An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Construction of Phylogenetic Trees

1967 • 3,637 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

A Complete Protocol forIn SituHybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes

1989 • 883 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

GABA neurons are the major cell type of the nucleus reticularis thalami

1980 • 667 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Neuronal differentiation in the Drosophila ommatidium

1987 • 532 citations

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

1990 • 521 citations

Steel locus defines new multipotent growth factor

1990 • 509 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

1986 • 478 citations

A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene

1987 • 430 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.

1989 • 413 citations

Genetic dissection of the photoreceptor system in the compound eye of Drosophila melanogaster

1976 • 395 citations

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

1990 • 387 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Genetic analysis of a drosophila neural cell adhesion molecule: Interaction of fasciclin I and abelson tyrosine kinase mutations

1990 • 340 citations

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

1988 • 338 citations

The Drosophila gene torso encodes a putative receptor tyrosine kinase

1989 • 327 citations

Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells.

1990 • 316 citations

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

1988 • 314 citations

SCIP: A glial POU domain gene regulated by cyclic AMP

1989 • 293 citations

Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila

1987 • 279 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation

1988 • 250 citations

cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases

1990 • 234 citations

Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain.

1990 • 228 citations

Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor

1989 • 219 citations

Cell-cell interaction in the drosophila retina: The bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development

1988 • 209 citations

Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.

1988 • 193 citations

c-src gene product in developing rat brain is enriched in nerve growth cone membranes.

1988 • 193 citations

Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain

1988 • 177 citations

The role of cell-cell interaction in the development of the drosophila visual system

1990 • 163 citations

Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo

1990 • 160 citations

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

1990 • 159 citations

Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody.

1988 • 151 citations

Protein tyrosine phosphorylation in synaptic vesicles.

1988 • 148 citations

Cell-specific cyclic AMP-mediated induction of the PDGF receptor.

1990 • 134 citations

Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.

1986 • 131 citations

Regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor at the rat neuromuscular lunction

1990 • 130 citations

Murine c-fms cDNA: cloning, sequence analysis and retroviral expression.

1987 • 113 citations

The structure of the human c-fes/fps proto-oncogene.

1985 • 106 citations

The murine flg gene encodes a receptor for fibroblast growth factor.

1990 • 106 citations

Isolation and sequence analysis of a novel human tyrosine kinase gene.

1989 • 104 citations

Primary sequence and developmental expression of a novel Drosophila melanogaster src gene.

1987 • 98 citations

A Novel Human Gene Closely Related to the abl Proto-Oncogene

1986 • 89 citations

Basic fibroblast growth factor stimulates survival of nonneuronal cells developing from trunk neural crest

1989 • 75 citations

Development of the Drosophila retina: Inductive events studied at single cell resolution

1989 • 71 citations

Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium.

1990 • 69 citations

Regulation of the complex pattern of sevenless expression in the developing Drosophila eye.

1989 • 51 citations

Protein Design and the Development of New Therapeutics and Vaccines

1990 • 48 citations

Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate

1988 • 39 citations