The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

2000 • 1,801 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

2005 • 856 citations

The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

2006 • 685 citations

The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

2004 • 674 citations

Cellular and genetic mechanisms of self tolerance and autoimmunity

2005 • 671 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

2007 • 562 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Bortezomib: Proteasome Inhibition as an Effective Anticancer Therapy

2006 • 354 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

The ubiquitin–protein ligase Itch regulates p73 stability

2005 • 300 citations

GRAIL

2003 • 280 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

2003 • 269 citations

The Ubiquitin-Proteasome System and Its Role in Inflammatory and Autoimmune Diseases

2006 • 265 citations

Proteasome inhibitors: antitumor effects and beyond

2006 • 226 citations

E3 ubiquitin ligases as T cell anergy factors

2004 • 224 citations

The E3 ubiquitin ligase Itch controls the protein stability of p63

2006 • 216 citations

Cbl-b Is a Negative Regulator of Receptor Clustering and Raft Aggregation in T Cells

2000 • 211 citations

Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

TRAF6 is a T cell–intrinsic negative regulator required for the maintenance of immune homeostasis

2006 • 200 citations

Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma

2003 • 199 citations

Central tolerance: good but imperfect

2006 • 196 citations

Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo

2000 • 178 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-β Sensitivity In Vitro and In Vivo

2006 • 138 citations

Spontaneous tumor rejection by cbl-b–deficient CD8+ T cells

2007 • 136 citations

The role of TRAF6 in signal transduction and the immune response

2004 • 134 citations

Ndfip1 Protein Promotes the Function of Itch Ubiquitin Ligase to Prevent T Cell Activation and T Helper 2 Cell-Mediated Inflammation

2006 • 131 citations

Control of the B Cell-Intrinsic Tolerance Programs by Ubiquitin Ligases Cbl and Cbl-b

2007 • 124 citations

Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− Mice

2004 • 120 citations

N4WBP5, a Potential Target for Ubiquitination by the Nedd4 Family of Proteins, Is a Novel Golgi-associated Protein

2002 • 115 citations

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors

2007 • 111 citations

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

2000 • 106 citations

The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells

2004 • 99 citations

E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury

2007 • 93 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS

2000 • 86 citations

PKCθ Signals Activation versus Tolerance In Vivo

2004 • 84 citations

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

2001 • 81 citations

Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator

2006 • 81 citations

A Novel E3 Ubiquitin Ligase Substrate Screen Identifies Rho Guanine Dissociation Inhibitor as a Substrate of Gene Related to Anergy in Lymphocytes

2006 • 73 citations

Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner

2004 • 71 citations

GRAIL Is Up-regulated in CD4+ CD25+ T Regulatory Cells and Is Sufficient for Conversion of T Cells to a Regulatory Phenotype

2007 • 68 citations

The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance

2007 • 58 citations

What's new in the Aire?

2007 • 58 citations

TNF Receptor-Associated Factor 6 Deficiency during Hemopoiesis Induces Th2-Polarized Inflammatory Disease

2003 • 57 citations

CBLBvariants in type 1 diabetes and their genetic interaction withCTLA4

2005 • 45 citations

A comparative study of mRNA and protein expression of the autoimmune regulator gene (Aire) in embryonic and adult murine tissues

2004 • 41 citations

Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications

2006 • 32 citations

Use of Systemic Proteasome Inhibition as an Immune-Modulating Agent in Disease

2007 • 32 citations

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

2000 • 31 citations

The Proteasome and Its Inhibitors in Immune Regulation and Immune Disorders

2006 • 28 citations

Lessons on immune tolerance from the monogenic disease APS1

2007 • 27 citations

The TRAF6-NF kappa B signaling pathway in autoimmunity: not just inflammation.

2005 • 25 citations

A Molecular Dissection of Lymphocyte Unresponsiveness Induced by Sustained Calcium Signalling

2005 • 24 citations

Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection

2006 • 17 citations

Regulation of Immune Responses by E3 Ubiquitin-Protein Ligases

2001 • 11 citations

Aire‐ing self antigen variability and tolerance

2007 • 6 citations