Calcineurin Feedback Inhibition of Agonist-evoked cAMP Formation

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor

1986 • 874 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

Adenylyl cyclases and the interaction between calcium and cAMP signalling

1995 • 594 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

Cloning and expression of a widely distributed (type IV) adenylyl cyclase.

1991 • 363 citations

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

1992 • 338 citations

Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells.

1992 • 262 citations

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

1992 • 254 citations

Calcineurin Inhibition of Dynamin I GTPase Activity Coupled to Nerve Terminal Depolarization

1994 • 215 citations

Immunophilins and nervous system

1995 • 195 citations

Calcium channel regulation by calcineurin, a Ca2+-activated phosphatase in mammalian brain

1989 • 195 citations

Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity.

1986 • 187 citations

Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells.

1985 • 169 citations

Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI.

1992 • 159 citations

Calmodulin activates the isolated catalytic unit of brain adenylate cyclase.

1981 • 147 citations

FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin.

1989 • 137 citations

Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate.

1994 • 126 citations

Stimulation of Cyclic AMP Production by the Rat Testis During Incubation with hCGin Vitro

1973 • 99 citations

Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels in cardiac myocytes.

1993 • 85 citations

A Novel Adenylyl Cyclase Sequence Cloned from the Human Erythroleukemia Cell Line

1993 • 78 citations

Phosphorylation of Gi alpha 2 attenuates inhibitory adenylyl cyclase in neuroblastoma/glioma hybrid (NG-108-15) cells.

1994 • 57 citations

Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensin II.

1994 • 55 citations

Glucocorticoid inhibition of stimulus-evoked adrenocorticotrophin release caused by suppression of intracellular calcium signals

1992 • 55 citations

Pituitary corticotrope tumor (AtT20) cells as a model system for the study of early inhibition by glucocorticoids.

1992 • 49 citations

[9] Identification of adenylyl cyclases by amplification using degenerate primers

1994 • 49 citations

Antibiotics and antiviral compounds, chemical synthesis and modification

1994 • 44 citations

Characterization of bovine brain calmodulindependent protein phosphatase

1984 • 44 citations

Predominant expression of type-VI adenylate cyclase in C6-2B rat glioma cells may account for inhibition of cyclic AMP accumulation by calcium

1993 • 44 citations

Inhibitory Role for Calcineurin in Stimulus-Secretion Coupling Revealed by FK506 and Cyclosporin A in Pituitary Corticotrope Tumor Cells

1993 • 35 citations

Potent and cooperative feedback inhibition of adenylate cyclase activity by calcium in pituitary-derived GH3 cells

1990 • 31 citations

Phosphorylation of the recombinant spliced variants of the α-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase a

1992 • 27 citations

Activators of protein kinase C and cyclic AMP-dependent protein kinase regulate intracellular calcium levels through distinct mechanisms in mouse anterior pituitary tumor cells.

1987 • 27 citations

Selective Dephosphorylation of the Subunits of Skeletal Muscle Calcium Channels by Purified Phosphoprotein Phosphatases

1993 • 20 citations

Effects of adenosine 3′: 5′‐cyclic monophosphate and guanine nucleotides on calcium‐evoked ACTH release from electrically permeabilized AtT‐20 cells

1991 • 19 citations

Desensitization of beta2-adrenergic receptors and adrenocorticotropin release

1983 • 13 citations

Glucocorticoid Negative Feedback in Pituitary Corticotropes. Pivotal Role for Calcineurin Inhibition of Adenylyl Cyclase

1994 • 11 citations

Inhibition of protein phosphatases by okadaic acid and calyculin-a differentially modulates hormonal- and forskolin-stimulated formation of cyclic AMP in AtT-20 corticotrophs: Effect of pituitary adenylate activating polypeptide and corticotropin-releasing factor

1994 • 8 citations