Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

T Cell Anergy

2003 • 1,418 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

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Molecular mechanisms of alcohol-mediated carcinogenesis

2007 • 1,039 citations

β-Cell death during progression to diabetes

2001 • 883 citations

Selecting and maintaining a diverse T-cell repertoire

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Scaling down imaging: molecular mapping of cancer in mice

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eIF-4E expression and its role in malignancies and metastases

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The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Central tolerance: learning self-control in the thymus

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The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

2007 • 508 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

2008 • 383 citations

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines

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Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

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Matrix2png: a utility for visualizing matrix data

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

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Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

Deubiquitylation and regulation of the immune response

2008 • 325 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

GRAIL

2003 • 280 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy

2007 • 268 citations

Otubains: a new family of cysteine proteases in the ubiquitin pathway

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E3 ubiquitin ligases as T cell anergy factors

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Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response.

1995 • 220 citations

Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs.

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Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

Molecular regulation of interleukin‐2 expression by CD28 co‐stimulation and anergy

1998 • 190 citations

Molecular mechanisms of CD4+ T-cell anergy

2007 • 189 citations

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

2003 • 168 citations

TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet

2005 • 154 citations

Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

2002 • 143 citations

p70^s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

1999 • 138 citations

The majority of CD4+8- thymocytes are functionally immature.

1991 • 137 citations

Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin

2006 • 128 citations

mTOR at the crossroads of T cell proliferation and tolerance

2007 • 105 citations

The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells

2004 • 99 citations

Peripheral Expression of Self-MHC-II Influences the Reactivity and Self-Tolerance of Mature CD4+ T Cells

2002 • 94 citations

A Novel E3 Ubiquitin Ligase Substrate Screen Identifies Rho Guanine Dissociation Inhibitor as a Substrate of Gene Related to Anergy in Lymphocytes

2006 • 73 citations

The Single Subunit Transmembrane E3 Ligase Gene Related to Anergy in Lymphocytes (GRAIL) Captures and Then Ubiquitinates Transmembrane Proteins across the Cell Membrane

2008 • 69 citations

The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells

2007 • 67 citations

Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice

2008 • 66 citations

The induction and maintenance of T cell anergy

2006 • 63 citations

The control of T cell activation vs. tolerance

2003 • 62 citations

Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy

2008 • 57 citations

Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice

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Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset.

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Clonal Anergy Is Maintained Independently of T Cell Proliferation

2002 • 49 citations

p27Kip1 Regulates T Cell Proliferation

2001 • 48 citations

Up-Regulation of Gene Related to Anergy in Lymphocytes Is Associated with Notch-Mediated Human T Cell Suppression

2007 • 42 citations

Casitas B-Lineage Lymphoma b Inhibits Antigen Recognition and Slows Cell Cycle Progression at Late Times during CD4+ T Cell Clonal Expansion

2008 • 22 citations

Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys

2006 • 20 citations

Upregulation of GRAIL is associated with remission of ulcerative colitis

2008 • 14 citations

Sustained B7/CD28 interactions and resultant phosphatidylinositol 3‐kinase activity maintain G₁→S phase transitions at an optimal rate

2006 • 14 citations

Preservation of self: An overview of E3 ubiquitin ligases and T cell tolerance

2007 • 13 citations

CD4+ T-cell responses to self-peptide–MHC

2003 • 10 citations