Casitas B-Lineage Lymphoma b Inhibits Antigen Recognition and Slows Cell Cycle Progression at Late Times during CD4+ T Cell Clonal Expansion

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

Egr-2 and Egr-3 are negative regulators of T cell activation

2005 • 431 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Dynamic programming of CD8+ T lymphocyte responses

2003 • 401 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

2005 • 271 citations

A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy

2007 • 268 citations

Sustained Survivin Expression from OX40 Costimulatory Signals Drives T Cell Clonal Expansion

2005 • 243 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections

2009 • 202 citations

Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation

2007 • 187 citations

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

2002 • 172 citations

Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

2002 • 143 citations

Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin

2006 • 128 citations

Transcriptional Regulation of the Gene Encoding the Human C-type Lectin Leukocyte Receptor AIM/CD69 and Functional Characterization of Its Tumor Necrosis Factor-α-responsive Elements

1995 • 123 citations

The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes

2006 • 123 citations

Visualizing T Cell Competition for Peptide/MHC Complexes

2000 • 107 citations

T-Cell Receptor-Induced NF-κB Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b

2008 • 91 citations

Competition for antigen determines the stability of T cell–dendritic cell interactions during clonal expansion

2007 • 87 citations

Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness

2001 • 85 citations

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation

2007 • 77 citations

Analysis of specificity for antigen, Mls, and allogeneic MHC by transfer of T-cell receptor α- and β-chain genes

1988 • 52 citations

Clonal Anergy Is Maintained Independently of T Cell Proliferation

2002 • 49 citations

Cbl-b Regulates Antigen-Induced TCR Down-Regulation and IFN-γ Production by Effector CD8 T Cells without Affecting Functional Avidity

2007 • 47 citations

Cutting Edge: B7/CD28 Interactions Regulate Cell Cycle Progression Independent of the Strength of TCR Signaling

2002 • 42 citations

Proliferating CD4+ T Cells Undergo Immediate Growth Arrest upon Cessation of TCR Signaling In Vivo

2008 • 24 citations

Sustained B7/CD28 interactions and resultant phosphatidylinositol 3‐kinase activity maintain G₁→S phase transitions at an optimal rate

2006 • 14 citations