Breaking the mitochondrial barrier

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Structure of Bax

2000 • 1,066 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

Apoptotic Pathways

2000 • 993 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Mitochondria and cell death

1999 • 763 citations

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

2000 • 619 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

2000 • 447 citations

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

2000 • 428 citations

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

2000 • 415 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c

2000 • 335 citations

Interdigital cell death can occur through a necrotic and caspase-independent pathway

1999 • 316 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

Proapoptotic BH3-only Bcl-2 family members induce cytochromecrelease, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

2000 • 273 citations

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

2000 • 244 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

TNF-α Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K

2000 • 196 citations

Two Structural Transitions in Membrane Pore Formation by Pneumolysin, the Pore-Forming Toxin of Streptococcus pneumoniae

1999 • 181 citations

Biochemical and Genetic Analysis of the Mitochondrial Response of Yeast to BAX and BCL-X_L

2000 • 161 citations

Investigation of bax‐induced release of cytochrome c from yeast mitochondria

1999 • 131 citations

Energy supply and the shape of death in neurons and lymphoid cells

1997 • 122 citations

Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential

1998 • 91 citations

Comparison of the effects of bax‐expression in yeast under fermentative and respiratory conditions: investigation of the role of adenine nucleotides carrier and cytochrome c

1999 • 65 citations

The cytotoxic action of Bax on yeast cells does not require mitochondrial ADP/ATP carrier but may be related to its import to the mitochondria

2000 • 48 citations