Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

1977 • 844 citations

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

1975 • 758 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 467 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3',5'-monophosphate dependent protein kinases

1977 • 264 citations

Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.

1988 • 256 citations

The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.

1987 • 241 citations

The minimum substrate of cyclic AMP-stimulated protein kinase, as studied by synthetic peptides representing the phosphorylatable site of pyruvate kinase (type L) of rat liver

1976 • 214 citations

Action of Adenosine 3',5'-Monophosphate-dependent Histone Kinase in Vivo

1969 • 203 citations

Structure of the Site Phosphorylated in the Phosphorylase b to a Reaction

1959 • 194 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

Further Studies on the Site Phosphorylated in the Phosphorylase b to a Reaction^*

1964 • 172 citations

Intrasteric regulation of protein kinases and phosphatases

1991 • 151 citations

Effect of denaturation on the susceptibility of proteins to enzymic phosphorylation

1975 • 135 citations

Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit.

1992 • 122 citations

Protein Kinase Inhibitor-(6-22)-amide Peptide Analogs with Standard and Nonstandard Amino Acid Substitutions for Phenylalanine 10

1989 • 114 citations

Synthetic substrate for cyclic AMP-dependent protein kinase

1975 • 96 citations

Identification of electrostatic interactions that determine the phosphorylation site specificity of the cAMP-dependent protein kinase

1991 • 75 citations

Studies on the specificity of phosphorylase kinase using peptide substrates.

1977 • 73 citations

Mutagenesis of the regulatory domain of rat protein kinase C-eta. A molecular basis for restricted histone kinase activity.

1993 • 61 citations

A Mutation in the Catalytic Subunit of cAMP-Dependent Protein Kinase That Disrupts Regulation

1988 • 59 citations

Bovine brain adenosine 3',5'-monophosphate dependent protein kinase. Mechanism of regulatory subunit inhibition of the catalytic subunit

1975 • 55 citations

Protein kinase domain of twitchin has protein kinase activity and an autoinhibitory region.

1994 • 49 citations

Peptides from myelin basic protein as substrates for adenosine 3′, 5′-cyclic monophosphate-dependent protein kinases

1974 • 44 citations

cAMP-dependent protein kinase defines a family of enzymes

1993 • 40 citations

High affinity binding of the heat-stable protein kinase inhibitor to the catalytic subunit of cAMP-dependent protein kinase is selectively abolished by mutation of Arg133.

1994 • 35 citations

Altered substrate selectivity of PKC‐η pseudosubstrate site mutants

1993 • 26 citations

Comparison of conservation within and between the Ser/Thr and Tyr protein kinase family: proposed model for the catalytic domain of the epidermal growth factor receptor

1994 • 9 citations