Hypoxia‐inducible factor 1: a new hope to counteract neurodegeneration?

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

2006 • 5,824 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1

1999 • 1,882 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

2000 • 1,769 citations

Iron, brain ageing and neurodegenerative disorders

2004 • 1,737 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

2005 • 1,425 citations

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

2001 • 1,418 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial

2002 • 1,038 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

2002 • 1,009 citations

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

2001 • 1,009 citations

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

2003 • 963 citations

In vivo evidence that erythropoietin protects neurons from ischemic damage

1998 • 931 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

Signal transduction to hypoxia-inducible factor 1

2002 • 843 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1997 • 775 citations

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

2000 • 754 citations

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1988 • 738 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

2005 • 717 citations

A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice

1999 • 716 citations

Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

2002 • 698 citations

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

2001 • 688 citations

O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

2004 • 684 citations

Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia

2000 • 676 citations

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1999 • 645 citations

Hypoxia-Induced Vascular Endothelial Growth Factor Expression Precedes Neovascularization after Cerebral Ischemia

2000 • 641 citations

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

2000 • 617 citations

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

2003 • 613 citations

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

2005 • 597 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

2007 • 542 citations

HIF1 and oxygen sensing in the brain

2004 • 539 citations

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein

2001 • 518 citations

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1997 • 514 citations

Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease

2003 • 512 citations

Suppression of tumor growth through disruption of hypoxia-inducible transcription

2000 • 501 citations

The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function

2004 • 459 citations

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

2000 • 422 citations

Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.

1996 • 420 citations

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells

2007 • 420 citations

Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

2004 • 417 citations

Induction of hypoxia‐inducible factor‐1 (HIF‐1) and its target genes following focal ischaemia in rat brain

1999 • 412 citations

Mitochondrial complex III regulates hypoxic activation of HIF

2008 • 404 citations

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1999 • 387 citations

Redox-active iron mediates amyloid-β toxicity

2001 • 376 citations

Series Introduction: Neurodegeneration: What is it and where are we?

2003 • 371 citations

Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α

2000 • 371 citations

Environmental-induced oxidative stress in neurodegenerative disorders and aging

2008 • 370 citations

Transferrin Receptor Induction by Hypoxia

1999 • 352 citations

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

2006 • 347 citations

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

2000 • 341 citations

Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1 Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia

2007 • 336 citations

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

2008 • 334 citations

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

1998 • 333 citations

Intraventricular Brain-Derived Neurotrophic Factor Reduces Infarct Size after Focal Cerebral Ischemia in Rats

1997 • 326 citations

Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21^waf1/cip1, and Erythropoietin

1999 • 319 citations

Series Introduction: Neurodegeneration: What is it and where are we?

2003 • 316 citations

Intravenous Brain-Derived Neurotrophic Factor Reduces Infarct Size and Counterregulates Bax and Bcl-2 Expression After Temporary Focal Cerebral Ischemia

2000 • 316 citations

HIF hydroxylation and the mammalian oxygen-sensing pathway

2003 • 313 citations

Erythropoietin Prevents Place Navigation Disability and Cortical Infarction in Rats with Permanent Occlusion of the Middle Cerebral Artery

1998 • 304 citations

The possible role of iron in the etiopathology of parkinson's disease

1993 • 303 citations

The Iron Chelator Desferrioxamine (Desferal) Retards 6‐Hydroxydopamine‐Induced Degeneration of Nigrostriatal Dopamine Neurons

1991 • 297 citations

Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1

2000 • 294 citations

HIF hydroxylation and the mammalian oxygen-sensing pathway

2003 • 288 citations

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

2005 • 282 citations

Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency

2000 • 275 citations

Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia

2000 • 258 citations

The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide

2003 • 245 citations

Hypoxic preconditioning protects against ischemic brain injury

2004 • 239 citations

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia

1998 • 224 citations

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

2002 • 211 citations

The Role of Mitochondria in the Regulation of Hypoxia-inducible Factor 1 Expression during Hypoxia

2000 • 208 citations

Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.

1994 • 207 citations

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

2009 • 199 citations

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

2001 • 197 citations

Clioquinol down-regulates mutant huntingtin expressionin vitroand mitigates pathology in a Huntington's disease mouse model

2005 • 191 citations

Desferrioxamine Induces Delayed Tolerance against Cerebral Ischemiain Vivoandin Vitro

2002 • 187 citations

An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease

2009 • 184 citations

Neuroprotection by Hypoxic Preconditioning Involves Oxidative Stress-Mediated Expression of Hypoxia-Inducible Factor and Erythropoietin

2005 • 176 citations

Hypoxic Induction of Prolyl 4-Hydroxylase α(I) in Cultured Cells

2000 • 173 citations

Causes and Consequences of Disturbances of Cerebral Glucose Metabolism in Sporadic Alzheimer Disease: Therapeutic Implications

2004 • 166 citations

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

1997 • 162 citations

Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction

2007 • 149 citations

Hypoxia-induced Nucleophosmin Protects Cell Death through Inhibition of p53

2004 • 148 citations

Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase.

2002 • 147 citations

Iron: A Pathological Mediator of Alzheimer Disease?

2002 • 147 citations

The key role of mitochondria in Alzheimer's disease

2006 • 145 citations

Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway

2001 • 143 citations

Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson Diseases

2007 • 138 citations

Metal ions and oxidative protein modification in neurological disease.

2005 • 134 citations

Evidence for Neuroprotective Effects of Endogenous Brain-Derived Neurotrophic Factor after Global Forebrain Ischemia in Rats

1999 • 128 citations

A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF‐1α

2005 • 126 citations

Relationship between oxidative stress and HIF-1α mRNA during sustained hypoxia in humans

2008 • 126 citations

Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene

1999 • 124 citations

Structure of Human FIH-1 Reveals a Unique Active Site Pocket and Interaction Sites for HIF-1 and von Hippel-Lindau

2003 • 121 citations

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat

2006 • 116 citations

Mechanism of HIF‐1α‐dependent suppression of hypoxia‐induced apoptosis in squamous cell carcinoma cells

2005 • 113 citations

Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential‐Display PCR

1996 • 113 citations

Regulation of HIF by the von Hippel‐Lindau Tumour Suppressor: Implications for Cellular Oxygen Sensing

2001 • 110 citations

Concurrent alterations of O‐GlcNAcylation and phosphorylation of tau in mouse brains during fasting

2006 • 110 citations

Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons

1998 • 110 citations

A role for hypoxia-inducible factor-1α in desferoxamine neuroprotection

2005 • 106 citations

Hypoxia-inducible factor 1α and erythropoietin upregulation with deferoxamine salvage after neonatal stroke

2005 • 105 citations

Hypoxia-inducible factor in brain

2001 • 103 citations

Preconditioning-induced neuroprotection is mediated by reactive oxygen species

2000 • 103 citations

Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity

2009 • 99 citations

HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport

2009 • 87 citations

Generation of hydrogen peroxide during brief oxygen‐glucose deprivation induces preconditioning neuronal protection in primary cultured neurons

2005 • 86 citations

The induction of HIF‐1 reduces astrocyte activation by amyloid beta peptide

2009 • 85 citations

Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia

2008 • 84 citations

Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1

2004 • 81 citations

Cytoprotective Efficacy and Mechanisms of the Liposoluble Iron Chelator 2,2′-Dipyridyl in the Rat Photothrombotic Ischemic Stroke Model

2004 • 73 citations

Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment

2009 • 73 citations

Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1α and erythropoietin

2008 • 72 citations

Huntington's Disease and Dentatorubral‐Pallidoluysian Atrophy: Proteins, Pathogenesis and Pathology

1997 • 62 citations

Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice

2009 • 61 citations

Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons

2008 • 61 citations

Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells.

2004 • 60 citations

Reversion of age-related recognition memory impairment by iron chelation in rats

2007 • 57 citations

Neurodegenerative Pathways in Parkinsons Disease: Therapeutic Strategies

2005 • 54 citations

Induction of hypoxia inducible factor‐1 attenuates metabolic insults induced by 3‐nitropropionic acid in rat C6 glioma cells

2005 • 53 citations

Targeting Hypoxia-Inducible Factor (HIF) as a Therapeutic Strategy for CNS Disorders

2005 • 52 citations

Brain and brawn

2006 • 52 citations

Prolyl 4-hydroxylase activity-responsive transcription factors: From hydroxylation to gene expression and neuroprotection

2007 • 46 citations

The effect of 2-methoxyestradiol, a HIF-1αinhibitor, in global cerebral ischemia in rats

2008 • 40 citations

Cellular and molecular basis of b-amyloid precursor protein metabolism (Y2K update)

2000 • 38 citations

Cellular and molecular basis of beta-amyloid precursor protein metabolism

1998 • 30 citations

HIF‐1 alpha is an essential effector for purine nucleoside‐mediated neuroprotection against hypoxia in PC12 cells and primary cerebellar granule neurons

2008 • 22 citations

The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease

2006 • 21 citations

Effect of diets with different magnesium content in ischemic stroke rats

2004 • 16 citations

Association of the IVS9-675C > A polymorphism of the HIF-1α gene with acute ischemic stroke in the Moscow population

2006 • 5 citations