APC, beta-catenin, and E-cadherin and the development of recurrent endometrial carcinoma

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

β-catenin signaling and cancer

1999 • 867 citations

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1999 • 738 citations

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

2001 • 532 citations

E-cadherin binding prevents β-catenin nuclear localization and β-catenin/LEF-1-mediated transactivation

1999 • 526 citations

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

2000 • 522 citations

The APC gene in colorectal cancer

2002 • 432 citations

Wnt/β-catenin signaling

2000 • 421 citations

Beta-catenin mutation in carcinoma of the uterine endometrium.

1998 • 370 citations

Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability

2002 • 323 citations

Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.

1999 • 261 citations

E-cadherin and alpha-catenin expression in human esophageal cancer.

1994 • 253 citations

Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.

2001 • 245 citations

Abnormalities of the APC/β-catenin pathway in endometrial cancer

2002 • 236 citations

Catenins, Wnt signaling and cancer

2000 • 227 citations

Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast

2001 • 226 citations

β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas

1999 • 225 citations

Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia

2000 • 174 citations

Aging, cancer and nutrition: the DNA methylation connection

2003 • 168 citations

A New Rapid Immunohistochemical Staining Technique Using the EnVision Antibody Complex

2001 • 156 citations

Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.

2001 • 151 citations

E-cadherin and its associated protein catenins, cancer invasion and metastasis

1996 • 142 citations

Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors.

1997 • 141 citations

Methylation and colorectal cancer

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Abnormalities of E‐ and P‐cadherin and catenin (β‐, γ‐catenin, and p120^ctn) expression in endometrial cancer and endometrial atypical hyperplasia

2003 • 133 citations

New gynecologic cancer staging.

1990 • 133 citations

Methylation of hMLH1 in a population-based series of endometrial carcinomas.

2000 • 124 citations

Loss of E‐cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance

2002 • 124 citations

Nuclear localization of beta-catenin in normal and carcinogenic endometrium.

1999 • 120 citations

E-cadherin downregulation in cancer: fuel on the fire?

1999 • 115 citations

Decreased E-Cadherin Expression in Endometrial Carcinoma Is Associated with Tumor Dedifferentiation and Deep Myometrial Invasion

1994 • 109 citations

Decreased expression of catenins (? and ?), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas

2001 • 109 citations

Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus

1996 • 106 citations

Mutational Analysis of the CTNNB1 and APC Genes in Uterine Endometrioid Carcinoma

2000 • 105 citations

Mutations of the β‐Catenin Gene in Endometrial Carcinomas

1999 • 99 citations

Frequent hypermethylation of the 5' CpG island of E-cadherin in esophageal adenocarcinoma.

2001 • 95 citations

Novel germlineCDH1mutations in hereditary diffuse gastric cancer families

2002 • 65 citations

CpG methylation of promoter region inactivates E‐cadherin gene in renal cell carcinoma

2001 • 63 citations

Hypermethylation in promoter region of E‐cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma

2003 • 61 citations

Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype.

2002 • 60 citations

Decreased E-cadherin augments β-catenin nuclear localization: Studies in breast cancer cell lines

2001 • 32 citations

β-Catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis

2002 • 23 citations

A novel immunohistochemical detection system using mirror image complementary antibodies (MICA)

1999 • 22 citations

Catenins, Wnt signaling and cancer

2000 • 21 citations

E-cadherin promoter methylation can regulate its expression in invasive ductal breast cancer tissue in Chinese woman

2002 • 19 citations

Expressions of E-cadherin and alpha- and beta-catenin mRNAs in uterine endometrial cancers.

1998 • 16 citations

Nuclear localization of β‐catenin in normal and carcinogenic endometrium

1999 • 3 citations