Nucleocytoplasmic Shuttling Factors Including Ran and CRM1 Mediate Nuclear Export of NFAT In Vitro

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

A nuclear localization domain in the hnRNP A1 protein.

1995 • 510 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

1997 • 435 citations

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

1997 • 403 citations

Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.

1995 • 385 citations

Expression of recombinant plasmids in mammalian cells Is enhanced by sodium butyrate

1983 • 380 citations

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

1997 • 371 citations

Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1

1995 • 334 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

1993 • 290 citations

Sequence and characterization of cytoplasmic nuclear protein import factor p97.

1995 • 274 citations

O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteins.

1987 • 268 citations

From nucleoporins to nuclear pore complexes

1997 • 243 citations

Mechanisms of nuclear protein import

1995 • 241 citations

Reversible inhibition of protein import into the nucleus by wheat germ agglutinin injected into cultured cells

1987 • 233 citations

Nuclear export signals and the fast track to the cytoplasm

1995 • 229 citations

Inhibition of HIV-1 Replication in Lymphocytes by Mutants of the Rev Cofactor eIF-5A

1996 • 218 citations

Requirement of Guanosine Triphosphate-Bound Ran for Signal-Mediated Nuclear Protein Export

1997 • 183 citations

RNA Export

1995 • 181 citations

Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.

1996 • 177 citations

The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm.

1995 • 170 citations

Ran-unassisted Nuclear Migration of a 97-kD Component of Nuclear Pore–targeting Complex

1997 • 160 citations

Karyopherin β2 mediates nuclear import of a mRNA binding protein

1997 • 160 citations

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

1996 • 155 citations

Direct Demonstration of NFATp Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFATp Polyclonal Antibody

1995 • 134 citations

Export of mRNA from microinjected nuclei of Xenopus laevis oocytes.

1992 • 121 citations

RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.

1996 • 118 citations

Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis

1998 • 113 citations

Rapid targeting of nuclear proteins to the cytoplasm

1997 • 112 citations

Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation

1995 • 109 citations

Subnuclear Trafficking of Glucocorticoid Receptors In Vitro: Chromatin Recycling and Nuclear Export

1997 • 104 citations

Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells

1995 • 96 citations

[30] Analysis of Ran/TC4 function in nuclear protein import

1995 • 69 citations

Protein export from the nucleus requires the GTPase Ran and GTP hydrolysis.

1995 • 65 citations

The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N

1996 • 31 citations

Nucleocytoplasmic Recycling of the Nuclear Localization Signal Receptor α Subunit In Vivo Is Dependent on a Nuclear Export Signal, Energy, and RCC1

1997 • 22 citations

Energy- and Temperature-Dependent In Vitro Export of RNA from Synthetic Nuclei

1997 • 10 citations