DNA Methylation Profiles of Female Steroid Hormone-Driven Human Malignancies

DNA methylation patterns and epigenetic memory

2002 • 6,778 citations

Epigenetics in human disease and prospects for epigenetic therapy

2004 • 3,142 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

Mechanisms of Estrogen Action

2001 • 1,945 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

The power and the promise of DNA methylation markers

2003 • 1,544 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

RAF/RAS oncogenes and mismatch-repair status

2002 • 1,205 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

2000 • 1,182 citations

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

2001 • 997 citations

COX-2 is expressed in human pulmonary, colonic, and mammary tumors

2000 • 872 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

1993 • 749 citations

The genetic attributable risk of breast and ovarian cancer

1996 • 740 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 690 citations

Progestin Regulation of Cellular Proliferation*

1990 • 659 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

2001 • 626 citations

Etiology of Hormone Receptor–Defined Breast Cancer: A Systematic Review of the Literature

2004 • 621 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 589 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

2000 • 529 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Epigenetic patterns in the progression of esophageal adenocarcinoma.

2001 • 502 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi

1990 • 466 citations

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

2000 • 462 citations

DNA methylation and breast carcinogenesis

2002 • 452 citations

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

2001 • 445 citations

Methylation profiling of CpG islands in human breast cancer cells

1999 • 434 citations

Cancer incidence and mortality, 1973-1995

1998 • 406 citations

Metabolic epidemiology of colon cancer:Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps

1977 • 404 citations

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

1999 • 392 citations

Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours

2001 • 379 citations

ERβ Inhibits Proliferation and Invasion of Breast Cancer Cells

2001 • 376 citations

A systematic profile of DNA methylation in human cancer cell lines.

2003 • 367 citations

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

1994 • 366 citations

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

1998 • 366 citations

Epidemiology and Prevention of Breast Cancer

1996 • 365 citations

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

1999 • 353 citations

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

1999 • 350 citations

Epigenomics: beyond CpG islands

2004 • 347 citations

Reproduction, Endogenous and Exogenous Sex Hormones, and Colon Cancer: A Review and Hypothesis

1980 • 338 citations

Epigenetic changes in colorectal cancer

2003 • 335 citations

BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study.

2000 • 322 citations

Role of DNA methylation in the regulation of transcription

1994 • 318 citations

Association of Breast Cancer DNA Methylation Profiles with Hormone Receptor Status and Response to Tamoxifen

2004 • 308 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function

1993 • 304 citations

CpG-Island Methylation in Aging and Cancer

2000 • 302 citations

Molecular pathology of endometrial hyperplasia and carcinoma

2001 • 301 citations

Ras Uses the Novel Tumor Suppressor RASSF1 as an Effector to Mediate Apoptosis

2000 • 295 citations

Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.

2000 • 291 citations

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.

2001 • 286 citations

Predicting aberrant CpG island methylation

2003 • 283 citations

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms

2003 • 265 citations

Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats2

1976 • 264 citations

Epigenetic lesions causing genetic lesions in human cancer

2000 • 256 citations

Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors.

1996 • 253 citations

Incidence of Invasive Breast Cancer by Hormone Receptor Status From 1992 to 1998

2002 • 247 citations

Estrogen, progesterone and epithelial ovarian cancer.

2003 • 244 citations

A comparison of transcriptional activation by ERα and ERβ

1999 • 239 citations

Abnormalities of the APC/β-catenin pathway in endometrial cancer

2002 • 236 citations

Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism.

1991 • 234 citations

Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.

2003 • 229 citations

Quantitative Assessment of Promoter Hypermethylation during Breast Cancer Development

2002 • 221 citations

Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma and peritoneal fluid from ovarian cancer patients

2005 • 220 citations

Colorectal Cancer With Mutation in BRAF, KRAS, and Wild-Type With Respect to Both Oncogenes Showing Different Patterns of DNA Methylation

2004 • 218 citations

Primary Ovarian Carcinomas Display Multiple Methylator Phenotypes Involving Known Tumor Suppressor Genes

2001 • 204 citations

Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability

2001 • 195 citations

The effect of cholecystectomy on bile salt metabolism

1973 • 195 citations

Role of APC and DNA mismatch repair genes in the development of colorectal cancers.

2003 • 192 citations

Loss of Estrogen Receptor Signaling Triggers Epigenetic Silencing of Downstream Targets in Breast Cancer

2004 • 185 citations

Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors

1997 • 184 citations

Methylation Silencing and Mutations of the p14ARF and p16INK4a Genes in Colon Cancer

2001 • 181 citations

Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.

2000 • 170 citations

ER Inhibits Proliferation and Invasion of Breast Cancer Cells

2001 • 168 citations

Detection of Breast Cancer in Nipple Aspirate Fluid by CpG Island Hypermethylation

2004 • 167 citations

Hypermethylation of the CpG island of theRASSF1A gene in ovarian and renal cell carcinomas

2001 • 160 citations

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.

1995 • 160 citations

Non-small cell lung cancer-derived soluble mediators and prostaglandin E2 enhance peripheral blood lymphocyte IL-10 transcription and protein production.

1996 • 160 citations

A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines.

2004 • 150 citations

Prevention of cancers of the breast, endometrium and ovary

2004 • 148 citations

Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers

2001 • 147 citations

Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia

2004 • 146 citations

Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer.

2001 • 146 citations

Bile acid secretion and biliary bile acid composition altered by cholecystectomy

1973 • 145 citations

Nonrandom Distribution of Aberrant Promoter Methylation of Cancer-Related Genes in Sporadic Breast Tumors

2004 • 141 citations

Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors

2006 • 137 citations

Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.

1988 • 134 citations

Abnormalities of E‐ and P‐cadherin and catenin (β‐, γ‐catenin, and p120^ctn) expression in endometrial cancer and endometrial atypical hyperplasia

2003 • 133 citations

Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor.

1987 • 129 citations

Phytoestrogens and Vitamin D Metabolism: A New Concept for the Prevention and Therapy of Colorectal, Prostate, and Mammary Carcinomas

2004 • 126 citations

Adjuvant chemotherapy plus tamoxifen compared with tamoxifen alone for postmenopausal breast cancer: meta-analysis of quality-adjusted survival

1996 • 119 citations

Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women.

2002 • 119 citations

Methylation of the RASSF1A Gene in Human Cancers

2002 • 119 citations

Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer.

1999 • 118 citations

Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor.

1988 • 117 citations

BRCA1 expression is not directly responsive to estrogen

1997 • 116 citations

Hypermethylation in Histologically Distinct Classes of Breast Cancer

2004 • 114 citations

Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene

2004 • 113 citations

Somatic Mutations of the APC Gene in Primary Breast Cancers

2000 • 111 citations

A case-control study of large bowel cancer and hormone exposure in women.

1989 • 109 citations

Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture

1997 • 105 citations

Estrogens, BRCA1, and breast cancer.

2000 • 105 citations

Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms

2003 • 103 citations

Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma.

2003 • 100 citations

A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer.

1999 • 99 citations

Increased Risk of Colorectal Cancer After Cholecystectomy

1981 • 97 citations

p14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53

2003 • 97 citations

Cell division is required for de novo methylation of CpG islands in bladder cancer cells.

2002 • 97 citations

Involvement of Estrogen Receptor β in Ovarian Carcinogenesis

2004 • 93 citations

Relationship between cholecystectomy and ascending colon cancer

1980 • 92 citations

Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer.

2002 • 91 citations

Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability

2002 • 89 citations

Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors

2003 • 86 citations

The ras signaling pathway in mammary tumorigenesis and metastasis.

2001 • 83 citations

Modifying chromatin to permit steroid hormone receptor-dependent transcription

2003 • 81 citations

Methylation of p16 in primary gynecologic malignancy

1999 • 79 citations

Hormone replacement therapy and improved survival among postmenopausal women diagnosed with colon cancer (USA).

1999 • 78 citations

The influence of parity and exogenous female hormones on the risk of colorectal cancer

1989 • 76 citations

Transcriptional regulation by the estrogen receptor of antioxidative stress enzymes and its functional implications

2003 • 74 citations

Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells

1998 • 74 citations

Cell type-specific methylation of an intronic CpG island controls expression of the MCJ gene

2003 • 70 citations

Hormones and Hormone Antagonists: Mechanisms of Action in Carcinogenesis of Endometrial and Breast Cancer

2001 • 70 citations

Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy

2004 • 66 citations

Differential Expression of Progesterone Receptor Isoforms A and B in the Normal Ovary, and in Benign, Borderline, and Malignant Ovarian Tumors

2002 • 64 citations

Cytosine-phosphoguanine methylation of estrogen receptors in endometrial cancer.

2001 • 62 citations

Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype.

2002 • 60 citations

Female gender is a major determinant of changing subsite distribution of colorectal cancer with age

1985 • 59 citations

Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time.

2001 • 56 citations

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high‐frequency microsatellite instability

2001 • 55 citations

Metabolic Epidemiology of Colon Cancer

2015 • 53 citations

Hypermethylation‐associated transcriptional silencing of E‐cadherin in primary sporadic colorectal carcinomas

2002 • 52 citations

Hormone replacement therapy in relation to survival in women diagnosed with colon cancer

2003 • 51 citations

Analysis of genetic and epigenetic processes that influence p14ARF expression in breast cancer

2001 • 49 citations

DNA REPAIR AND COLORECTAL CANCER

1996 • 49 citations

Microsatellite instability in hereditary and sporadic breast cancers

2003 • 48 citations

Frequency of extra-colonic tumors in hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) Brazilian families: An analysis by a Brazilian Hereditary Colorectal Cancer Institutional Registry

2002 • 45 citations

Age and sex differences in right colon cancer

1986 • 43 citations

Differences inp16Gene Methylation and Expression in Benign and Malignant Ovarian Tumors

1999 • 40 citations

Suppression of gap junctional intercellular communication via 5' CpG island methylation in promoter region of E-cadherin gene in endometrial cancer cells

2003 • 39 citations

APC, beta-catenin, and E-cadherin and the development of recurrent endometrial carcinoma

2004 • 38 citations

CDKN2A gene inactivation in epithelial sporadic ovarian cancer

1999 • 38 citations

Endometrial cancer. Management of high risk and recurrence including the tamoxifen controversy

1995 • 37 citations

Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.

1994 • 37 citations

Cholecystectomy and the Risk of Colon Cancer

1999 • 36 citations

Effect of Reproductive Hormones on Ovarian Epithelial Tumors: I. Effect

2002 • 36 citations

Loss of estrogen receptor (ER) expression in endometrial tumors is not associated with de novo methylation of the 5' end of the ER gene.

2000 • 24 citations

Differences in loss of p16INK4 protein expression by promoter methylation between left- and right-sided primary colorectal carcinomas

2003 • 22 citations

Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines

2002 • 22 citations

Inactivation of p16^INK4a by CpG hypermethylation is not a frequent event in colorectal cancer

2003 • 21 citations

Aberrant DNA Methylation: Have We Entered the Era of More Than One Type of Colorectal Cancer?

2003 • 14 citations

The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma

2004 • 8 citations