Mitogen-Activated Protein Kinase

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

The insulin signaling system.

1994 • 1,733 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Origin of luteinizing hormone-releasing hormone neurons

1989 • 1,098 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

The Function of Myosin and Myosin Light Chain Kinase Phosphorylation in Smooth Muscle

1985 • 1,052 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

1990 • 959 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules

1991 • 848 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Systemic oxidative stress in asthma, COPD, and smokers.

1996 • 781 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

MAP kinase and cAMP signaling regulate infection structure formation and pathogenic growth in the rice blast fungus Magnaporthe grisea.

1996 • 764 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses

1996 • 728 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

1991 • 708 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules

1991 • 673 citations

Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression.

1988 • 670 citations

The genetic aspects of primary eunuchoidism

1944 • 660 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome

1989 • 612 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.

1996 • 576 citations

Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site

1997 • 574 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

1996 • 504 citations

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

1997 • 504 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

1989 • 494 citations

Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.

1993 • 491 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

1997 • 471 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.

1992 • 464 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1997 • 424 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

1996 • 419 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

1996 • 407 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2.

1994 • 374 citations

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1991 • 369 citations

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

1993 • 369 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

1995 • 356 citations

Glutathione monoethyl ester: Preparation, uptake by tissues, and conversion to glutathione

1985 • 349 citations

Primary Structure of BMK1: A New Mammalian MAP Kinase

1995 • 345 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase

1997 • 332 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs

1995 • 318 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

1996 • 310 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

1992 • 292 citations

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

1993 • 290 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

1995 • 283 citations

Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.

1992 • 281 citations

Complete Nucleotide Sequence of Saccharomyces cerevisiae Chromosome VIII

1994 • 279 citations

mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation Kinetics and Uncoupling from Translation

1995 • 276 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH ₂ -terminal kinase activation, and defects in AP-1 transcriptional activity

1997 • 266 citations

Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27

1995 • 264 citations

Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts.

1996 • 261 citations

A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

1997 • 258 citations

Role of a New Rho Family Member in Cell Migration and Axon Guidance in C. elegans

1997 • 251 citations

A novel putative tyrosine kinase receptor with oncogenic potential.

1991 • 249 citations

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.

1992 • 248 citations

Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils.

1994 • 247 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.

1988 • 240 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Activity of Ubiquitin-dependent Pathway in Response to Oxidative Stress

1997 • 233 citations

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

1997 • 220 citations

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

1994 • 219 citations

Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells.

1994 • 219 citations

Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

1991 • 214 citations

The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.

1984 • 214 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

p493F12 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system

1995 • 206 citations

14-3-3: Modulators of Signaling Proteins?

1994 • 206 citations

Characterization of two cDNAs that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells

1994 • 205 citations

The Fission Yeast pmk1⁺ Gene Encodes a Novel Mitogen-Activated Protein Kinase Homolog Which Regulates Cell Integrity and Functions Coordinately with the Protein Kinase C Pathway

1996 • 204 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

Ectopic Expression of Hel-N1, an RNA-Binding Protein, Increases Glucose Transporter (GLUT1) Expression in 3T3-L1 Adipocytes

1997 • 200 citations

A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants

1991 • 197 citations

The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.

1993 • 197 citations

Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.

1997 • 194 citations

Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade

1996 • 193 citations

Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.

1990 • 190 citations

Regulation of Macrophage Cytokine Production by Prostaglandin E2

1997 • 188 citations

Ontogeny of Gonadotropin-Releasing Hormone-Containing Neurons in Early Fetal Development of Rhesus Macaques*

1990 • 180 citations

The Receptor Tyrosine Kinase ARK Mediates Cell Aggregation by Homophilic Binding

1995 • 179 citations

The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans

1996 • 179 citations

p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties

1997 • 176 citations

Prostaglandin Synthase-1 and Prostaglandin Synthase-2 Are Coupled to Distinct Phospholipases for the Generation of Prostaglandin D2 in Activated Mast Cells

1997 • 175 citations

Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1991 • 175 citations

Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules.

1995 • 172 citations

Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells.

1994 • 166 citations

Phosphorylation of caldesmon in arterial smooth muscle

1989 • 165 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts.

1992 • 164 citations

SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae.

1994 • 164 citations

Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.

1990 • 163 citations

Differential Activation of the Ras/Extracellular-Signal-Regulated Protein Kinase Pathway Is Responsible for the Biological Consequences Induced by the Axl Receptor Tyrosine Kinase

1996 • 162 citations

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

1994 • 158 citations

Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.

1992 • 153 citations

Mast cell tumor necrosis factor α production is regulated by MEK kinases

1997 • 152 citations

An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes.

1994 • 146 citations

Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

1997 • 145 citations

Heterogeneous expression of four MAP kinase isoforms in human tissues

1992 • 143 citations

Molecular mechanisms involved in the regulation of prostaglandin biosynthesis by glucocorticoids

1997 • 141 citations

Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity

1994 • 139 citations

The migration of luteinizing hormone-releasing hormone neurons in the developing rat is associated with a transient, caudal projection of the vomeronasal nerve

1995 • 136 citations

Identification of mitogen‐activated protein kinase phosphorylation sequences in mammalian h‐Caldesmon

1993 • 136 citations

ATMPKs: a gene family of plant MAP kinases in Arabidopsis thaliana

1993 • 135 citations

Activation of Mitogen-Activated Protein Kinase in Porcine Carotid Arteries

1995 • 135 citations

Developmental expression in the mouse nervous system of the p493F12 SAP kinase

1996 • 135 citations

PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation

1993 • 135 citations

GAS6 Mediates Adhesion of Cells Expressing the Receptor Tyrosine Kinase Axl

1997 • 134 citations

Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.

1992 • 133 citations

Phosphatidylinositol 3-Kinase Mediates Epidermal Growth Factor-Induced Activation of the c-Jun N-Terminal Kinase Signaling Pathway

1997 • 133 citations

Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water.

1986 • 133 citations

MsERK1: a mitogen-activated protein kinase from a flowering plant.

1993 • 132 citations

Phosphorylation of smooth muscle caldesmon by mitogen-activated protein (MAP) kinase and expression of MAP kinase in differentiated smooth muscle cells

1992 • 131 citations

Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.

1994 • 130 citations

Angiotensin II stimulates two myelin basic protein/microtubule-associated protein 2 kinases in cultured vascular smooth muscle cells.

1992 • 128 citations

Dynamics of dibutyryl cyclic AMP- and prostaglandin E2-mediated suppression of lipopolysaccharide-induced tumor necrosis factor alpha gene expression

1989 • 126 citations

Effects of local reduction in pressure on distensibility and composition of cerebral arterioles.

1991 • 124 citations

Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system

1996 • 121 citations

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

1993 • 119 citations

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

1992 • 115 citations

Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe

1997 • 114 citations

Cyclic Strain Enhances Adhesion of Monocytes to Endothelial Cells by Increasing Intercellular Adhesion Molecule-1 Expression

1996 • 113 citations

A Subset of Peripherin Positive Olfactory Axons Delineates the Luteinizing Hormone Releasing Hormone Neuronal Migratory Pathway in Developing Mouse

1994 • 112 citations

Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay.

1994 • 109 citations

Thromboxane A2/prostaglandin H2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase.

1994 • 108 citations

The plant homologue of MAP kinase is expressed in a cell cycle‐dependent and organ‐specific manner

1993 • 106 citations

Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.

1994 • 105 citations

[24] Pseudosubstrate-based peptide inhibitors

1991 • 103 citations

A putative receptor tyrosine kinase with unique structural topology.

1991 • 99 citations

Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells.

1993 • 97 citations

Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation

1991 • 96 citations

Expression ofTiam-1in the Developing Brain Suggests a Role for the Tiam-1–Rac Signaling Pathway in Cell Migration and Neurite Outgrowth

1997 • 95 citations

Serum interleukin-10 in human acute pancreatitis.

1997 • 92 citations

Phosphorylation sequences in h‐caldesmon from phorbol ester‐stimulated canine aortas

1992 • 89 citations

Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells

1993 • 89 citations

Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels

1986 • 87 citations

Endothelin-1 and angiotensin-II stimulate delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for common signaling mechanisms.

1994 • 87 citations

Molecular cloning and expression of a MAP kinase homologue from pea

1993 • 86 citations

Efficient selection of recombinant adenoviruses by vectors that express beta-galactosidase

1995 • 84 citations

AVP-induced activation of MAP kinase in vascular smooth muscle cells is mediated through protein kinase C

1993 • 84 citations

Isolation and characterization of a tobacco cDNA clone encoding a putative MAP kinase

1993 • 83 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

Molecular Cloning, Functional Expression in Escherichia coli, and Characterization of Multiple Mitogen‐Activated‐Protein Kinases from Tobacco

1995 • 73 citations

Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.

1993 • 72 citations

Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells.

1995 • 70 citations

Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.

1994 • 69 citations

Extracellular signal-regulated kinases in T cells: Characterization of human ERK1 and ERK2 cDNAs

1992 • 67 citations

MMK2, a novel alfalfa MAP kinase, specifically complements the yeast MPK1 function

1995 • 66 citations

Endothelin-1 stimulates tyrosine phosphorylation and the activities of two mitogen-activated protein kinases in cultured vascular smooth muscle cells

1992 • 64 citations

Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay.

1992 • 63 citations

Identification and Functional Analysis of a Developmentally Regulated Extracellular Signal-Regulated Kinase Gene in Dictyostelium discoideum

1994 • 59 citations

A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function

1997 • 59 citations

A homologue of the MAP/ERK family of protein kinase genes is expressed in vegetative and in female reproductive organs of Petunia hybrida

1995 • 58 citations

Identification of an Activator of the Microtubule‐Associated Protein 2 Kinases ERK1 and ERK2 in PC12 Cells Stimulated with Nerve Growth Factor or Bradykinin

1992 • 57 citations

An Alternative Gonadotropin-releasing Hormone (GnRH) RNA Splicing Product Found in Cultured GnRH Neurons and Mouse Hypothalamus

1997 • 57 citations

Schizosaccharomyces pombe Spk1 is a Tyrosine-Phosphorylated Protein Functionally Related to Xenopus Mitogen-Activated Protein Kinase

1993 • 57 citations

New insights into the control of cell growth; the role of the Axl family

1997 • 56 citations

Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids.

1989 • 56 citations

Characterization of bronchodilator effects and fate of S-nitrosothiols in the isolated perfused and ventilated guinea pig lung.

1995 • 53 citations

Enterocyte differentiation is compatible with SV40 large T expression and loss of p53 function in human colonic Caco‐2 cells

1997 • 53 citations

Mechanisms of signal transduction during alpha 2-adrenergic receptor-mediated contraction of vascular smooth muscle.

1993 • 46 citations

Smooth muscle cell proliferation. Expression and kinase activities of p34cdc2 and mitogen-activated protein kinase homologues.

1993 • 45 citations

Intrahypothalamic injection of a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal of hypogonadism in mutant mice.

1992 • 44 citations

Stimulation of leukotriene production and membrane translocation of 5-lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells

1992 • 43 citations

Activations of mitogen-activated protein kinases and phospholipase D in A7r5 vascular smooth muscle cells.

1994 • 42 citations

Signal Transduction: Switching off MAP kinases

1994 • 40 citations

Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways.

1997 • 38 citations

Intracellular signaling pathways in cardiac myocytes induced by mechanical stress

1994 • 37 citations

Interleukin-3 mRNA Stabilization by a trans-Acting Mechanism in Autocrine Tumors Lacking Interleukin-3 Gene Rearrangements

1995 • 36 citations

Calcium signalling: Sphingosine kinase versus phospholipase C?

1996 • 33 citations

Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1β in mouse cultured mast cells

1996 • 33 citations

Identification and characterization of a nerve growth factor-stimulated mitogen-activated protein kinase activator in PC12 cells.

1993 • 31 citations

The functional effects of mutations Thr⁶⁷³→ Asp and Ser⁷⁰²→ Asp at the Pro‐directed kinase phosophorylation sites in the C‐terminus of chicken gizzard caldesmon

1993 • 30 citations

Cloning and expression of cDNA encoding a mitogen-activated protein kinase from a phytopathogenic filamentous fungus

1997 • 30 citations

Structure and Expression of Carp Mitogen--Activated Protein Kinases Homologous to Mammalian JNK/SAPK

1997 • 28 citations

Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.

1996 • 27 citations

Identification of a major GTP-binding protein in bovine aortic smooth muscle cytosol as the rhoA gene product

1990 • 27 citations

Novel CDC2-related protein kinases produced in murine hematopoietic stem cells

1993 • 26 citations

Smooth-muscle mitogen-activated protein (MAP) kinase: purification and characterization, and the phosphorylation of caldesmon

1993 • 25 citations

Interleukin-11 mRNA Stabilization in Phorbol Ester-Stimulated Primate Bone Marrow Stromal Cells

1996 • 23 citations

<scp>II</scp>. Yeast sequencing reports. An 11·4 kb DNA segment on the left arm of yeast chromosome II carries the carboxypeptidase Y sorting gene PEP1, as well as ACH1, FUS3 and a putative ars

1992 • 23 citations

Regulation of MAP Kinase Activity by Growth Stimuli in Vascular Smooth Muscle

1994 • 22 citations

Characterization of tumorigenic sub-lines from a poorly tumorigenic human colon-adenocarcinoma cell line

1996 • 22 citations

Identification of a major GTP-binding protein in bovine aortic smooth muscle membranes as p21, a GTP-binding protein having the same effector domain as p21s

1989 • 21 citations

Establishment and characterization of a new human colon adenocarcinoma cell line: BCS-TC2

1990 • 19 citations

Sequence of a rat cDNA encoding the ERK1-MAP kinase

1992 • 19 citations

Inhibition of vasopressin action in vascular smooth muscle by the V1 antagonist OPC-21268.

1994 • 15 citations

The porphobilinogen deamise ‐ uroporphyrinogen III cosynthetase system (porphobilinogenase) from bovine liver. Kinetic studies

1969 • 15 citations

Effects of inhibitors of arachidonic acid metabolism on serotonin release from rat basophilic leukemia cells

1993 • 14 citations

The DAC2/FUS3 protein kinase is not essential for transcriptional activation of the mating pheromone response pathway in Saccharomyces cerevisiae

1992 • 11 citations

Sequence Analysis of a 37·6 kbp Cosmid Clone from the Right Arm of Saccharomyces cerevisiae Chromosome XII, Carrying YAP3 , HOG1 , SNR6 , tRNA‐Arg3 and 23 New Open Reading Frames, Among Which Several Homologies to Proteins Involved in Cell Division Control and to Mammalian Growth Factors and other Animal Proteins are Found

1997 • 8 citations

Molecular Analysis of Microtubule-Associated Protein-2 Kinase cDNA from Mouse and Rat Brain

1991 • 8 citations

Sequence Analysis of 203 Kilobases fromSaccharomyces cerevisiae Chromosome VII

1997 • 5 citations