4-Hydroxy-2-nonenal and uncoupling proteins: an approach for regulation of mitochondrial ROS production

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

1997 • 1,695 citations

Superoxide activates mitochondrial uncoupling proteins

2002 • 1,364 citations

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

2000 • 1,068 citations

A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

1997 • 756 citations

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

1996 • 699 citations

Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice

2000 • 679 citations

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

2003 • 587 citations

ΔΨ_m‐Dependent and ‐independent production of reactive oxygen species by rat brain mitochondria

2001 • 586 citations

Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

2004 • 457 citations

Untitled

1997 • 432 citations

Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

2002 • 386 citations

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

2003 • 358 citations

Uncoupling proteins 2 and 3 are highly active H ⁺ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

2001 • 318 citations

Superoxide and hydrogen peroxide production by Drosophila mitochondria

2003 • 301 citations

Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

2003 • 296 citations

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

2003 • 296 citations

The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

2003 • 222 citations

Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria

1997 • 220 citations

A history of the first uncoupling protein, UCP1.

1999 • 194 citations

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2

1999 • 192 citations

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

2002 • 187 citations

Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production

2004 • 184 citations

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2

2001 • 172 citations

Uncoupling proteins: the issues from a biochemist point of view

2001 • 168 citations

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

2001 • 141 citations

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

2003 • 132 citations

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells

2002 • 113 citations

Coenzyme Q induces GDP-sensitive proton conductance in kidney mitochondria

2001 • 50 citations