eIF-4E expression and its role in malignancies and metastases

The Hallmarks of Cancer

2000 • 27,569 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Angiogenic Factors

1987 • 3,702 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

2001 • 981 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten^+/−mice

2001 • 574 citations

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

1989 • 572 citations

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

1998 • 496 citations

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.

1987 • 494 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells

2003 • 445 citations

Model for the regulation of mRNA translation applied to haemoglobin synthesis

1974 • 416 citations

mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E.

1992 • 414 citations

Translational control of C/EBPα and C/EBPβ isoform expression

2000 • 402 citations

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

1996 • 394 citations

Fibroblast growth factor: Structural and biological properties

1987 • 334 citations

Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes

1995 • 332 citations

C-Myc 5′ untranslated region contains an internal ribosome entry segment

1998 • 319 citations

A Cell Cycle–Dependent Internal Ribosome Entry Site

2000 • 319 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Does phosphorylation of the cap‐binding protein eIF4E play a role in translation initiation?

2002 • 296 citations

Rapamycins: Mechanisms of Action and Cellular Resistance

2003 • 290 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Elevated Levels of Cyclin D1 Protein in Response to Increased Expression of Eukaryotic Initiation Factor 4E

1993 • 270 citations

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

1995 • 268 citations

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle

1988 • 256 citations

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.

1986 • 247 citations

Antisense therapy in oncology: new hope for an old idea?

2001 • 233 citations

An Essential E Box in the Promoter of the Gene Encoding the mRNA Cap-Binding Protein (Eukaryotic Initiation Factor 4E) Is a Target for Activation by c-myc

1996 • 232 citations

Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.

1990 • 225 citations

Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs.

2003 • 219 citations

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

1996 • 218 citations

Initiation codons within 5′-leaders of mRNAs as regulators of translation

1994 • 207 citations

Rapamycin is an effective inhibitor of human renal cancer metastasis11See Editorial by Sukhatme and Strom, p. 1160.

2003 • 204 citations

Translational activation of the lck proto-oncogene

1988 • 203 citations

Immunological detection of the messenger RNA cap-binding protein.

1985 • 201 citations

Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: Implications for tumor angiogenesis

1996 • 199 citations

Activation of the c-myc gene by translocation: a model for translational control.

1983 • 196 citations

Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases

2001 • 181 citations

The proto‐oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas

1995 • 180 citations

The 5′ Untranslated Sequence of the c-sis/Platelet-Derived Growth Factor 2 Transcript Is a Potent Translational Inhibitor

1988 • 180 citations

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

1999 • 175 citations

Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer

1997 • 173 citations

Repression of p27^kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells

1996 • 168 citations

Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E

1991 • 168 citations

Translational Control of Programmed Cell Death: Eukaryotic Translation Initiation Factor 4E Blocks Apoptosis in Growth-Factor-Restricted Fibroblasts with Physiologically Expressed or Deregulated Myc

1996 • 164 citations

Metastasis suppressor pathways—an evolving paradigm

2003 • 160 citations

Expression of Antisense RNA against Initiation Factor eIF-4E mRNA in HeLa Cells Results in Lengthened Cell Division Times, Diminished Translation Rates, and Reduced Levels of Both eIF-4E and the p220 Component of eIF-4F

1991 • 151 citations

Ras mediates translation initiation factor 4E-induced malignant transformation.

1992 • 146 citations

Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma

1997 • 143 citations

Fibroblast Growth Factor-2 Induces Translational Regulation of Bcl-XL and Bcl-2 via a MEK-dependent Pathway

2002 • 143 citations

Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression

2000 • 138 citations

Expression of the Eukaryotic Translation Initiation Factors 4E and 2α in Non-Hodgkin's Lymphomas

1999 • 138 citations

Cap recap: The involvement of eIF-4F in regulating gene expression

1992 • 134 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells

1998 • 127 citations

Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas

1997 • 125 citations

Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E

1998 • 118 citations

Translation Factor eIF4E Rescues Cells from Myc-dependent Apoptosis by Inhibiting Cytochromec Release

2003 • 114 citations

Decreasing the level of translation initiation factor 4E with antisense rna causes reversal of ras‐mediated transformation and tumorigenesis of cloned rat embryo fibroblasts

1993 • 114 citations

Role of two upstream open reading frames in the translational control of oncogene mdm2

1999 • 112 citations

Translational Control of the Antiapoptotic Function of Ras

2000 • 112 citations

Reduction of translation initiation factor 4E decreases the malignancy of ras ‐transformed cloned rat embryo fibroblasts

1995 • 112 citations

Translational discrimination of mRNAs coding for human insulin-like growth factor II.

1990 • 108 citations

Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region.

1985 • 104 citations

Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1

2000 • 103 citations

Expression of eukaryotic translation initiation factors 4E and 2? is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

2001 • 100 citations

A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed

2001 • 99 citations

The involvement of mRNA secondary structure in protein synthesis

1987 • 98 citations

Clinical Outcome in Stage I to III Breast Carcinoma and eIF4E Overexpression

1998 • 93 citations

Molecular Cloning and Structure of the Human Transforming Growth Factor-β2 Gene Promoter

1991 • 92 citations

Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.

2001 • 86 citations

Antisense RNA to eIF4E Suppresses Oncogenic Properties of a Head and Neck Squamous Cell Carcinoma Cell Line

2000 • 86 citations

Mechanism of Action and Regulation of Protein Synthesis Initiation Factor 4E: Effects on mRNA Discrimination, Cellular Growth Rate, and Oncogenesis

1993 • 85 citations

Prospective Study of Eukaryotic Initiation Factor 4E Protein Elevation and Breast Cancer Outcome

2002 • 77 citations

The 5′-Untranslated Region of the N-Methyl-D-aspartate Receptor NR2A Subunit Controls Efficiency of Translation

1996 • 76 citations

Detection of the Proto-oncogene eIF4E in Larynx and Hypopharynx Cancers

1999 • 69 citations

Translational control of ornithine aminotransferase. Modulation by initiation factor eIF-4E.

1991 • 66 citations

Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma

2002 • 65 citations

Overexpression of the proto-oncogene/translation factor 4E in breast-carcinoma cell lines

1996 • 64 citations

Induction of Mesoderm in Xenopus laevis Embryos by Translation Initiation Factor 4E

1994 • 64 citations

Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines

1995 • 62 citations

Translational Regulation of the JunD Messenger RNA

2002 • 59 citations

Elevated expression of eIF4E in confined early breast cancer lesions: Possible role of hypoxia

1999 • 57 citations

Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E: evidence for internal ribosome repositioning in the human c-myc 5′UTR

1999 • 50 citations

Signal transduction mechanisms in the regulation of protein synthesis

1994 • 50 citations

Translation of ODC mRNA and Polyamine Transport Are Suppressed inras-Transformed CREF Cells by Depleting Translation Initiation Factor 4E

1997 • 47 citations

Translational Regulation of Ribonucleotide Reductase by Eukaryotic Initiation Factor 4E Links Protein Synthesis to the Control of DNA Replication

1999 • 47 citations

The mRNA 5' Cap-Binding Protein, eIF-4E, Cooperates with v-myc or E1A in the Transformation of Primary Rodent Fibroblasts

1992 • 47 citations

Expression of heparanase in human tumor cell lines and human head and neck tumors

2003 • 42 citations

Selective killing of cancer cells based on translational control of a suicide gene

2002 • 35 citations

Role of the 5′-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine

1994 • 34 citations

Cloning and Characterization of Human eIF4E Genes

1998 • 30 citations

A cancer gene therapy approach through translational control of a suicide gene

2002 • 28 citations

AMPLIFICATION OF TRANSLATIONAL CONTROL BY MEMBRANE‐MEDIATED EVENTS: A PLEIOTROPIC EFFECT ON CELLULAR AND VIRAL GENE EXPRESSION*

1980 • 27 citations

c-myc Amplification in a preleukemia patient with trisomy 4 and double minutes: Review of the unique coexistence of these two chromosome abnormalities in acute myelogenous leukemia

1997 • 22 citations

Cell type-dependent and -independent control of HER-2/neu translation

1999 • 19 citations

The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo

1997 • 14 citations

Inhibition of Translation of Transforming Growth Factor-β3 mRNA by Its 5′ Untranslated Region

1991 • 6 citations