DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

de la Chapelle, A.

1997 • 3,184 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

2000 • 1,182 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

1998 • 1,173 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

2001 • 923 citations

The ABC of APC

2001 • 853 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

2000 • 522 citations

Deficient DNA mismatch repair: a common etiologic factor for colon cancer

2001 • 505 citations

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer

1996 • 451 citations

Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer

2000 • 446 citations

Methylation of the BRCA1 gene in sporadic breast cancer.

1997 • 384 citations

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

1994 • 329 citations

Genetic and Epigenetic Modification of MLH1 Accounts for a Major Share of Microsatellite-Unstable Colorectal Cancers

2000 • 286 citations

Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

1998 • 260 citations

Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.

1997 • 217 citations

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

2000 • 182 citations

High allele loss rates at I7q I2‐q2I in breast and ovarian tumors from BRCAI‐linked families

1995 • 122 citations

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers

2000 • 114 citations

Rapid quantification of DNA methylation by high performance capillary electrophoresis

2000 • 111 citations

Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers

1997 • 102 citations

'Other' breast cancer susceptibility genes: searching for more holy grail

2001 • 97 citations

Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer

1997 • 85 citations

Molecular analysis of the BRCA1 and BRCA2 genes in 32 breast and/or ovarian cancer Spanish families

2000 • 82 citations

Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents.

2000 • 81 citations

DNA methylation learns to fly

2001 • 79 citations

Peutz-Jeghers Syndrome: Molecular Analysis of a Three-Generation Kindred With a Novel Defect in the Serine Threonine Kinase Gene STK11

1999 • 33 citations

Predominant germ-line mutation of thehMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds

1999 • 26 citations