Methylation of p16 in primary gynecologic malignancy

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

DNA methylation and cancer

1994 • 418 citations

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia.

1997 • 150 citations

p16/MTS1 inactivation in ovarian carcinomas: High frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors

1998 • 71 citations

p16andp15Alterations in Primary Gynecologic Malignancy

1997 • 44 citations

Rare mutations and no hypermethylation at theCDKN2A locus in epithelial ovarian tumours

1997 • 39 citations

Absence of deletions but frequent loss of expression of p16INK4 in human ovarian tumours

1997 • 36 citations

No Evidence Exists for Methylation Inactivation of thep16Tumor Suppressor Gene in Ovarian Carcinogenesis

1998 • 18 citations

Expression of p16INK4 and Rb Genes in Cervical Neoplasm

1997 • 4 citations