Designing and Maintaining the Mature TCR Repertoire

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Negative selection of lymphocytes

1994 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Positive Selection of Thymocytes

1995 • 604 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Positive selection of lymphocytes

1994 • 563 citations

Selective Events in T Cell Development

1994 • 486 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

On the complexity of self

1991 • 261 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

A novel MHC class II epitope expressed in thymic medulla but not cortex

1989 • 175 citations

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8⁺ T cell pools

1995 • 174 citations

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

1990 • 170 citations

On the cellular basis of immunological T cell memory

1995 • 159 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Peripheral Selection of T Cell Repertoires: The Role of Continuous Thymus Output

1997 • 134 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

Monoclonal antibody detection of a major self peptide. MHC class II complex.

1992 • 127 citations

Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice

1997 • 122 citations

MHC and T cell development.

1999 • 108 citations

The Imprint of Intrathymic Self-Peptides on the Mature T Cell Receptor Repertoire

1997 • 105 citations

Expansion of mature thymocyte subsets before emigration to the periphery.

1997 • 86 citations

Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.

1997 • 83 citations

Thymic selection and cell division.

1995 • 83 citations

Antigen Receptor Signaling Gives Lymphocytes a Long Life

1997 • 75 citations

Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides

1998 • 42 citations

T-cell development, survival, and signalling: A new concept of the role of self-peptide: Self-MHC complexes

1998 • 17 citations