Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

1996 • 396 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14.

1993 • 177 citations

Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors

1993 • 146 citations

2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis

1995 • 131 citations

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

1993 • 123 citations

Tumor necrosis factors — the molecules and their emerging role in medicine

1992 • 121 citations

1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency

1996 • 119 citations

Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha.

1995 • 100 citations

Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles.

1994 • 76 citations

Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002

1988 • 71 citations

Molecular cloning of human p38 MAP kinase

1995 • 69 citations

Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles. Isomeric 4-pyridyl and 4-substituted-phenyl derivatives

1984 • 65 citations

Role of eosinophil-chemotactic C-C chemokines in cutaneous inflammation

1996 • 62 citations

Human Mitogen-activated Protein Kinase CSBP1, but Not CSBP2, Complements a hog1 Deletion in Yeast

1995 • 49 citations

Translational Control Mediated by UA-Rich Sequences

1990 • 42 citations

Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues

1990 • 39 citations

Synthetic and mechanistic studies on the preparation of pyridyl-substituted imidazothiazoles

1988 • 31 citations

Synthesis and reactions of cyclic amidines

1968 • 16 citations