Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: Mitochondrial targeted preconditioning

Calcium: still center-stage in hypoxic-ischemic neuronal death

1995 • 921 citations

Calcium in Ischemic Cell Death

1998 • 818 citations

Cerebral preconditioning and ischaemic tolerance

2006 • 740 citations

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels*

1999 • 650 citations

Genetic Analysis of Italian Patients with Congenital Hyperinsulinism of Infancy

2013 • 540 citations

Cytoprotective Role of Ca ²⁺ - Activated K ⁺ Channels in the Cardiac Inner Mitochondrial Membrane

2002 • 478 citations

Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems

2005 • 453 citations

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells

2007 • 420 citations

Roles of Mitochondria in Health and Disease

2004 • 414 citations

K_ATP channel‐independent targets of diazoxide and 5‐hydroxydecanoate in the heart

2002 • 323 citations

Large-conductance, calcium-activated potassium channels: Structural and functional implications

2005 • 317 citations

Mitochondrial Sources of H ₂ O ₂ Generation Play a Key Role in Flow-Mediated Dilation in Human Coronary Resistance Arteries

2003 • 317 citations

Ischemic Tolerance

2002 • 298 citations

Dietary factors, hormesis and health

2007 • 276 citations

Neuroprotective role of astrocytes in cerebral ischemia: Focus on ischemic preconditioning

2005 • 262 citations

Activation of Mitochondrial ATP-Dependent Potassium Channels Protects Neurons against Ischemia-Induced Death by a Mechanism Involving Suppression of Bax Translocation and Cytochrome c Release

2002 • 214 citations

Hypoglycemia, brain energetics, and hypoglycemic neuronal death

2007 • 196 citations

The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury

1999 • 189 citations

Effects of the BK_Ca channel activator, NS1619, on rat cerebral artery smooth muscle

1996 • 168 citations

Mitochondrial nitric oxide synthase

2003 • 153 citations

Ion channel modulation by NS 1619, the putative BK_Ca channel opener, in vascular smooth muscle

1994 • 151 citations

Diazoxide induces delayed pre‐conditioning in cultured rat cortical neurons

2003 • 141 citations

Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance

2006 • 133 citations

Cardiac mitochondrial preconditioning by Big Ca²⁺-sensitive K⁺ channel opening requires superoxide radical generation

2005 • 132 citations

Cerebrovascular Dysfunction in Zucker Obese Rats Is Mediated by Oxidative Stress and Protein Kinase C

2004 • 131 citations

Targeting mitochondrial ATP-sensitive potassium channels—a novel approach to neuroprotection

2004 • 126 citations

Mitochondrial NO and reactive nitrogen species production: Does mtNOS exist?

2005 • 123 citations

MitoK_ATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat

2002 • 120 citations

Ca2+ signalling in mitochondria: mechanism and role in physiology and pathology

2003 • 110 citations

Prolonged anoxic survival due to anoxia pre-exposure: brain ATP, lactate, and pyruvate

1964 • 110 citations

Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice

2008 • 105 citations

Mitochondrial Potassium Channel Opener Diazoxide Preserves Neuronal-Vascular Function After Cerebral Ischemia in Newborn Pigs

1999 • 105 citations

Role of Reactive Oxygen Species and Protein Kinase C in Ischemic Tolerance in the Brain

2005 • 101 citations

The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain

2006 • 101 citations

Molecular Composition of Mitochondrial ATP-sensitive Potassium Channels Probed by Viral Kir Gene Transfer

2000 • 100 citations

Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

2001 • 94 citations

β‐Oxidation of 5‐hydroxydecanoate, a Putative Blocker of Mitochondrial ATP‐Sensitive Potassium Channels

2003 • 88 citations

5‐Hydroxydecanoate is metabolised in mitochondria and creates a rate‐limiting bottleneck for β‐oxidation of fatty acids

2004 • 87 citations

Opening of Mitochondrial ATP-Sensitive Potassium Channels Is a Trigger of 3-Nitropropionic Acid–Induced Tolerance to Transient Focal Cerebral Ischemia in Rats

2003 • 86 citations

Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain

2003 • 86 citations

BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice cultures

2002 • 82 citations

Global Ischemia Impairs ATP-Sensitive K ⁺ Channel Function in Cerebral Arterioles in Piglets

1996 • 82 citations

Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells

2003 • 80 citations

Potassium Channel Dysfunction in Cerebral Arteries of Insulin-Resistant Rats Is Mediated by Reactive Oxygen Species

2004 • 79 citations

Mitochondrial potassium channels: From pharmacology to function

2006 • 78 citations

The Maxi-K Channel Opener BMS-204352 Attenuates Regional Cerebral Edema and Neurologic Motor Impairment after Experimental Brain Injury

2001 • 75 citations

Mechanisms of neuroprotection during ischemic preconditioning: Lessons from anoxic tolerance

2006 • 69 citations

Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation

2004 • 67 citations

Diazoxide preconditioning attenuates global cerebral ischemia-induced blood–brain barrier permeability

2005 • 66 citations

The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning

2004 • 66 citations

Excitotoxicity and mitochondria

1999 • 65 citations

Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria

2005 • 64 citations

The Mitochondrial K_ATP Channel Opener BMS-191095 Reduces Neuronal Damage after Transient Focal Cerebral Ischemia in Rats

2006 • 62 citations

Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels

2007 • 62 citations

Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats

2002 • 57 citations

Acute Treatment with Rosuvastatin Protects Insulin Resistant (C57BL/6J ob/ob) Mice against Transient Cerebral Ischemia

2008 • 51 citations

Large-Conductance Potassium Cation Channel Opener NS1619 Inhibits Cardiac Mitochondria Respiratory Chain

2004 • 50 citations

ROS-Independent Preconditioning in Neurons via Activation of mitoK_ATP Channels by BMS-191095

2008 • 50 citations

Diazoxide pretreatment induces delayed preconditioning in astrocytes against oxygen glucose deprivation and hydrogen peroxide‐induced toxicity

2003 • 47 citations

The K+ channel openers diazoxide and NS1619 induce depolarization of mitochondria and have differential effects on cell Ca2+ in CD34+ cell line KG-1a

2003 • 47 citations

Potassium channel openers induce mitochondrial matrix volume changes via activation of ATP-sensitive K+ channel.

1993 • 45 citations

Diazoxide prevents mitochondrial swelling and Ca 2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs

2004 • 44 citations

Lack of mitochondrial nitric oxide production in the mouse brain

2004 • 42 citations

Mitochondria produce reactive nitrogen species via an arginine-independent pathway

2006 • 41 citations

Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons

2006 • 39 citations

Potassium Channel Activators Protect the N -Methyl- <scp>d</scp> -Aspartate–Induced Cerebral Vascular Dilation After Combined Hypoxia and Ischemia in Piglets

1998 • 35 citations

Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats

2007 • 32 citations

Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets

2005 • 29 citations

Protective Effect of Mitochondrial KATP Activation in an Isolated Gracilis Model of Ischemia and Reperfusion in Dogs

2003 • 19 citations

Neuroprotection by Diazoxide in Animal Models for Cerebrovascular Disorders

2006 • 6 citations

Deleted Work

1955 • 0 citations