Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Cyclin is a component of maturation-promoting factor from Xenopus

1990 • 674 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.

1988 • 640 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

1990 • 444 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C

1990 • 425 citations

Induction of nuclear envelope breakdown, chromosome condensation, and spindle formation in cell-free extracts.

1985 • 407 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

Driving the cell cycle: M phase kinase, its partners, and substrates

1990 • 404 citations

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1991 • 369 citations

The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis

1987 • 334 citations

Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+

1988 • 314 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

SPXX, a frequent sequence motif in gene regulatory proteins

1989 • 276 citations

Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.

1988 • 257 citations

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.

1988 • 240 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

Xenopus oocytes and the biochemistry of cell division

1990 • 182 citations

Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.

1988 • 174 citations

Purification and characterization of a maturation-activated myelin basic protein kinase from sea star oocytes.

1990 • 141 citations

Phosphorylation changes associated with the early cell cycle in Xenopus eggs

1987 • 118 citations

Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization

1988 • 110 citations

In vivo Phosphorylation and Activation of Ribosomal Protein S6 Kinases during Xenopus Oocyte Maturation

1989 • 102 citations

Okadaic acid activates microtubule‐associated protein kinase in quiescent fibroblastic cells

1990 • 96 citations

Characterization of a mitogen‐activated, Ca²⁺‐sensitive microtubule‐associated protein‐2 kinase

1989 • 70 citations

Tyrosine Phosphorylation and Activation of Homologous Protein Kinases during Oocyte Maturation and Mitogenic Activation of Fibroblasts

1991 • 61 citations

Tyrosine phosphorylation by the epidermal growth factor receptor kinase induces functional alterations in microtubule-associated protein 2.

1987 • 57 citations