Neuroprotective Effects of Ischemic Preconditioning in Brain Mitochondria Following Cerebral Ischemia

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Oxidative stress and apoptosis

2000 • 1,188 citations

‘Ischemic tolerance’ phenomenon found in the brain

1990 • 1,098 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis

1998 • 702 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

Free radicals in cerebral ischemia.

1978 • 589 citations

Mitochondrial PKCε and MAPK Form Signaling Modules in the Murine Heart

2002 • 417 citations

Mitochondria in Neurodegeneration: Acute Ischemia and Chronic Neurodegenerative Diseases

1999 • 354 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

2003 • 296 citations

Ischemic Delayed Neuronal Death

1995 • 285 citations

Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitro

1985 • 278 citations

Oxygen Radicals in Focal Cerebral Ischemia

1994 • 263 citations

Ischemic preconditioning in rats: role of mitochondrial K_ATPchannel in preservation of mitochondrial function

2000 • 228 citations

Oxygen radicals in CNS damage

1989 • 226 citations

Rapid Preconditioning Protects Rats against Ischemic Neuronal Damage after 3 but Not 7 Days of Reperfusion following Global Cerebral Ischemia

1997 • 225 citations

Free radicals in CNS injury.

1993 • 221 citations

εPKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice

2003 • 211 citations

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

1997 • 185 citations

Mitochondrial permeability transition in acute neurodegeneration

2002 • 180 citations

Adaptation of adult brain tissue to anoxia and hypoxia in vitro

1986 • 174 citations

Anoxic preconditioning in hippocampal slices: role of adenosine

1996 • 172 citations

Altered Mitochondrial Respiration in Selectively Vulnerable Brain Subregions Following Transient Forebrain Ischemia in the Rat

1987 • 159 citations

Focal Ischemic Preconditioning Induces Rapid Tolerance to Middle Cerebral Artery Occlusion in Mice

1999 • 149 citations

Rapid preconditioning neuroprotection following anoxia in hippocampal slices: Role of the k+ATP channel and protein kinase C

1999 • 127 citations

Columnar Alterations of NADH Fluorescence during Hypoxia-Ischemia in Immature Rat Brain

1982 • 123 citations

Cytochrome C Is Released from Mitochondria Into the Cytosol after Cerebral Anoxia or Ischemia

1999 • 122 citations

Oxygen, antioxidants and brain dysfunction

1993 • 122 citations

Rapid Cerebral Ischemic Preconditioning in Mice Deficient in Endothelial and Neuronal Nitric Oxide Synthases

2003 • 118 citations

Ischemic Preconditioning Preserves Mitochondrial Function after Global Cerebral Ischemia in Rat Hippocampus

2001 • 107 citations

Hypoxia and oxygen toxicity.

1979 • 103 citations

Nitric oxide is involved in anoxic preconditioning neuroprotection in rat hippocampal slices

1999 • 96 citations

Ischemic Injury in the Brain Role of Oxygen Radical‐Mediated Processesa

1989 • 88 citations

Rapid Tolerance to Focal Cerebral Ischemia in Rats is Attenuated by Adenosine A₁ Receptor Antagonist

2002 • 83 citations

Diazepam Promotes ATP Recovery and Prevents Cytochrome c Release in Hippocampal Slices After In Vitro Ischemia

2000 • 82 citations

The mechanism of neuronal resistance and adaptation to hypoxia

1987 • 76 citations

Ischemic injury to rat forebrain mitochondria and cellular calcium homeostasis

1992 • 75 citations

NADH Fluorescence and Regional Energy Metabolites during Focal Ischemia and Reperfusion of Rat Brain

1991 • 72 citations

Antioxidants, mitochondrial hyperoxidation and electrical recovery after anoxia in hippocampal slices

1997 • 71 citations

Differing Neurochemical and Morphological Sequelae of Global Ischemia: Comparison of Single‐ and Multiple‐Insult Paradigms

1992 • 68 citations

Preconditioning preserves mitochondrial function and glycolytic flux during an early period of reperfusion in perfused rat hearts

1997 • 66 citations

Mitochondrial Hyperoxidation Signals Residual Intracellular Dysfunction after Global Ischemia in Rat Neocortex

1995 • 61 citations

Induction of tolerance to ischemia: Alterations in second-messenger systems in the gerbil hippocampus

1992 • 61 citations

Anoxia‐Induced Gene Expression in Turtle Heart

1996 • 60 citations

The influence of the time period between preconditioning ischemia and prolonged ischemia on myocardial protection.

1993 • 46 citations

Effect of Peroxide, Sodium, and Calcium on Brain Mitochondrial Respiration In Vitro: Potential Role in Cerebral Ischemia and Reperfusion

1990 • 45 citations

Preconditioning of primary rat neuronal cultures against ischemic injury: characterization of the `time window of protection'

1996 • 44 citations

Calcium Influx from the Extracellular Space Promotes NADH Hyperoxidation and Electrical Dysfunction after Anoxia in Hippocampal Slices

1998 • 44 citations

Calcium and increase excitability promote tolerance against anoxia in hippocampal slices

1999 • 43 citations

MK-801 (Dizocilpine) Protects the Brain from Repeated Normothermic Global Ischemic Insults in the Rat

1993 • 37 citations

Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning.

2001 • 35 citations

The effect of rapid preconditioning on the microglial, astrocytic and neuronal consequences of global cerebral ischemia

1999 • 34 citations

The biochemical basis of ischemic brain lesions.

1991 • 33 citations

Effect of the first window of ischemic preconditioning on mitochondrial dysfunction following global cerebral ischemia

2002 • 19 citations

Global myocardial ischemia protects the myocardium from subsequent regional ischemia.

1993 • 19 citations

Changes in non-synaptosomal and synaptosomal mitochondrial membrane-linked enzymatic activities after transient cerebral ischemia

1994 • 17 citations

Mitochondrial hyperoxidation after cerebral anoxia/ischemia. Epiphenomenon or precursor to residual damage?

1997 • 9 citations