Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: role of tumour necrosis factor-α?

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1997 • 1,647 citations

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

1997 • 1,067 citations

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2000 • 770 citations

Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin

1997 • 755 citations

UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue

1997 • 728 citations

Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

1997 • 488 citations

UCP4, a novel brain‐specific mitochondrial protein that reduces membrane potential in mammalian cells

1999 • 373 citations

Initiation of acute phase response and synthesis of cytokines

1996 • 338 citations

BMCP1, a Novel Mitochondrial Carrier with High Expression in the Central Nervous System of Humans and Rodents, and Respiration Uncoupling Activity in Recombinant Yeast

1998 • 313 citations

Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice

1998 • 309 citations

Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?

1998 • 308 citations

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians

1998 • 290 citations

Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature

1998 • 282 citations

Linkage Between Markers in the Vicinity of the Uncoupling Protein 2 Gene and Resting Metabolic Rate in Humans

1997 • 227 citations

Tissue‐dependent upregulation of rat uncoupling protein‐2 expression in response to fasting or cold

1997 • 221 citations

Cloning of rat uncoupling protein‐3 and uncoupling protein‐2 cDNAs: their gene expression in rats fed high‐fat diet

1997 • 189 citations

Regulation of the Third Member of the Uncoupling Protein Family, UCP3, by Cold and Thyroid Hormone

1997 • 184 citations

The metabolic basis of cancer cachexia

1997 • 182 citations

The Human Uncoupling Protein-3 Gene

1997 • 174 citations

Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating rat liver

1999 • 155 citations

Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians.

1999 • 132 citations

Distribution of the uncoupling protein 2 mRNA in the mouse brain

1998 • 104 citations

Expression of mRNAs encoding uncoupling proteins in human skeletal muscle: effects of obesity and diabetes.

1998 • 101 citations

Bacterial Lipopolysaccharide Induces Uncoupling Protein-2 Expression in Hepatocytes by a Tumor Necrosis Factor-α-Dependent Mechanism

1998 • 98 citations

In the rat, tumor necrosis factor α administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine‐induced thermogenesis?

1998 • 97 citations

Exacerbated febrile responses to LPS, but not turpentine, in TNF double receptor-knockout mice

1997 • 90 citations

The mitochondrial uncoupling protein-2: current status

1999 • 85 citations

Induction of UCP2 Gene Expression by LPS: A Potential Mechanism for Increased Thermogenesis during Infection

1998 • 81 citations

Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics

2000 • 80 citations

Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model

1998 • 74 citations

Central effects of TNF α on thermogenesis and fever in the rat

1988 • 66 citations

Differential regulation of uncoupling protein‐1, ‐2 and ‐3 gene expression by sympathetic innervation in brown adipose tissue of thermoneutral or cold‐exposed rats

1999 • 57 citations

Overexpression of muscle uncoupling protein 2 content in human obesity associates with reduced skeletal muscle lipid utilization

1998 • 57 citations

Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat

1987 • 49 citations

Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa

1999 • 49 citations

Differential Regulation of Uncoupling Protein-2 and Uncoupling Protein-3 Gene Expression in Brown Adipose Tissue during Development and Cold Exposure

1998 • 47 citations

Chapter 9 Brain eicosanoids and LPS fever: species and age differences

1998 • 47 citations

Uncoupling Protein-2 Messenger Ribonucleic Acid Expression During Very-Low-Calorie Diet in Obese Premenopausal Women

1998 • 43 citations

Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats

1993 • 40 citations

Recombinant human tumor necrosis factor causes long-lasting and prostaglandin-mediated fever, with little tolerance, in rabbits.

1988 • 38 citations

Difference in induction of uncoupling protein genes in adipose tissues between young and old rats during cold exposure

1999 • 32 citations

Selective Enhancement of LPS-Induced Serum TNF-α Production by Carrageenan Pretreatment in Mice

1998 • 25 citations

Induction of rat uncoupling protein‐2 gene treated with tumour necrosis factor alpha in vivo

1999 • 24 citations

Mechanisms of cachexia induced by T-cell leukemia in the rat

1996 • 22 citations

Thermoregulatory Heat Production in the Brain

1959 • 21 citations