Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Source of Estrogen Production in Postmenopausal Women1

1973 • 961 citations

The Formation of Estrogens by Central Neuroendocrine Tissues

1975 • 794 citations

Utilization of Oxygen and Reduced Nicotinamide Adenine Dinucleotide Phosphate by Human Placental Microsomes during Aromatization of Androstenedione

1974 • 693 citations

Plasma Precursors of Estrogen. II. Correlation of the Extent of Conversion of Plasma Androstenedione to Estrone with Age¹

1974 • 436 citations

Distribution and Regulation of Aromatase Activity in the Rat Hypothalamus and Limbic System*

1985 • 416 citations

Aromatization of Androstenedione by Human Adipose Tissue Stromal Cells in Monolayer Culture*

1981 • 395 citations

Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis.

1993 • 361 citations

Nonsteroidal Antiinflammatory Drugs and Breast Cancer

1996 • 352 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

1993 • 337 citations

Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis

1989 • 323 citations

Aromatization of Androgens by Human Abdominal and Breast Fat Tissue1

1975 • 311 citations

Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.

1993 • 303 citations

The importance of local synthesis of estrogen within the breast

1987 • 280 citations

Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

1991 • 257 citations

Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.

1996 • 250 citations

CONCENTRATION OF OESTROGENS AND ANDROGENS IN HUMAN OVARIAN VENOUS PLASMA AND FOLLICULAR FLUID THROUGHOUT THE MENSTRUAL CYCLE

1976 • 235 citations

Aromatase P450 Gene Expression in Human Adipose Tissue. ROLE OF A Jak/STAT PATHWAY IN REGULATION OF THE ADIPOSE-SPECIFIC PROMOTER

1995 • 229 citations

Aromatase activity in adipose tissue from breast quadrants: a link with tumour site

1988 • 213 citations

Effect of obesity on conversion of plasma androstenedione to estrone in ovulatory and anovulatory young women

1978 • 202 citations

Aromatase activity and interleukin-6 production by normal and malignant breast tissues.

1995 • 193 citations

Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta

1991 • 178 citations

Competitive reverse transcription-polymerase chain reaction analysis indicates that levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age.

1994 • 177 citations

Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids.

1981 • 174 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription [published erratum appears in J Clin Endocrinol Metab 1994 Feb;78(2):494]

1993 • 172 citations

Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators

1995 • 157 citations

Cellular Localization of Rat Testicular Aromatase Activity during Development

1985 • 154 citations

Immunohistochemical Localization of Aromatase Cytochrome P-450 and Estradiol Dehydrogenase in the Syncytiotrophoblast of the Human Placenta*

1987 • 147 citations

Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells.

1993 • 146 citations

Structural characterization of the human estrogen synthetase (aromatase) gene

1990 • 143 citations

Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes.

1995 • 139 citations

Structural and functional characterization of human aromatase P‐450 gene

1990 • 133 citations

Expression of Messenger Ribonucleic Acid Species Encoding Steroidogenic Enzymes in Human Follicles and Corpora Lutea throughout the Menstrual Cycle*

1990 • 126 citations

Presence of alternatively spliced transcripts of aromatase gene in human breast cancer.

1996 • 109 citations

The Endocrine function of the human ovary

1976 • 99 citations

Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues.

1994 • 95 citations

Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification

1992 • 93 citations

Regulation of estrogen biosynthesis in human adipose stromal cells. Effects of dibutyryl cyclic AMP, epidermal growth factor, and phorbol esters on the synthesis of aromatase cytochrome P-450.

1987 • 93 citations

Growth Factors Suppress and Phorbol Esters Potentiate the Action of Dibutyryl Adenosine 3′,5′-Monophosphate to Stimulate Aromatase Activity of Human Adipose Stromal Cells*

1986 • 93 citations

Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes

1995 • 85 citations

Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification.

1992 • 73 citations

Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues

1994 • 70 citations

The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture.

1994 • 70 citations

Acute stimulation of aromatization in Leydig cells by human chorionic gonadotropin in vitro.

1979 • 64 citations

Alternative promotion of aromatase P-450 expression in the human placenta

1992 • 64 citations

Molecular cloning of a cDNA showing alternative splicing of the 5′‐untranslated sequence of mRNA for human aromatase P‐450

1993 • 54 citations

Biological activities of 17-phenyl-18,19,20-trinorprostaglandins

1975 • 45 citations

Factors Affecting the Conversion of Androstenedione to Estrogens by Human Fetal Hepatocytes in Monolayer Culture*

1985 • 40 citations

6-Keto-prostaglandin E1 is more potent than prostaglandin I2 as a renal vasodilator and renin secretagogue.

1981 • 37 citations

Aromatase in human fetal tissues

1989 • 35 citations

Regulation of aromatase activity of cultured adipose stromal cells by catecholamines and adrenocorticotropin

1984 • 34 citations

Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR

1995 • 34 citations

Aromatase activity in adipose tissue from breast quadrants

1989 • 32 citations

Neutral fats and cancer.

1981 • 30 citations

Potentiation of Epinephrine-Induced Lipolysis by Catechol Estrogens and Their Methoxy Derivatives*

1981 • 27 citations

Inhibition of Prostaglandin Biosynthesis in Human Adipose Tissue by Glucocorticosteroids*

1983 • 23 citations

Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids

1974 • 17 citations

Version, its indications and contraindications

1925 • 7 citations