COX-2 is expressed in human pulmonary, colonic, and mammary tumors

TNM Classification of Malignant Tumors

1998 • 5,989 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

1998 • 933 citations

Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.

1998 • 825 citations

Expression of cyclooxygenase-2 in human lung carcinoma.

1998 • 729 citations

Regulation of the immune response by prostaglandins

1983 • 717 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in Human Breast Cancer

1998 • 665 citations

Incidence of and Treatment for Ductal Carcinoma In Situ of the Breast

1996 • 600 citations

Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

1995 • 565 citations

Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production.

1998 • 498 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

TNM Classification of Malignant Tumors.5th ed

1998 • 455 citations

Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.

1996 • 426 citations

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

1996 • 421 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 • 413 citations

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

1995 • 400 citations

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

1994 • 377 citations

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

1997 • 362 citations

PGE2 and Angiogenesis

1983 • 341 citations

Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition

1999 • 334 citations

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

1997 • 326 citations

Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.

1987 • 305 citations

Aspirin and reduced risk of esophageal carcinoma

1995 • 290 citations

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

1996 • 281 citations

Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer

1993 • 276 citations

Cyclooxygenase-2 gene expression in human breast cancer

1997 • 274 citations

Differential expression and regulation of cyclooxygenase-1 and -2 in two human breast cancer cell lines.

1996 • 244 citations

Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells.

1994 • 154 citations

The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis

1998 • 142 citations

Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy

1999 • 123 citations

Ackerman's Surgical Pathology

1997 • 119 citations

Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis.

1998 • 117 citations

Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats.

1996 • 117 citations

Antitumoral Activity of Indomethacin on Experimental Esophageal Tumors

1984 • 88 citations

Inhibition of lung tumourigenesis by sulindac: comparison of two experimental protocols

1997 • 87 citations

Effects of NSAIDs on Proliferation of Gastric Cancer Cells In Vitro: Possible Implication of Cyclooxygenase-2 in Cancer Development

1998 • 82 citations

Inhibition of mammary carcinogenesis by flurbiprofen, a non-steroidal antiinflammatory agent

1983 • 77 citations

Further studies on the therapeutic effect of indomethacin on esophageal tumors

1986 • 71 citations

Increased Expression of Cyclooxygenase-2 to -1 in Human Colorectal Cancers and Adenomas, but not in Hyperplastic Polyps

1998 • 69 citations

Delay in hamster buccal pouch carcinogenesis by aspirin and indomethacin

1982 • 62 citations

The role of COX-2 in intestinal cancer

1999 • 59 citations

Why is cyclooxygenase‐2 expressed in neuroendocrine cells of the human alimentary tract?

1997 • 20 citations

Section Review Oncologic, Endocrine & Metabolic: Angiogenesis inhibition as a drug target for disease: an update

1996 • 17 citations

Heterogeneous Distribution of COX-2 Over-Expression in Human Colon Carcinoma Cells

1997 • 4 citations

Deleted Work

1955 • 0 citations