Upregulation of GRAIL is associated with remission of ulcerative colitis

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

T Cell Anergy

2003 • 1,418 citations

Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial.

1989 • 1,035 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

Peripheral and Intestinal Regulatory CD4+CD25high T Cells in Inflammatory Bowel Disease

2005 • 604 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Oral tolerance

2005 • 573 citations

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

2005 • 477 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

1989 • 316 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

GRAIL

2003 • 280 citations

T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

1999 • 261 citations

E3 ubiquitin ligases as T cell anergy factors

2004 • 224 citations

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

2003 • 168 citations

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease☆

2004 • 159 citations

Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.

1995 • 125 citations

Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation?

2005 • 120 citations

Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses

2001 • 114 citations

The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells

2004 • 99 citations

Serum antibodies to cow's milk proteins in ulcerative colitis and Crohn's disease

1987 • 98 citations

GRAIL Is Up-regulated in CD4+ CD25+ T Regulatory Cells and Is Sufficient for Conversion of T Cells to a Regulatory Phenotype

2007 • 68 citations

Structural basis of ubiquitylation

2002 • 64 citations

Up-Regulation of Gene Related to Anergy in Lymphocytes Is Associated with Notch-Mediated Human T Cell Suppression

2007 • 42 citations

Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens.

1999 • 38 citations

Clonal Expansion of CD4+ TCRββ+ T Cells in TCR α-Chain- Deficient Mice by Gut-Derived Antigens

1999 • 34 citations

Induction of mucosal immune responses by bacteria and bacterial components

2001 • 26 citations

Leukocytapheresis Therapy Modulates Circulating T cell Subsets in Patients With Ulcerative Colitis

2005 • 25 citations

Centrifugal Leukocyte Apheresis for Ulcerative Colitis

1998 • 17 citations