CDKN2A gene inactivation in epithelial sporadic ovarian cancer

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

1996 • 251 citations

Human epithelial ovarian cancer allelotype.

1993 • 241 citations

Allele-Specific Loss in Chromosome 9p Loci in Preneoplastic Lesions Accompanying Non-Small-Cell Lung Cancers

1995 • 211 citations

Hypermethylation of the p16 gene in nasopharyngeal carcinoma.

1996 • 193 citations

Cyclin E, a redundant cyclin in breast cancer

1996 • 121 citations

Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer

1996 • 121 citations

Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2.

1995 • 95 citations

Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis

1997 • 89 citations

Patterns of allelic loss on chromosome 17 in sporadic breast carcinomas detected by fluorescent-labeled microsatellite analysis

1997 • 83 citations

p16/MTS1 inactivation in ovarian carcinomas: High frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors

1998 • 71 citations

P 16 Overexpression: A potential early indicator of transformation in ovarian carcinoma

1997 • 65 citations

Automated fluorescent analysis procedure for enzymatic mutation detection

1998 • 63 citations

High frequency of chromosome 9 deletion in ovarian cancer: evidence for three tumour-suppressor loci

1996 • 50 citations

Alteration ofp16 andp15 genes in common epithelial ovarian tumors

1997 • 48 citations

Alterations of the p16 (MTS1) Gene in Testicular, Ovarian, and Endometrial Malignancies

1995 • 41 citations

Rare mutations and no hypermethylation at theCDKN2A locus in epithelial ovarian tumours

1997 • 39 citations

Loss of heterozygosity on chromosome 9 in human breast cancer: Association with clinical variables and genetic changes at other chromosome regions

1995 • 39 citations

Loh and mutation analysis of CDKN2 in primary human ovarian cancers

1995 • 35 citations

ERBB2 gene amplification detected by fluorescent differential polymerase chain reaction in paraffin‐embedded breast carcinoma tissues

1995 • 32 citations

Expression Analyses of Epidermal Growth Factor Receptor and HER-2/neu: No Advantage of Prediction of Recurrence or Survival in Breast Cancer Patients

1996 • 28 citations

Homozygous deletions on the short arm of chromosome 9 in ovarian adenocarcinoma cell lines and loss of heterozygosity in sporadic tumors.

1994 • 26 citations

Oncogene amplification in archival ovarian carcinoma detected by fluorescent differential polymerase chain reaction - a routine analytical approach

1996 • 7 citations