Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells.

1990 • 260 citations

Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function

1996 • 229 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1991 • 194 citations

Interleukin-1 signal transduction

1996 • 157 citations

Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.

1987 • 157 citations

CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

1994 • 132 citations

Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

1994 • 114 citations

A Sustained Reduction in IκB-β May Contribute to Persistent NF-κB Activation in Human Endothelial Cells

1996 • 110 citations

Regulation of IκBβ Degradation

1997 • 109 citations

Mechanism for Biphasic Rel A· NF-κB1 Nuclear Translocation in Tumor Necrosis Factor α-stimulated Hepatocytes

1997 • 103 citations

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.

1995 • 93 citations

c-Rel Is a Target of Pentoxifylline-Mediated Inhibition of T Lymphocyte Activation

1997 • 91 citations

Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product

1996 • 91 citations

CD28 Mediates a Potent Costimulatory Signal for Rapid Degradation of IκBβ Which Is Associated with Accelerated Activation of Various NF-κB/Rel Heterodimers

1996 • 70 citations

Monoclonal anti-human T-lymphocyte antibodies: enumeration and characterization of T-cell subsets.

1981 • 60 citations

Cyclosporin A sensitivity of the NF-χB site of the IL2Rα promoter in untransformed murine T cells

1994 • 44 citations

Biphasic control of nuclear factor‐χB activation by the T cell receptor complex: role of tumor necrosis factor α

1995 • 38 citations

Positive and negative regulation of IL-2 gene expression: Role of multiple regulatory sites

1994 • 22 citations

IL-1 receptor and TCR signals synergize to activate NF-κB-mediated gene transcription

1995 • 20 citations

T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506

1989 • 18 citations

Ligand-induced desensitization of interleukin 1 receptor-initiated intracellular signaling events in T helper lymphocytes.

1994 • 12 citations

Cyclosporin A inhibits induction of IL-2 receptor alpha chain expression by affecting activation of NF-kB-like factor(s) in cultured human T lymphocytes.

1990 • 10 citations

Activation of transcription factor NF kappa B in Jurkat cells is inhibited selectively by FK 506 in a signal-dependent manner.

1991 • 8 citations