Epigenetics in human disease and prospects for epigenetic therapy

The language of covalent histone modifications

2000 • 8,260 citations

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

1999 • 4,776 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

The history of cancer epigenetics

2004 • 2,270 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

2002 • 2,040 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

The power and the promise of DNA methylation markers

2003 • 1,544 citations

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

2002 • 1,485 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

2003 • 1,356 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase

2002 • 1,213 citations

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

2003 • 1,212 citations

Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin

2003 • 1,199 citations

ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

2003 • 1,041 citations

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

2003 • 1,035 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

2001 • 997 citations

The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation

2003 • 960 citations

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

2000 • 960 citations

Establishment and Maintenance of a Heterochromatin Domain

2002 • 895 citations

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

2002 • 864 citations

The many faces of histone lysine methylation

2002 • 819 citations

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies

2003 • 796 citations

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

2003 • 740 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

2001 • 687 citations

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.

1994 • 667 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

Binary switches and modification cassettes in histone biology and beyond

2003 • 628 citations

The SWI/SNF complex — chromatin and cancer

2004 • 589 citations

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

2003 • 541 citations

Inhibition of DNA Methylation and Reactivation of Silenced Genes by Zebularine

2003 • 523 citations

DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis

2002 • 489 citations

Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.

2000 • 487 citations

Interplay between Two Epigenetic Marks

2002 • 475 citations

Germline epimutation of MLH1 in individuals with multiple cancers

2004 • 470 citations

Imprinting in Prader–Willi and Angelman syndromes

1998 • 451 citations

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

2003 • 420 citations

Linking the epigenetic ‘language’ of covalent histone modifications to cancer

2004 • 385 citations

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

2002 • 383 citations

Prader-Willi syndrome: advances in genetics, pathophysiology and treatment

2003 • 383 citations

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

2002 • 343 citations

Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma

2002 • 338 citations

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment

1977 • 335 citations

Histone deacetylases

2003 • 327 citations

Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.

2003 • 307 citations

CpG-Island Methylation in Aging and Cancer

2000 • 302 citations

Beckwith-Wiedemann syndrome: imprinting in clusters revisited

2000 • 299 citations

An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation

2002 • 298 citations

Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin

2003 • 297 citations

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

2003 • 294 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.

2003 • 283 citations

Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease

2003 • 273 citations

Reactivating the expression of methylation silenced genes in human cancer

2002 • 265 citations

5-Azacytidine, a new, highly effective cancerostatic

1964 • 261 citations

A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor.

2002 • 244 citations

Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation

2001 • 236 citations

Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2'-deoxycytidine

2001 • 227 citations

RNA and the Epigenetic Regulation of X Chromosome Inactivation

1998 • 227 citations

Molecular-clinical spectrum of the ATR-X syndrome

2000 • 225 citations

Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine.

2002 • 208 citations

Epigenetic targets in hematopoietic malignancies

2003 • 207 citations

Mutagenicity of 5-aza-2′-deoxycytidine is mediated by the mammalian DNA methyltransferase

1997 • 207 citations

Role of DNA Methylation in the Regulation of Cell Function: Autoimmunity, Aging and Cancer

2002 • 203 citations

The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease

2003 • 191 citations

Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.

2001 • 180 citations

Activation of the p53 DNA Damage Response Pathway after Inhibition of DNA Methyltransferase by 5-Aza-2′-deoxycytidine

2001 • 174 citations

Studies of X chromosome DNA methylation in normal human cells

1982 • 157 citations

DNA Methylation and Histone Deacetylation in the Control of Gene Expression: Basic Biochemistry to Human Development and Disease

2001 • 150 citations

Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate.

1984 • 146 citations

Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells

1999 • 132 citations

Specific Inhibition of DNMT1 by Antisense Oligonucleotides Induces Re-expression of Estrogen Receptor a (ER) in ER-negative Human Breast Cancer Cell Lines

2003 • 92 citations

p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding.

2003 • 89 citations

Syndromes of disordered chromatin remodeling

2003 • 89 citations

Antisense RNA in imprinting: spreading silence through Air

2002 • 86 citations

DiFferential Nuclear Protein Binding to 5-Azacytosine-Containing DNA as a Potential Mechanism for 5-Aza-2′-Deoxycytidine Resistance

1987 • 75 citations

Comment on "Chromosomal Instability and Tumors Promoted by DNA Hypomethylation" and "Induction of Tumors in Mice by Genomic Hypomethylation"

2003 • 74 citations

A Rheostat Model for a Rapid and Reversible Form of Imprinting-Dependent Evolution

2002 • 70 citations

Activation of an imprinted Igf 2 gene in mouse somatic cell cultures.

1993 • 61 citations

Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer

2004 • 56 citations

Carcinogenicity and haemoglobin synthesis induction by cytidine analogues

1988 • 53 citations

Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance.

1987 • 49 citations

Chromatin Modification, Leukaemia and Implications for Therapy

2002 • 47 citations

β-adrenergic receptor induction in HeLa cells: Synergistic effect of 5-azacytidine and butyrate

1982 • 33 citations

The X chromosome and fragile X mental retardation

2002 • 23 citations