Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Neurological Deficit and Extent of Neuronal Necrosis Attributable to Middle Cerebral Artery Occlusion in Rats

1995 • 1,381 citations

Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture

1996 • 772 citations

The Late Phase of Preconditioning

2000 • 753 citations

The Mitochondrial K Channel as a Receptor for Potassium Channel Openers

1996 • 447 citations

Longer Duration of Cardiopulmonary Bypass Is Associated With Greater Numbers of Cerebral Microemboli

2000 • 237 citations

K channels and preconditioning: A re-examination of the role of mitochondrial K channels and an overview of alternative mechanisms

2005 • 218 citations

Activation of Mitochondrial ATP-Dependent Potassium Channels Protects Neurons against Ischemia-Induced Death by a Mechanism Involving Suppression of Bax Translocation and Cytochrome c Release

2002 • 214 citations

Inhalational Anesthetics as Neuroprotectants or Chemical Preconditioning Agents in Ischemic Brain

2006 • 194 citations

Preconditioning with Isoflurane Produces Dose-Dependent Neuroprotection via Activation of Adenosine Triphosphate-Regulated Potassium Channels After Focal Cerebral Ischemia in Rats

2003 • 179 citations

Activation of Mitochondrial K _ATP Channel Elicits Late Preconditioning Against Myocardial Infarction via Protein Kinase C Signaling Pathway

1999 • 152 citations

Diazoxide induces delayed pre‐conditioning in cultured rat cortical neurons

2003 • 141 citations

Preconditioning with Isoflurane Produces Dose-Dependent Neuroprotection via Activation of Adenosine Triphosphate-Regulated Potassium Channels After Focal Cerebral Ischemia in Rats

2003 • 135 citations

Mitochondrial ATP-Sensitive Potassium Channel Activation Protects Cerebellar Granule Neurons From Apoptosis Induced by Oxidative Stress

2003 • 124 citations

MitoK_ATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat

2002 • 120 citations

Mitochondrial Adenosine Triphosphate–regulated Potassium Channel Opening Acts as a Trigger for Isoflurane-induced Preconditioning by Generating Reactive Oxygen Species

2003 • 115 citations

Mitochondrial Potassium Channel Opener Diazoxide Preserves Neuronal-Vascular Function After Cerebral Ischemia in Newborn Pigs

1999 • 105 citations

Mitochondrial KATP channels in preconditioning

2003 • 94 citations

Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection31The Thoracic Surgery Directors Association (TSDA) Resident Research Award, sponsored by Medtronic, Inc, was established in 1990 to encourage resident research in cardiothoracic surgery. Abstracts submitted to The Society of Thoracic Surgeons (STS) Program Committee representing research performed by residents were forwarded to the TSDA to be considered for this award. The abstracts were reviewed by …

2001 • 90 citations

Cardiac protection by mitoK_ATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning

2006 • 77 citations

Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia

1999 • 71 citations

Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation

2004 • 67 citations

Diazoxide preconditioning attenuates global cerebral ischemia-induced blood–brain barrier permeability

2005 • 66 citations

The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore

2006 • 66 citations

Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats

2002 • 57 citations

Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning

2004 • 49 citations

Diazoxide pretreatment induces delayed preconditioning in astrocytes against oxygen glucose deprivation and hydrogen peroxide‐induced toxicity

2003 • 47 citations

KATP opener-induced delayed cardioprotection: involvement of sarcolemmal and mitochondrial KATP channels, free radicals and MEK1/2

2003 • 41 citations

ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus

2002 • 38 citations

Late preconditioning with isoflurane in cultured rat cortical neurones

2005 • 37 citations

MitoKATP-Channel Opener Protects against Neuronal Death in Rat Venous Ischemia

2005 • 31 citations

Reactive oxygen species mediate the neuroprotection conferred by a mitochondrial ATP-sensitive potassium channel opener during ischemia in the rat hippocampal slice

2005 • 30 citations

Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets

2005 • 29 citations

Protective effect of a new nonpeptidyl mimetic of SOD, M40401, against focal cerebral ischemia in the rat

2003 • 27 citations

Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain

2004 • 24 citations

Adenosine and a Nitric Oxide Donor Enhances Cardioprotection by Preconditioning with Isoflurane through Mitochondrial Adenosine Triphosphate-sensitive K+Channel-dependent and -independent Mechanisms

2004 • 22 citations

Cortical spreading depression (CSD)-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels

2005 • 18 citations

Metabolism and disposition of diazoxide. A mini-review.

1975 • 17 citations

Cardioprotective Effects Of Nicorandil In Rabbits Anaesthetized With Halothane: Potentiation Of Ischaemic Preconditioning Via K_ATP Channels

2000 • 14 citations