Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

On target with a new mechanism for the regulation of protein phosphorylation

1993 • 901 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

1995 • 749 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

1993 • 389 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Calmodulin-binding domains: just two faced or multi-faceted?

1995 • 368 citations

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1990 • 353 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Signal integration at the level of protein kinases, protein phosphatases and their substrates

1992 • 314 citations

Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane

1994 • 305 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

The proliferation of MAP kinase signaling pathways in yeast

1995 • 243 citations

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.

1994 • 221 citations

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells Family That Is Expressed Predominantly in the Thymus

1995 • 211 citations

NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity

1995 • 168 citations

A Similar DNA-binding Motif in NFAT Family Proteins and the Rel Homology Region

1995 • 146 citations

Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding.

1995 • 139 citations

Interleukin-2 Transcription Is Regulated In Vivo at the Level of Coordinated Binding of Both Constitutive and Regulated Factors

1994 • 138 citations

Direct Demonstration of NFATp Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFATp Polyclonal Antibody

1995 • 134 citations

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

1994 • 125 citations

Cyclosporin-a sensitive induction of NF-AT in murine B cells

1994 • 124 citations

Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system.

1994 • 123 citations

NF-AT-AP-1 and Rel-bZIP: Hybrid vigor and binding under the influence

1994 • 118 citations

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp)

1996 • 104 citations

The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

1991 • 99 citations

Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells

1995 • 96 citations

Regulation of Interleukin 2 Gene Expression by CD28 Costimulation in Mouse T-Cell Clones: both Nuclear and Cytoplasmic RNAs Are Regulated with Complex Kinetics

1995 • 92 citations

Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells.

1994 • 92 citations

FcϵRI-mediated Induction of Nuclear Factor of Activated T-cells

1995 • 85 citations

Induction, suppression and superinduction of lymphokine mRNA in T lymphocytes

1987 • 82 citations

Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12.

1992 • 68 citations

Ionomycin activates electrogenic Ca2+ influx in rat thymic lymphocytes

1993 • 58 citations

Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies.

1984 • 57 citations

Association of Raf with the CD3 delta and gamma chains of the T cell receptor-CD3 complex.

1994 • 12 citations