Activity of Ubiquitin-dependent Pathway in Response to Oxidative Stress

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

1983 • 1,105 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

1978 • 622 citations

A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination

1995 • 547 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Hydrogen peroxide and human cataract

1981 • 497 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.

1982 • 413 citations

The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis.

1982 • 324 citations

UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.

1996 • 313 citations

"Covalent affinity" purification of ubiquitin-activating enzyme.

1982 • 310 citations

Oxidative stress on lens and cataract formation: role of light and oxygen

1984 • 305 citations

Ubiquitin as a degradation signal.

1992 • 261 citations

Resistance to cadmium mediated by ubiquitin-dependent proteolysis

1993 • 261 citations

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

1994 • 259 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP.

1979 • 210 citations

Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens

1987 • 196 citations

The protein substrate binding site of the ubiquitin-protein ligase system.

1986 • 178 citations

Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells

1995 • 156 citations

Degradation of G alpha by the N-end rule pathway

1994 • 154 citations

A direct correlation between the levels of ascorbic acid and H2O2 in aqueous humor

1984 • 139 citations

Conjugation of ubiquitin to denatured hemoglobin is proportional to the rate of hemoglobin degradation in HeLa cells.

1982 • 128 citations

Coordinated Induction of the Ubiquitin Conjugation Pathway Accompanies the Developmentally Programmed Death of Insect Skeletal Muscle

1995 • 124 citations

The prevention of cataract caused by oxidative stress in cultured rat lenses. I. H₂O₂and photochemically induced cataract

1993 • 114 citations

Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization

1995 • 114 citations

Ubiquitin and the Enigma of Intracellular Protein Degradation

1995 • 111 citations

Age-related Decline in Ubiquitin Conjugation in Response to Oxidative Stress in the Lens

1997 • 97 citations

The eye lens has an active ubiquitin-protein conjugation system.

1986 • 94 citations

Ubiquitin and the Enigma of Intracellular Protein Degradation

1995 • 89 citations

Ubiquitinylation and Ubiquitin-dependent Proteolysis in Vertebrate Photoreceptors (Rod Outer Segments)

1996 • 83 citations

Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae)

1994 • 81 citations

Delay of uv-induced eye lens protein damage in guinea pigs by dietary ascorbate

1986 • 79 citations

The relative roles of the glutathione redox cycle and catalase in the detoxification of H2O2 by cultured rabbit lens epithelial cells

1990 • 74 citations

Oxidant-Induced Activation of Protein Kinase C in Uc11mg Cells

1995 • 74 citations

Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs

1994 • 73 citations

The Ubc3 (Cdc34) ubiquitin-conjugating enzyme is ubiquitinated and phosphorylated in vivo.

1994 • 73 citations

Oxidation and Aging: Impact on Vision

1993 • 67 citations

The Superoxide Dismutase Mimic TEMPOL Protects Cultured Rabbit Lens Epithelial Cells from Hydrogen Peroxide Insult

1993 • 64 citations

Aging and cellular maturation cause changes in ubiquitin-eye lens protein conjugates

1990 • 64 citations

Ubiquitin and ubiquitin conjugates in human lens

1992 • 62 citations

Radio-isotopic determination of hydrogen peroxide in aqueous humor and urine

1991 • 62 citations

The Ubiquitin-activating Enzyme E1 Is Phosphorylated and Localized to the Nucleus in a Cell Cycle-dependent Manner

1996 • 52 citations

Degradation of differentially oxidized α-crystallins in bovine lens epithelial cells

1995 • 51 citations

Repair of H2O2-induced DNA damage in bovine lens epithelial cell cultures

1989 • 49 citations

Measures of leucine aminopeptidase can be used to anticipate UV-induced age-related damage to lens proteins: Ascorbate can delay this damage

1987 • 48 citations

The Photoreceptor G-Protein Transducin (Gt) Is a Substrate for Ubiquitin-Dependent Proteolysis

1994 • 45 citations

Ubiquitin in homeostasis, development and disease

1995 • 44 citations

Uncoupling ubiquitin-protein conjugation from ubiquitin-dependent proteolysis by use of .beta.,.gamma.-nonhydrolyzable ATP analogs

1991 • 43 citations

Protein ubiquitination is regulated by phosphorylation. An in vitro study.

1992 • 41 citations

Bovine lens epithelial cells have a ubiquitin-dependent proteolysis system

1993 • 41 citations

Dipeptide inhibitors of uniquitin-mediated protein turnover prevent growth factor-induced neurite outgrowth in rat pheochromocytoma PC12 cells

1992 • 37 citations

Oxidant-sensitive protein phosphorylation in endothelial cells

1994 • 33 citations

Regulation of protein kinase enzymatic activity in Jurkat T cells during oxidative stress uncoupled from protein tyrosine kinases: role of oxidative changes in protein kinase activation requirements and generation of second messengers.

1994 • 28 citations

Ubiquitin-activating enzyme, e1, is phosphorylated in mammalian cells by the protein kinase cdc2

1995 • 16 citations

Hydrogen peroxide in the eye lens: radioisotopic determination

1991 • 15 citations

Phosphorylation of ubiquitin-activating enzyme in cultured cells.

1995 • 14 citations

H₂O₂Determination in Rat Lens: Chemiluminescent versus Radioisotopic Methods

1995 • 8 citations