Association of Breast Cancer DNA Methylation Profiles with Hormone Receptor Status and Response to Tamoxifen

Molecular portraits of human breast tumours

2000 • 15,445 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Finding Groups in Data

1990 • 6,558 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

Tamoxifen for early breast cancer: an overview of the randomised trials

1998 • 4,082 citations

The power and the promise of DNA methylation markers

2003 • 1,544 citations

MethyLight: a high-throughput assay to measure DNA methylation

2000 • 1,382 citations

The Lifetime Risk of Developing Breast Cancer

1993 • 928 citations

Tamoxifen: a most unlikely pioneering medicine

2003 • 754 citations

Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

2003 • 716 citations

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

2001 • 695 citations

The DNA methylation paradox

1999 • 642 citations

DNA methylation and breast carcinogenesis

2002 • 452 citations

Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer.

1984 • 385 citations

Tumour class prediction and discovery by microarray-based DNA methylation analysis

2002 • 288 citations

Minireview: Genomic Organization of the Human ERα Gene Promoter Region

2001 • 255 citations

Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene.

1991 • 238 citations

Metabolism of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes: Formation of the 4-Hydroxy, 4′-Hydroxy andN-Desmethyl Metabolites and Isomerization oftrans-4-Hydroxytamoxifen

2002 • 236 citations

Quantitative Assessment of Promoter Hypermethylation during Breast Cancer Development

2002 • 221 citations

DNA methylation in breast cancer.

2001 • 210 citations

Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein Levels in MCF-7 Cells by Estradiol: Analysis of Estrogen’s Effect on Progesterone Receptor Synthesis and Degradation*

1988 • 192 citations

Molecular and pharmacological aspects of antiestrogen resistance

2001 • 134 citations

ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers

2003 • 102 citations

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor–deficient mice

2001 • 98 citations

Estrogenic and antiestrogenic activities of 16α- and 2-hydroxy metabolites of 17β-estradiol in MCF-7 and T47D human breast cancer cells

1998 • 92 citations

Anti-oestrogenic prevention of breast cancer — the make or break point

2002 • 49 citations

Down regulation of Bc12 expression in invasive ductal carcinomas is both estrogen- and progesterone-receptor dependent and associated with poor prognostic factors

2002 • 33 citations

On the diagnosis and treatment of breast cancer

1979 • 19 citations