Molecular pathology of endometrial hyperplasia and carcinoma

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Two pathogenetic types of endometrial carcinoma

1983 • 2,309 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer

2000 • 1,352 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 690 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer

1999 • 665 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 589 citations

Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.

1999 • 530 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

PTEN/MMAC1 mutations in endometrial cancers.

1997 • 517 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

The frequency of p53, k-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma

2000 • 453 citations

Beta-catenin mutation in carcinoma of the uterine endometrium.

1998 • 370 citations

p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis.

1997 • 350 citations

Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.

1998 • 350 citations

p53 in endometrial cancer and its putative precursors: Evidence for diverse pathways of tumorigenesis

1995 • 341 citations

hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis

1999 • 310 citations

Endometrial intraepithelial carcinoma: A distinctive lesion specifically associated with tumors displaying serous differentiation

1995 • 302 citations

Association between CpG island methylation and microsatellite instability in colorectal cancer.

1997 • 295 citations

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma

2000 • 290 citations

PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.

1998 • 286 citations

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.

1998 • 270 citations

Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.

1999 • 261 citations

Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.

1999 • 233 citations

Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.

1998 • 228 citations

Microsatellite instability in endometrial carcinoma.

1994 • 228 citations

Causes and consequences of microsatellite instability in endometrial carcinoma.

1999 • 217 citations

Uterine papillary serous carcinoma: A study on 108 cases with emphasis on the prognostic significance of associated endometrioid carcinoma, absence of invasion, and concomitant ovarian carcinoma

1992 • 209 citations

Microsatellite Instability in Sporadic Endometrial Carcinoma

1994 • 191 citations

Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma.

1996 • 185 citations

Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers.

1995 • 181 citations

Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.

1993 • 176 citations

THE INTERACTIONS OF APC, E-CADHERIN AND β-CATENIN IN TUMOUR DEVELOPMENT AND PROGRESSION

1997 • 171 citations

PTEN mutations in endometrial carcinomas: A molecular and clinicopathologic analysis of 38 cases

2000 • 169 citations

K-ras activation in premalignant and malignant epithelial lesions of the human uterus.

1991 • 163 citations

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.

1995 • 160 citations

The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.

1997 • 158 citations

Microsatellite instability in endometrial carcinomas: clinicopathologic correlations in a series of 42 cases

1998 • 153 citations

Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas.

1997 • 149 citations

Allelic profiles of mononucleotide repeat microsatellites in control individuals and in colorectal tumors with and without replication errors

1997 • 143 citations

CTNNB1 mutations and β-catenin expression in endometrial carcinomas

2002 • 138 citations

p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.

2001 • 135 citations

Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium.

1993 • 131 citations

A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses.

1997 • 131 citations

K-ras activation in neoplasms of the human female reproductive tract.

1990 • 130 citations

Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency

1999 • 127 citations

Clinical significance of microsatellite instability in endometrial carcinoma

2000 • 122 citations

Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis.

2000 • 119 citations

K-ras mutations in endometrial carcinomas with microsatellite instability

2001 • 117 citations

The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium.

1998 • 111 citations

Mutational analysis ofMLH1 andMSH2 in 25 prospectively-acquired RER+ endometrial cancers

1997 • 106 citations

Mutational Analysis of the CTNNB1 and APC Genes in Uterine Endometrioid Carcinoma

2000 • 105 citations

Microsatellite instability in endometrial carcinomas: Frequent replication errors in tumors of early onset and/or of poorly differentiated type

1995 • 103 citations

Molecular Mechanisms Underlying Hereditary Nonpolyposis Colorectal Carcinoma

1996 • 100 citations

Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.

1998 • 99 citations

Mutations of the β‐Catenin Gene in Endometrial Carcinomas

1999 • 99 citations

CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

1999 • 92 citations

Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma.

1994 • 90 citations

Allelotype of uterine cancer by analysis of RFLP and microsatellite polymorphisms: Frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p

1994 • 89 citations

Carcinogenesis and Natural Selection: A New Perspective to the Genetics and Epigenetics of Colorectal Cancer

1999 • 82 citations

Mutations of the Ki-ras oncogene in carcinoma of the endometrium.

1995 • 82 citations

Mutations of the Ki-ras oncogene in endometrial carcinoma

1992 • 68 citations

Microsatellite Instability and Expression of MLH1 and MSH2 in Normal and Malignant Endometrial and Ovarian Epithelium in Hereditary Nonpolyposis Colorectal Cancer Family Members

1999 • 67 citations

β- And γ-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability

2001 • 56 citations

K-rasPoint Mutations in Endometrial Carcinoma: Effect on Outcome Is Dependent on Age of Patient

1996 • 55 citations

Deletion mapping on chromosome 10q25-q26 in human endometrial cancer

1996 • 52 citations

Loss of heterozygosity in usual and special variant carcinomas of the endometrium

1997 • 50 citations

Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinoma with microsatellite instability

2000 • 49 citations

Differences in patterns ofTP53 andKRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability

1999 • 48 citations

Studies on Ras Oncogene Activation in Endometrial Carcinoma

1993 • 48 citations

The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer

1997 • 47 citations

BAX somatic frameshift mutations in endometrioid adenocarcinomas of the endometrium: evidence for a tumor progression role in endometrial carcinomas with microsatellite instability.

1998 • 47 citations

Microsatellite Instability and Somatic Mutations in Endometrial Carcinomas

1998 • 33 citations

A somaticBRCA2 mutation in RER+ endometrial carcinomas that specifically deletes the amino-terminal transactivation domain

1999 • 27 citations

Frequent Occurrence of c-Ki-ras Gene Mutations in Well Differentiated Endometrial Adenocarcinoma Showing Infiltrative Local Growth with Fibrosing Stromal Response

1995 • 25 citations

Loss of estrogen receptor (ER) expression in endometrial tumors is not associated with de novo methylation of the 5' end of the ER gene.

2000 • 24 citations

A novel sensitive method to detect frameshift mutations in exonic repeat sequences of cancer-related genes

1999 • 17 citations

Mutations of the Estrogen Receptor in Endometrial Carcinoma: Evidence of an Association with High Tumor Grade

1996 • 17 citations

Deleted Work

1955 • 0 citations