Apoptosis and Alzheimer’s Disease

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Identification and characterization of a spinal muscular atrophy-determining gene

1995 • 3,722 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

APRIORITY

1961 • 1,293 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1995 • 976 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1995 • 774 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 • 646 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions

1980 • 556 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

1995 • 478 citations

Neural apoptosis

1995 • 464 citations

Definition and incidence of apoptosis : an historical perspective

1991 • 458 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1995 • 450 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

Synaptic loss in Alzheimer's disease and other dementias

1989 • 406 citations

Inhibition of PC12 cell redox activity is a specific,early indicator of the mechanism of beta-amyloid-mediated celldeath.

1994 • 406 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

1993 • 379 citations

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1994 • 372 citations

Amyloid peptides are toxic via a common oxidative mechanism.

1995 • 372 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

1990 • 334 citations

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

1995 • 334 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Evidence of apoptotic cell death in HIV encephalitis.

1995 • 297 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

1995 • 289 citations

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

1990 • 282 citations

A system for characterizing cellular and molecular events in programmed neuronal cell death

1993 • 267 citations

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases.

1995 • 265 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.

1994 • 251 citations

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

1989 • 238 citations

Apoptosis and Its Role in Human Disease

1994 • 232 citations

Detection of the initial stages of DNA fragmentation in apoptosis.

1993 • 228 citations

The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells

1993 • 222 citations

Cell death and the cell cycle: a relationship between transformation and neurodegeneration?

1993 • 205 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

1995 • 193 citations

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

1994 • 184 citations

Increased Immunoreactivity for Jun- and Fos-Related Proteins in Alzheimer's Disease: Association with Pathology

1994 • 173 citations

Soluble β-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K ⁺ Channels

1994 • 168 citations

Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

1991 • 160 citations

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

1995 • 156 citations

Biochemical characterization of programmed cell death in NGF‐deprived sympathetic neurons

1992 • 146 citations

Differential Induction of Immediate Early Gene Proteins in Cultured Neurons by β‐Amyloid (Aβ): Association of c‐Jun with Aβ‐Induced Apoptosis

1995 • 136 citations

β-Amyloid induces neuritic dystrophy in vitro

1992 • 132 citations

Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

1995 • 130 citations

Bcl-2 affects survival but not neuronal differentiation of PC12 cells

1993 • 129 citations

Activation of intracellular proteases is an early event in TNF-induced apoptosis.

1995 • 129 citations

Channel Formation in Planar Lipid Bilayers by a Neurotoxic Fragment of the β-Amyloid Peptide

1994 • 127 citations

Apoptosis II: The Molecular Basis of Apoptosis in Disease

1994 • 126 citations

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity.

1994 • 125 citations

Tau protein I is essential for amyloid β-protein iduced neurotoxicity

1993 • 125 citations

Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated

1991 • 123 citations

lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase

1994 • 115 citations

Defective glia induce neuronal apoptosis in the repo visual system of Drosophila

1995 • 111 citations

Function and expression of the Bcl-x gene in the developing and adult nervous system

1995 • 91 citations

Programmed Cell Death: New Thoughts and Relevance to Aging

1990 • 90 citations

c-fos protein-like immunoreactivity: Distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer's disease

1992 • 83 citations

The molecular mechanisms of neuronal apoptosis

1994 • 64 citations

Cellular senescence: A reflection of normal growth control, differentiation, or aging?

1991 • 63 citations

Apoptosis of bcl-x-deficient telencephalic cells in vitro

1996 • 59 citations

Expression of clusterin in cell differentiation and cell death

1994 • 51 citations

Molecular genetics of neuronal survival

1995 • 48 citations

Possible role of neuronal apoptosis in Alzheimer's disease

1994 • 35 citations

The role of β-amyloid peptide in alzheimer's disease

1994 • 7 citations

Deleted Work

1955 • 0 citations