Cain, A Novel Physiologic Protein Inhibitor of Calcineurin

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The scanning model for translation: an update.

1989 • 3,525 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 • 1,872 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

A new efficient gene disruption cassette for repeated use in budding yeast

1996 • 1,609 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1994 • 818 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

1995 • 749 citations

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

1979 • 724 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

A huntingtin-associated protein enriched in brain with implications for pathology

1995 • 597 citations

Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

1996 • 557 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.

1992 • 531 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

1995 • 484 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

Differential immunohistochemical localization of inositol 1,4,5- trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain

1993 • 435 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA

1991 • 399 citations

Restricted and Regulated Overexpression Reveals Calcineurin as a Key Component in the Transition from Short-Term to Long-Term Memory

1998 • 365 citations

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

1998 • 355 citations

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

1993 • 353 citations

Somatic Mutations in Paroxysmal Nocturnal Hemoglobinuria: A Blessing in Disguise?

1997 • 305 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

1995 • 288 citations

The dynamins: Redundant or distinct functions for an expanding family of related GTPases?

1997 • 286 citations

Superoxide dismutase protects calcineurin from inactivation

1996 • 270 citations

Identification of an autoinhibitory domain in calcineurin.

1990 • 268 citations

Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription

1997 • 239 citations

Molecular Mechanisms in Synaptic Vesicle Endocytosis and Recycling

1996 • 229 citations

Long-lasting forms of synaptic potentiation in the mammalian hippocampus.

1996 • 222 citations

Calcineurin Inhibition of Dynamin I GTPase Activity Coupled to Nerve Terminal Depolarization

1994 • 215 citations

Bench to Bedside: The Glutamate Connection

1992 • 206 citations

Recombinant NFAT1 (NFATp) Is Regulated by Calcineurin in T Cells and Mediates Transcription of Several Cytokine Genes

1996 • 192 citations

Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.

1994 • 162 citations

The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin

1994 • 141 citations

Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate.

1994 • 126 citations

A biochemist's view of long-term potentiation.

1996 • 117 citations

Postsynaptic Calcineurin Activity Downregulates Synaptic Transmission by Weakening Intracellular Ca²⁺Signaling Mechanisms in Hippocampal CA1 Neurons

1997 • 111 citations

Developmental Expression Pattern of Phototransduction Components in Mammalian Pineal Implies a Light-Sensing Function

1997 • 111 citations

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp)

1996 • 104 citations

Memory and behavior: a second generation of genetically modified mice

1997 • 65 citations

A Role for Calcineurin (Protein Phosphatase-2B) in the Regulation of Glutamate Release

1995 • 48 citations

FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus

1996 • 36 citations

Molecular Neurobiology

1990 • 33 citations