Synaptic Compartments Following Apoptotic and Excitotoxic Insults

1999 • 94 citations

Transient Spine Expansion and Learning-Induced Plasticity in Layer 1 Primary Motor Cortex

2008 • 94 citations

β-Amyloid Precursor Protein Is a Direct Cleavage Target of HtrA2 Serine Protease

2006 • 93 citations

Stroke: Molecular Mechanisms and Potential Targets for Treatment

2003 • 91 citations

Paroxetine retards disease onset and progression in Huntingtin mutant mice

2004 • 91 citations

The ultrastructure of intramuscular nerves in amyotrophic lateral sclerosis

1981 • 87 citations

Ischemic preconditioning blocks BAD translocation, Bcl-x _L cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

2008 • 87 citations

Genetic findings in Parkinson’s disease and translation into treatment: a leading role for mitochondria?

2007 • 84 citations

Direct Cleavage of AMPA Receptor Subunit GluR1 and Suppression of AMPA Currents by Caspase-3

2002 • 68 citations

Caspase activity is essential for long‐term potentiation

2003 • 67 citations

Mitochondrial Morphogenesis, Dendrite Development, and Synapse Formation in Cerebellum Require both Bcl-w and the Glutamate Receptor δ2

2008 • 66 citations

Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines

2005 • 65 citations

Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria

2006 • 57 citations

Putamen Mitochondrial Energy Metabolism Is Highly Correlated to Emotional and Intellectual Impairment in Schizophrenics

2000 • 56 citations

Nortriptyline delays disease onset in models of chronic neurodegeneration

2007 • 54 citations

Pancortin-2 Interacts with WAVE1 and Bcl-xL in a Mitochondria-Associated Protein Complex That Mediates Ischemic Neuronal Death

2007 • 50 citations

Evidence that caspase‐1 is a negative regulator of AMPA receptor‐mediated long‐term potentiation at hippocampal synapses

2006 • 49 citations

Neurotoxic Calcium Transfer from Endoplasmic Reticulum to Mitochondria Is Regulated by Cyclin-Dependent Kinase 5-Dependent Phosphorylation of Tau

2005 • 48 citations

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

2008 • 47 citations

Organization of mitochondria in olfactory bulb granule cell dendritic spines

1991 • 46 citations

Protective Effects of NIM811 in Transient Focal Cerebral Ischemia Suggest Involvement of the Mitochondrial Permeability Transition

2007 • 43 citations

Depressive disorder due to mitochondrial transfer RNALeu(UUR) mutation

1997 • 41 citations

Detrimental deletions: mitochondria, aging and Parkinson's disease

2006 • 36 citations

Bcl-X_L/Bax Proteins Direct the Fate of Embryonic Cortical Precursor Cells

2007 • 36 citations

Necrotic death of neurons following an excitotoxic insult is prevented by a peptide inhibitor of c‐jun N‐terminal kinase

2007 • 34 citations

Dependence of permeability transition pore opening and cytochrome C release from mitochondria on mitochondria energetic status.

2001 • 31 citations

Mitochondrial porin required for ischemia-induced mitochondrial dysfunction and neuronal damage

2000 • 28 citations

Modifications of microtubule proteins in ALS nerve precede detectable histologic and ultrastructural changes

1988 • 19 citations

Calpain Activation and Not Oxidative Damage Mediatesl-2-Chloropropionic Acid-Induced Cerebellar Granule Cell Necrosis

1997 • 14 citations

Diagnostic criteria and outcome measurement of amyotrophic lateral sclerosis.

2002 • 8 citations