DNA REPAIR AND COLORECTAL CANCER

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1991 • 2,142 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

The Molecular Basis of Turcot's Syndrome

1995 • 1,116 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1996 • 957 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

1984 • 743 citations

The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

1989 • 728 citations

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1994 • 622 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.

1996 • 576 citations

DNA Mismatch Correction in a Defined System

1989 • 551 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

1995 • 521 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

1994 • 495 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

1995 • 403 citations

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.

1995 • 391 citations

Genetic instability occurs in the majority of young patients with colorectal cancer

1995 • 378 citations

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

1994 • 366 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

Better survival rates in patients with MLH1-associated hereditary colorectal cancer

1996 • 362 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

Founding mutations and Alu-mediated recombination in hereditary colon cancer

1995 • 308 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

Structure of the Human MSH2 Locus and Analysis of Two Muir-Torre Kindreds for msh2 Mutations

1994 • 287 citations

Microsatellite instability in inherited and sporadic neoplasms

1995 • 257 citations

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

1992 • 253 citations

Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria

1986 • 252 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

1992 • 221 citations

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

1995 • 219 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

Mitotic Crossovers between Diverged Sequences Are Regulated by Mismatch Repair Proteins in Saccharomyces cerevisiae

1996 • 212 citations

Methyl-directed mismatch repair is bidirectional

1993 • 208 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae.

1995 • 201 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

1992 • 173 citations

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas

1995 • 171 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein

1994 • 166 citations

Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC)

1995 • 165 citations

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.

1995 • 160 citations

Bidirectional excision in methyl-directed mismatch repair

1993 • 153 citations

One role for DNA methylation in vertebrate cells is strand discrimination in mismatch repair.

1985 • 148 citations

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.

1995 • 147 citations

Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.

1994 • 143 citations

The yeast gene MSH3 defines a new class of eukaryotic MutS homologues

1993 • 140 citations

Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer families.

1995 • 133 citations

Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

1984 • 127 citations

Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.

1995 • 125 citations

DNA Loop Repair by Human Cell Extracts

1994 • 125 citations

Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16.

1996 • 121 citations

Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria.

1986 • 112 citations

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions.

1995 • 106 citations

GATC sequences, DNA nicks and the MutH function in Escherichia coli mismatch repair.

1987 • 101 citations

Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients

1994 • 96 citations

Colon cancer and DNA repair: have mismatches met their match?

1994 • 90 citations

The role of heteroduplex correction in gene conversion in Saccharomyces cerevisiae

1987 • 86 citations

Detection of new mutations in six out of 10 Swiss HNPCC families by genomic sequencing of the hMSH2 and hMLH1 genes.

1995 • 72 citations

In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer

1995 • 69 citations

CpG dinucleotides in the hMSH2 and hMLHI genes are hotspots for HNPCC mutations

1996 • 61 citations

Monoallelic mutation analysis (MAMA) for identifying germline mutations

1995 • 56 citations

Mismatch repair, genetic stability and tumour avoidance

1995 • 51 citations

Alternative splicing of MLH1 messenger RNA in human normal cells.

1995 • 50 citations

A truncated hMSH2 transcript occurs as a common variant in the population: implications for genetic diagnosis.

1996 • 43 citations

Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development.

1994 • 37 citations

The microsatellite mutator phenotype of colon cancer cells is often recessive.

1995 • 34 citations