A selective role of calcineurin Aα in synaptic depotentiation in hippocampus

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Roles of N-Type and Q-Type Ca ²⁺ Channels in Supporting Hippocampal Synaptic Transmission

1994 • 964 citations

Contrasting properties of two forms of long-term potentiation in the hippocampus

1995 • 839 citations

An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

1993 • 678 citations

Two Distinct Forms of Long-Term Depression Coexist in CA1 Hippocampal Pyramidal Cells

1997 • 547 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

The CaM kinase II hypothesis for the storage of synaptic memory

1994 • 510 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

Protein Serine/Threonine Phosphatases—New Avenues for Cell Regulation

1994 • 424 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

1998 • 355 citations

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

1997 • 340 citations

Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

1995 • 326 citations

MOLECULAR GENETIC ANALYSIS OF SYNAPTIC PLASTICITY, ACTIVITY-DEPENDENT NEURAL DEVELOPMENT, LEARNING, AND MEMORY IN THE MAMMALIAN BRAIN

1997 • 299 citations

Low-frequency stimulation erases LTP through an NMDA receptor-mediated activation of protein phosphatases.

1994 • 281 citations

Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase.

1995 • 212 citations

An investigation of depotentiation of longterm potentiation in the CA1 region of the hippocampus

1994 • 195 citations

Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase.

1996 • 169 citations

Factors regulating the reversibility of long-term potentiation

1996 • 158 citations

T cell responses in calcineurin A alpha-deficient mice.

1996 • 149 citations

Gating by Cyclic AMP: Expanded Role for an Old Signaling Pathway

1996 • 128 citations

Distinct Cellular Expression of Calcineurin Aα and Aβ in Rat Brain

1992 • 127 citations

Differential distribution of the mRNA encoding two isoforms of the catalytic subunit of calcineurin in the rat brain

1991 • 68 citations

The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions.

1992 • 66 citations

Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus

1996 • 57 citations

Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation

1994 • 48 citations

Differential subcellular localization of neural isoforms of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin) in central nervous system neurons: immunohistochemistry on formalin-fixed paraffin sections employing antigen retrieval by microwave irradiation.

1996 • 47 citations

FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus

1996 • 36 citations

Only ‘de novo’ long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex

1995 • 35 citations