Mechanisms of Estrogen Action

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

1998 • 4,127 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

1998 • 2,473 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 • 1,680 citations

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

1997 • 1,655 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.

1995 • 1,354 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Sequence and Expression of Human Estrogen Receptor Complementary DNA

1986 • 1,321 citations

Evidence of Estrogen Receptors in Normal Human Osteoblast-Like Cells

1988 • 1,246 citations

Regulation of Transcription by a Protein Methyltransferase

1999 • 1,169 citations

Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency

1997 • 1,157 citations

Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1

1997 • 1,098 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

1996 • 992 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

1999 • 963 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Structure and specificity of nuclear receptor–coactivator interactions

1998 • 922 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

A role for oestrogens in the male reproductive system

1997 • 872 citations

Identification of a new class of steroid hormone receptors

1988 • 845 citations

Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

1988 • 836 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.

1996 • 827 citations

Orphan Nuclear Receptors: From Gene to Function*

1999 • 789 citations

Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

1998 • 776 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Skeletal Effects of Estrogen*

1994 • 722 citations

Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses

1997 • 710 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

1998 • 685 citations

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1998 • 667 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

1995 • 665 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Estrogen Stimulates Gene Expression and Protein Production of Osteoprotegerin in Human Osteoblastic Cells*

1999 • 657 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

The vascular protective effects of estrogen

1996 • 642 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

1999 • 637 citations

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

1999 • 630 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

Dissociation between steroid receptor expression and cell proliferation in the human breast.

1997 • 623 citations

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

1996 • 621 citations

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

1998 • 609 citations

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

1995 • 599 citations

Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene

1999 • 595 citations

Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

1999 • 584 citations

Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

1999 • 583 citations

Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors

1998 • 580 citations

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

1991 • 577 citations

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1991 • 576 citations

Association of bone mineral density with polymorphism of the estrogen receptor gene

1996 • 567 citations

Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor

1997 • 543 citations

Soybean Isoflavones Improve Cardiovascular Risk Factors without Affecting the Reproductive System of Peripubertal Rhesus Monkeys

1996 • 542 citations

Chromatin disruption and modification

1999 • 537 citations

An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors

1996 • 535 citations

Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

1995 • 532 citations

Advances in Bone Biology: The Osteoclast*

1996 • 522 citations

The Complete Primary Structure of Human Estrogen Receptor β (hERβ) and Its Heterodimerization with ER αin Vivoandin Vitro

1998 • 510 citations

Cloning and Characterization of Human Estrogen Receptor β Isoforms

1998 • 508 citations

Estrogen receptor (ER) β, a modulator of ERα in the uterus

2000 • 504 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor.

1992 • 486 citations

Fundamentally Different Logic of Gene Regulation in Eukaryotes and Prokaryotes

1999 • 472 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

1999 • 460 citations

Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human

1998 • 452 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

1999 • 449 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors

1998 • 444 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

1993 • 442 citations

A role for estrogen receptor β in the regulation of growth of the ventral prostate

2001 • 438 citations

The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine Systems

1998 • 431 citations

Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene.

1995 • 428 citations

Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

1999 • 421 citations

The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

1998 • 421 citations

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β

1997 • 414 citations

Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERβ–/– mice

1999 • 412 citations

Osteoclast Differentiation Factor Acts as a Multifunctional Regulator in Murine Osteoclast Differentiation and Function

1999 • 412 citations

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β

1999 • 405 citations

Functional Synergy between the Transcription Factor Sp1 and the Estrogen Receptor

1997 • 399 citations

p300 is a component of an estrogen receptor coactivator complex.

1996 • 399 citations

A novel protein complex that interacts with the vitamin D₃ receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

1998 • 391 citations

Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†

1997 • 386 citations

The estrogen receptor locus is associated with a major gene influencing litter size in pigs.

1996 • 381 citations

Peptide Antagonists of the Human Estrogen Receptor

1999 • 372 citations

The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions

1999 • 369 citations

Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins

1998 • 366 citations

Expression of oestrogen receptor beta (ER beta) in multiple rat tissues visualised by immunohistochemistry

1997 • 364 citations

Steroid hormone receptors and their regulation by phosphorylation

1996 • 361 citations

Dietary Genistein Exerts Estrogenic Effects upon the Uterus, Mammary Gland and the Hypothalamic/Pituitary Axis in Rats

1997 • 361 citations

The Orphan Nuclear Receptor Estrogen-Related Receptor α Is a Transcriptional Regulator of the Human Medium-Chain Acyl Coenzyme A Dehydrogenase Gene

1997 • 360 citations

Purification and Identification of p68 RNA Helicase Acting as a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor α

1999 • 359 citations

Estrogen receptors α and β in the rodent mammary gland

2000 • 357 citations

Pattern of distribution of cells positive for estrogen receptor α and progesterone receptor in relation to proliferating cells in the mammary gland

1999 • 356 citations

Ligand-independent activation of steroid hormone receptors

1998 • 349 citations

pp90^rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

1998 • 348 citations

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1998 • 337 citations

Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1

1998 • 337 citations

Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

1995 • 334 citations

Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha , but not by ERbeta

1999 • 331 citations

Tissue Distribution of Estrogen Receptors Alpha (ER-α) and Beta (ER-β) mRNA in the Midgestational Human Fetus

1997 • 329 citations

FOLLOW-UP STUDY OF MALE AND FEMALE OFFSPRING OF DES-EXPOSED MOTHERS

1977 • 316 citations

Identification of Estrogen Receptor β2, A Functional Variant of Estrogen Receptor β Expressed in Normal Rat Tissues

1998 • 313 citations

Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β*

1999 • 312 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

1997 • 306 citations

Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor.

1996 • 305 citations

Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice

1991 • 304 citations

Expression of Estrogen Receptor β in Rat Bone

1997 • 295 citations

An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens

1999 • 295 citations

Hormone-independent Transcriptional Activation and Coactivator Binding by Novel Orphan Nuclear Receptor ERR3

1999 • 295 citations

Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF- B site

1997 • 291 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

1991 • 289 citations

Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane

1998 • 285 citations

Comparative distribution of estrogen receptor-α (ER-α) and β (ER-β) mRNA in the rat pituitary, gonad, and reproductive tract

1998 • 280 citations

Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract.

1998 • 277 citations

Cancer Incidence in a Population Accidentally Exposed to 2,3,7,8-Tetrachlorodibenzo-para-dioxin

1993 • 270 citations

In utero exposure to diethylstilbestrol: Adverse effects on the reproductive tract and reproductive performance in male and female offspring

1982 • 268 citations

Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras¹

1998 • 267 citations

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

1998 • 265 citations

Immunolocalisation of oestrogen receptor-α within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood

1997 • 263 citations

Multiple Signal Input and Output Domains of the 160-Kilodalton Nuclear Receptor Coactivator Proteins

1999 • 262 citations

The Seveso studies on early and long-term effects of dioxin exposure: a review.

1998 • 262 citations

Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development

1999 • 260 citations

Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator.

1996 • 258 citations

Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization

1999 • 254 citations

Permanent Effects of Neonatal Estrogen Exposure in Rats on Reproductive Hormone Levels, Sertoli Cell Number, and the Efficiency of Spermatogenesis in Adulthood1

1999 • 254 citations

Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors α and β

1999 • 254 citations

A Transcriptional Coactivator, Steroid Receptor Coactivator-3, Selectively Augments Steroid Receptor Transcriptional Activity

1998 • 251 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Fertility in Men Exposed Prenatally to Diethylstilbestrol

1995 • 247 citations

Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone.

1993 • 246 citations

17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA

1992 • 242 citations

A comparison of transcriptional activation by ERα and ERβ

1999 • 239 citations

Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats

1990 • 238 citations

Estrogen Receptor Expression in Prostate Cancer and Premalignant Prostatic Lesions

1999 • 237 citations

Ontogeny of Estrogen Receptor-β Expression in Rat Testis**This work was supported by grants from the Swedish Medical Research Council (MFR K98–04P-12596–01A) and the Loo och Hans Ostermans Stiftelse (to G.G.J.M.K.) and a grant from the European Union (EU-PL95–1223; to B.v.d.B., P.T.v.d.S., and J.-Å.G.).

1999 • 227 citations

Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol.

1996 • 225 citations

A Regulatory Role for RIP140 in Nuclear Receptor Activation

1998 • 222 citations

SMRTER, a Drosophila Nuclear Receptor Coregulator, Reveals that EcR-Mediated Repression Is Critical for Development

1999 • 216 citations

Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants.

1997 • 216 citations

AF-2 Activity and Recruitment of Steroid Receptor Coactivator 1 to the Estrogen Receptor Depend on a Lysine Residue Conserved in Nuclear Receptors

1997 • 214 citations

Different Regions in Activation Function-1 of the Human Estrogen Receptor Required for Antiestrogen- and Estradiol-dependent Transcription Activation

1996 • 214 citations

Selective Estrogen Receptor Modulators: Clinical Spectrum*

1999 • 213 citations

SAP30, a Component of the mSin3 Corepressor Complex Involved in N-CoR-Mediated Repression by Specific Transcription Factors

1998 • 212 citations

Estradiol-induced Phosphorylation of Serine 118 in the Estrogen Receptor Is Independent of p42/p44 Mitogen-activated Protein Kinase

1998 • 212 citations

A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors in Vivo

1999 • 210 citations

Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor.

1995 • 209 citations

Sources of oestrogen in the testis and reproductive tract of the male

1999 • 208 citations

Molecular Mechanism of Inhibition of Estrogen-Induced Cathepsin D Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in MCF-7 Cells

1995 • 205 citations

Effect of the estrogen receptor locus on reproduction and production traits in four commercial pig lines.

1997 • 203 citations

Potentiation of Human Estrogen Receptor α Transcriptional Activation through Phosphorylation of Serines 104 and 106 by the Cyclin A-CDK2 Complex

1999 • 200 citations

Estrogen-related Receptor, hERR1, Modulates Estrogen Receptor-mediated Response of Human Lactoferrin Gene Promoter

1996 • 200 citations

Estrogen Receptor Expression in Developing Epididymis, Efferent Ductules, and Other Male Reproductive Organs*

1991 • 199 citations

Remembrance of things PAS: regulation of development by bHLH–PAS proteins

1999 • 198 citations

The potential roles of estrogens in regulating Leydig cell development and function: A review

1999 • 196 citations

The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

1994 • 196 citations

CBP/p300 Functions as a Possible Transcriptional Coactivator of Ah Receptor Nuclear Translocator (Arnt)

1997 • 194 citations

Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol.

1994 • 192 citations

Estrogen Receptor (α and β) Expression in the Excurrent Ducts of the Adult Male Rat Reproductive Tract

1997 • 190 citations

Estrogen-Induced c-fos Protooncogene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor Sp1 Complex Formation*

1998 • 190 citations

Abnormalities in Functional Development of the Sertoli Cells in Rats Treated Neonatally with Diethylstilbestrol: A Possible Role for Estrogens in Sertoli Cell Development1

1998 • 189 citations

Biochemical Alterations in Sex Hormone-Induced Hyperplasia and Dysplasia of the Dorsolateral Prostates of Noble Rats

1988 • 187 citations

Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats.

1990 • 186 citations

The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen.

1995 • 185 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats

1987 • 184 citations

Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.

1995 • 183 citations

Regulation of Cathepsin-D and pS2 Gene Expression by Growth Factors in MCF7 Human Breast Cancer Cells

1989 • 180 citations

The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ

1999 • 179 citations

Serum oestradiol and oestrogen‐receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males

1998 • 178 citations

Oestrogen receptor (ESR) polymorphisms and breast cancer susceptibility

1994 • 177 citations

P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

1999 • 177 citations

Identification and Characterization of a Novel Functional Estrogen Receptor on Human Sperm Membrane That Interferes with Progesterone Effects

1999 • 171 citations

Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: Analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression

1997 • 170 citations

Expression and Localization of Estrogen Receptor-β in Murine and Human Bone

1999 • 169 citations

Neonatal Estrogen Exposure Up-Regulates Estrogen Receptor Expression in the Developing and Adult Rat Prostate Lobes*

1997 • 169 citations

Amplification and overexpression of peroxisome proliferatoractivated receptor binding protein ( PBP/PPARBP ) gene in breast cancer

1999 • 168 citations

Molecular Determinants of the Estrogen Receptor-Coactivator Interface

1999 • 167 citations

Nuclear Receptors Have Distinct Affinities for Coactivators: Characterization by Fluorescence Resonance Energy Transfer

1998 • 166 citations

The quinone reductase gene: A unique estrogen receptor-regulated gene that is activated by antiestrogens

1997 • 166 citations

Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.

1994 • 165 citations

Estrogen regulation of cell cycle progression in breast cancer cells

1998 • 163 citations

Estrogen Receptor-β Messenger Ribonucleic Acid Ontogeny in the Prostate of Normal and Neonatally Estrogenized Rats*

1998 • 163 citations

Cooperative Interaction between AhR·Arnt and Sp1 for the Drug-inducible Expression of CYP1A1 Gene

1996 • 160 citations

Differential Recruitment of Coactivator RIP140 byAh and Estrogen Receptors

1999 • 158 citations

The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors

2000 • 157 citations

Identification of a splice variant of the rat estrogen receptor β gene

1997 • 156 citations

Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth

1998 • 156 citations

Skeletal response of ovariectomized rats to low and high doses of 17β-estradiol

1991 • 156 citations

The TAFs in the HAT

1998 • 155 citations

Aromatase Inhibition Impairs Skeletal Modeling and Decreases Bone Mineral Density in Growing Male Rats*

1997 • 153 citations

Two Separate Mechanisms for Ligand-Independent Activation of the Estrogen Receptor

1997 • 153 citations

Interactions of Nuclear Receptor Coactivator/Corepressor Proteins with the Aryl Hydrocarbon Receptor Complex

1999 • 151 citations

A Role for Estrogen-related Receptor α in the Control of Mitochondrial Fatty Acid β-Oxidation during Brown Adipocyte Differentiation

1997 • 149 citations

Estrogen receptor gene polymorphism and bone mineral density at the lumbar spine of pre- and postmenopausal women

1997 • 149 citations

Estrogen hits the surface

1999 • 149 citations

Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary.

1995 • 147 citations

Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses

1996 • 143 citations

Remodeling the estrogen receptor model

1984 • 142 citations

Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.

1996 • 141 citations

Teratogen update: Carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero

1995 • 141 citations

Growth Factor Synthesis and Human Breast Cancer Progression

1995 • 140 citations

Expression of estrogen receptor alpha and beta during mouse embryogenesis

1999 • 140 citations

Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor.

1995 • 139 citations

The ERR-1 Orphan Receptor Is a Transcriptional Activator Expressed During Bone Development

1997 • 139 citations

Estradiol Regulation of Insulin-Like Growth Factor-I Expression in Osteoblastic Cells: Evidence for Transcriptional Control

1991 • 138 citations

Developmental estrogenization and prostatic neoplasia

1994 • 137 citations

Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis

1996 • 137 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

1992 • 137 citations

A Novel Isoform of Rat Estrogen Receptor Beta with 18 Amino Acid Insertion in the Ligand Binding Domain as a Putative Dominant Negative Regulator of Estrogen Action

1998 • 137 citations

Phosphorylation of Tyrosine 537 on the Human Estrogen Receptor Is Required for Binding to an Estrogen Response Element

1995 • 137 citations

Cloning and Characterization of RAP250, a Novel Nuclear Receptor Coactivator

2000 • 137 citations

Estrogen Receptor Subtype-Selective Ligands: Asymmetric Synthesis and Biological Evaluation of cis- and trans-5,11-Dialkyl- 5,6,11,12-tetrahydrochrysenes

1999 • 137 citations

Specific modulation of estrogen receptor mRNA isoforms in rat pituitary throughout the estrous cycle and in response to steroid hormones

1997 • 136 citations

Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3.

1994 • 136 citations

Isolation of a Gene Encoding a Novel Member of the Nuclear Receptor Superfamily from the Critical Region of Usher Syndrome Type IIa at 1q41

1998 • 136 citations

Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.

1984 • 134 citations

Novel Receptor Interaction and Repression Domains in the Orphan Receptor SHP

1997 • 133 citations

Localization of Estrogen Receptor-α in Human and Rabbit Skeletal Tissues

1998 • 132 citations

RIP-140 Interacts with Multiple Nuclear Receptors by Means of Two Distinct Sites

1996 • 132 citations

Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA binding.

1992 • 132 citations

Functional Analysis of a Novel Estrogen Receptor-β Isoform

1999 • 131 citations

The estrogen receptor family

1999 • 128 citations

Demonstration of Estrogen Receptor-β Immunoreactivity in Human Growth Plate Cartilage

1999 • 128 citations

Coactivator Peptides Have a Differential Stabilizing Effect on the Binding of Estrogens and Antiestrogens with the Estrogen Receptor

1999 • 125 citations

Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced pS2 expression.

1994 • 124 citations

Transcriptional Activities of the Orphan Nuclear Receptor ERRα (Estrogen Receptor-Related Receptor-α)

1999 • 124 citations

Molecular Cloning of an Estrogen Receptor β Subtype from the Goldfish,Carassius auratus

1999 • 122 citations

Phosphorylation on Tyrosine ofin VitroSynthesized Human Estrogen Receptor Activates Its Hormone Binding

1989 • 122 citations

Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17β-Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes*

1999 • 121 citations

Genistein exerts estrogen-like effects in male mouse reproductive tract

1998 • 120 citations

Ligand-independent Activation of Steroid Receptors: New Roles for Old Players

1999 • 119 citations

Modulating nuclear receptor function: may the phos be with you

1999 • 119 citations

Estrogen receptor mutations in breast cancer

1993 • 119 citations

Estrogen-Induced Retinoic Acid Receptor α1 Gene Expression: Role of Estrogen Receptor-Sp1 Complex

1998 • 118 citations

Transcription and Translation of Estrogen Receptor-β in the Male Reproductive Tract of Estrogen Receptor-α Knock-Out and Wild-Type Mice¹

1998 • 117 citations

Estrogen receptor in the rat uterus. Physiological forms and artifacts

1972 • 117 citations

Estrogen-induced alterations in the autonomic responses of the rabbit urinary bladder.

1980 • 114 citations

Crosstalk between estrogen receptor α and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes

2000 • 113 citations

Developmental Regulation of Murine Mammary Progesterone Receptor Gene Expression*

1990 • 113 citations

The unliganded estrogen receptor (ER) transduces growth factor signals

1994 • 113 citations

Transcriptional Activation of c-fos Protooncogene by 17β-Estradiol: Mechanism of Aryl Hydrocarbon Receptor-Mediated Inhibition

1999 • 113 citations

Possible linkage of the estrogen receptor gene to breast cancer in a family with late-onset disease.

1991 • 112 citations

Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer

1990 • 111 citations

A Novel Role for Helix 12 of Retinoid X Receptor in Regulating Repression

1999 • 110 citations

Immunoexpression of Aquaporin-1 in the Efferent Ducts of the Rat and Marmoset Monkey during Development, Its Modulation by Estrogens, and Its Possible Role in Fluid Resorption*

1998 • 110 citations

Preliminary in situ identification of estrogen target cells in bone

1995 • 110 citations

Different positioning of the ligand-binding domain helix 12and the F domain of the estrogen receptor accounts for functional differences between agonists and antagonists

1998 • 109 citations

Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.

1996 • 109 citations

Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: Consequence on DNA binding

1995 • 109 citations

Estradiol receptor: phosphorylation on tyrosine in uterus and interaction with anti-phosphotyrosine antibody.

1986 • 109 citations

Mechanistic Principles in NR Box-Dependent Interaction between Nuclear Hormone Receptors and the Coactivator TIF2

1998 • 109 citations

Activation of the osteopontin promoter by the orphan nuclear receptor estrogen receptor related alpha.

1998 • 108 citations

Osteoclasts isolated from membranous bone in children exhibit nuclear estrogen and progesterone receptors

1990 • 107 citations

Estrogen Receptor-α Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression

1998 • 107 citations

Estrogen Receptor β Activates the Human Retinoic Acid Receptorα -1 Promoter in Response to Tamoxifen and Other Estrogen Receptor Antagonists, but Not in Response to Estrogen

1999 • 106 citations

Estradiol-Binding Mechanism and Binding Capacity of the Human Estrogen Receptor Is Regulated by Tyrosine Phosphorylation

1997 • 104 citations

SV40 early-to-late switch involves titration of cellular transcriptional repressors.

1993 • 103 citations

Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis

1997 • 103 citations

Interactive effects of estradiol and 2,3,7,8-tetrachloro-dibenzo-p-dioxin on hepatic cytochrome P-450 and mouse uterus

1986 • 101 citations

Dietary phytoestrogens and their role in hormonally dependent disease

1998 • 100 citations

Expression of the estrogen-related receptor 1 (ERR-1) orphan receptor during mouse development

1997 • 97 citations

Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex

1997 • 95 citations

The putative nuclear receptor mediator TIF1α is tightly associated with euchromatin

1999 • 95 citations

Therapeutic potential of selective estrogen receptor modulators

1998 • 95 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells

1990 • 93 citations

Estrogen and Prolactin Regulation of Rat Dorsal and Lateral Prostate in Organ Culture*

1991 • 91 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells.

1990 • 90 citations

An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors

1999 • 90 citations

Properties of a purified estradiol-dependent calf uterus tyrosine kinase

1993 • 89 citations

Disproportional Body Growth in Female Estrogen Receptor-α-Inactivated Mice

1999 • 89 citations

Alterations of maternal estrogen levels during gestation affect the skeleton of female offspring.

1996 • 89 citations

Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors

1999 • 88 citations

Males Exposed In Utero to Diethylstilbestrol

1984 • 87 citations

A PCR Analysis of ERα and ERβ mRNA Abundance in Rats and the Effect of Ovariectomy

1999 • 87 citations

Transcriptional suppression of estrogen receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1998 • 85 citations

Sperm, a source of estrogen.

1995 • 84 citations

Immunocytochemical Localization of Estrogen Receptors in the Normal Male and Female Canine Urinary Tract and Prostate*

1987 • 84 citations

Cross-coupling between insulin and estrogen receptor in human neuroblastoma cells.

1996 • 84 citations

Multiple splicing variants of the estrogen receptor are present in individual human breast tumors

1996 • 83 citations

Estrogen receptor variant and hypertension in women.

1993 • 83 citations

PROSTATE GLAND GROWTH DURING DEVELOPMENT IS STIMULATED IN BOTH MALE AND FEMALE RAT FETUSES BY INTRAUTERINE PROXIMITY TO FEMALE FETUSES

1999 • 83 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17β-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression

1990 • 82 citations

Mice, Estrogen, and Postmenopausal Osteoporosis

1999 • 82 citations

Molecular cloning and characterization of Japanese eel estrogen receptor cDNA

1996 • 81 citations

Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction

1997 • 80 citations

Increased expression of fibroblast growth factor 8 in human breast cancer

1999 • 80 citations

Functional Interactions between the Estrogen Receptor and the Transcription Activator Sp1 Regulate the Estrogen-dependent Transcriptional Activity of the Vitellogenin A1 ioPromoter

1997 • 79 citations

Prostatic Dysplasia Associated With Increased Expression of C-Myc in Neonatally Estrogenized Mice

1993 • 77 citations

Competition between Thyroid Hormone Receptor-associated Protein (TRAP) 220 and Transcriptional Intermediary Factor (TIF) 2 for Binding to Nuclear Receptors

1999 • 76 citations

Characterization of membrane estrogen binding proteins from rabbit uterus

1999 • 74 citations

Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse hepa 1c1c7 cells

1991 • 73 citations

The Effects of Estradiol, Tamoxifen, and Testosterone on the Weights and Histology of the Epididymis and Accessory Sex Organs of Sexually Immature Rabbits^*

1983 • 72 citations

Activation of the thyroid hormone receptor α gene promoter by the orphan nuclear receptor ERRα

1998 • 72 citations

Divergent Pathways Regulate Ligand-Independent Activation of ERα in SK-N-BE Neuroblastoma and COS-1 Renal Carcinoma Cells

1998 • 71 citations

Oestradiol stimulates tyrosine phosphorylation and hormone binding activity of its own receptor in a cell-free system.

1987 • 70 citations

The mouse estrogen receptor-related orphan receptor alpha 1: molecular cloning and estrogen responsiveness

1997 • 69 citations

Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium

1999 • 68 citations

Genetic mutations resulting in estrogen insufficiency in the male

1998 • 67 citations

Expression of estrogen receptor-alpha in cells of the osteoclastic lineage

1999 • 66 citations

Cellular distribution of estrogen receptor β in neonatal rat bone

2000 • 66 citations

In vivo and in vitro phosphorylation of the human estrogen receptor

1995 • 66 citations

Characterization of ligand-dependent phosphorylation of the estrogen receptor.

1994 • 65 citations

Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3',5'-monophosphate and ligands including antiestrogens.

1994 • 65 citations

Proton NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements

1990 • 65 citations

Quantitative Analysis of Estrogen Receptor Proteins in Rat Mammary Gland*

2001 • 65 citations

The Putative Cofactor TIF1α Is a Protein Kinase That Is Hyperphosphorylated upon Interaction with Liganded Nuclear Receptors

1998 • 65 citations

Rapid effects of estrogen and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder

1999 • 65 citations

Neonatal Estrogen Stimulates Proliferation of Periductal Fibroblasts and Alters the Extracellular Matrix Composition in the Rat Prostate**This work was supported by NIH grant DK-40890 (to G.S.P.) and the Research Funds of the Department of Veterans Affairs (to M.J.W.).

1999 • 64 citations

Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists

1994 • 63 citations

Induction of cytochrome P-450IA1, IA2, IIB1, IIB2 and IIE1 by broccoli in rat liver and colon

1991 • 62 citations

Inhibition of postconfluent focus production in cultures of MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 62 citations

DNA synthesis in the canine prostate: Effects of androgen and estrogen treatment

1987 • 61 citations

Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen-activated protein kinase-independent pathway.

1998 • 61 citations

Cellular Localization of Estrogen Receptor Beta Messenger Ribonucleic Acid in Cynomolgus Monkey Reproductive Organs

1999 • 59 citations

Molecular Cloning of Estrogen Receptors α and β in the Ovary of A Teleost Fish, the Tilapia (Oreochromis niloticus)

1999 • 58 citations

Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR

1999 • 58 citations

The pathophysiological role of estrogen receptor variants in human breast cancer

1998 • 57 citations

Age-related changes in human oestrogen receptor α function and levels in osteoblasts

1998 • 56 citations

Identification of a Functional Imperfect Estrogen-Responsive Element in the 5‘-Promoter Region of the Human Cathepsin D Gene

1997 • 56 citations

Inhibition of the 17β-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus

1991 • 54 citations

The Human Estrogen Receptor Structural Gene Contains a DNA Sequence That Binds Activated Mouse and Human Ah Receptors: A Possible Mechanism of Estrogen Receptor Regulation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1993 • 52 citations

The aryl hydrocarbon receptor interacts with transcription factor IIB.

1998 • 52 citations

Neonatal exposure of male rats to estradiol benzoate causes rete testis dilation and backflow impairment of spermatogenesis

1998 • 52 citations

Neurotransmitters activate the human estrogen receptor in a neuroblastoma cell line

1997 • 51 citations

Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain in complex with DNA and free in solution

1995 • 51 citations

Immunofluorescent localization of estrogen receptor-α in growth plates of rabbits, but not in rats, at sexual maturity

1999 • 50 citations

Morphometric Study of the Gubernaculum in Male Estrogen Receptor Mutant Mice

1996 • 49 citations

Sex Steroids as a Cause of Adenocarcinoma of the Dorsal Prostate in Nb Rats, and their Influence on the Growth of Transplants

1977 • 48 citations

Neonatal Estrogen Exposure Alters the Transforming Growth Factor-β Signaling System in the Developing Rat Prostate and Blocks the Transient p21cip1/waf1 Expression Associated with Epithelial Differentiation*

1999 • 46 citations

Organization of a rainbow trout estrogen receptor gene

1993 • 45 citations

Simian virus 40 late gene expression is regulated by members of the steroid/thyroid hormone receptor superfamily.

1995 • 45 citations

Estrogen and progesterone receptor mRNA are expressed in distinct pattern in male primate reproductive organs

1995 • 45 citations

Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activation

1997 • 44 citations

The first contiguous estrogen receptor gene from a fish, Oreochromis aureus: evidence for multiple transcripts

1996 • 42 citations

Identification of phosphorylation sites in the mouse oestrogen receptor

1995 • 38 citations

Increases in Blood Flow of the Female Rabbit Urethra Following Low Dose Estrogens

1986 • 38 citations

Detection of estrogen receptor alpha, carbonic anhydrase II and tartrate-resistant acid phosphatase mRNAs in putative mononuclear osteoclast precursor cells of neonatal rats by fluorescence in situ hybridization

1998 • 38 citations

The one-to-four rule and paralogues of sex-determining genes

1999 • 37 citations

Oncogenes and tumour suppressor genes in first trimester human fetal gonadal development

1999 • 36 citations

The Nonresponsiveness of Lactating Mammary Gland to Estradiol*

1982 • 36 citations

Genomic cross-talk between the estrogen receptor and growth factor regulatory pathways in estrogen target tissues.

1994 • 35 citations

Chromosomal Mapping of the Human and Murine Orphan Receptors ERRα (ESRRA) and ERRβ (ESRRB) and Identification of a Novel Human ERRα-Related Pseudogene

1997 • 34 citations

Neonatal Estrogenization of the Male Mouse Results in Urethral Dysfunction

1996 • 34 citations

Inhibition of Prolactin Receptor Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in MCF-7 Human Breast Cancer Cells

1996 • 33 citations

Neonatal estrogenization of the male mouse results in urethral dysfunction.

1996 • 33 citations

Comparison of Urinary Bladder Function in Sexually Mature and Immature Male and Female Rats

1990 • 32 citations

Determinants for the repression of estrogen receptor transcriptional activity by ligand-occupied progestin receptors

1997 • 32 citations

Incidence of an estrogen receptor polymorphism in breast cancer patients

1991 • 31 citations

Estrogen Receptors in the Human Male Bladder, Prostatic Urethra, and Prostate

1995 • 31 citations

Chromatin remodeling regulated by steroid and nuclear receptors

1997 • 31 citations

Morphometric studies of neonatal estrogen imprinting in the mature mouse prostate

1999 • 30 citations

Differential Regulation of Carbonic Anhydrase II by Androgen and Estrogen in Dorsal and Lateral Prostate of the Rat*

1991 • 29 citations

Interaction of male and female sex hormones in cultured rat prostate

1987 • 28 citations

Neonatal exposure to diethylstilbestrol permanently alters the basal and 17β-estradiol induced expression of c-fos proto-oncogene in mouse urethroprostatic complex

1997 • 28 citations

Association of an Estrogen Receptor Variant with Increased Height in Women

1994 • 28 citations

Nature of Metaplasia in Rat Coagulating Glands Induced by Neonatal Treatment with Estrogen

1970 • 26 citations

Modulation of mouse estrogen receptor transcription activity by protein kinase C delta

1998 • 25 citations

Combined effects of testosterone and estradiol on rat ventral prostate in organ culture.

1978 • 24 citations

Estrogen receptor mutations

1998 • 24 citations

Structure and function of the DNA-binding domain of the glucocorticoid receptor and other members of the nuclear receptor supergene family

1993 • 23 citations

The biology of breast cancer

1994 • 22 citations

Relationships Between Prostaglandins and Estrogens on the Motility of Isolated Rings From the Rat Urinary Bladder

1983 • 22 citations

The selective oestrogen receptor modulation: evolution and clinical applications

1999 • 22 citations

Phosphorylation on tyrosine of oestradiol-17β receptor in uterus and interaction of oestradiol-17β and glucocorticoid receptors with antiphosphotyrosine antibodies

1987 • 20 citations

Selective oestrogen receptor modulators: potential therapeutic applications

1998 • 18 citations

Estrogen Stimulates the Elaboration of Cell/Matrix Surface-Associated Inhibitory Factor of Osteoclastic Bone Resorption from Osteoblastic Cells

1993 • 17 citations

Influence of Estradiol on Accessory Reproductive Organs in the Castrated Male Rat Effects of Bromocriptine and Flutamide

1983 • 14 citations

Autoradiographic demonstration of binding sites for oestradiol and dihydrotestosterone in the urinary tract of male and female baboons

1983 • 14 citations

Women’s Health in the Next Millennium: Endocrinology Is Leading the Way

1999 • 2 citations